Supervisor, Manufacturing Operations (Second Shift)

MFS Investments; Boston (MA); Hybride; USD 90 000 - 120 000; Plein temps

Avantages offerts par ce poste

Annual bonus

Equity awards

Commuting subsidy

Paid time off

Résumé du poste

Vertex Pharmaceuticals in Boston, MA is seeking a Manufacturing Operations Supervisor for the second shift to lead a small team in GMP cell processing, ensuring quality and compliance across adherent and suspension cultures.

You will hire, train, coach, and schedule 2–8 direct reports, liaise with cross-functional partners on quality systems, CAPAs, SOPs, and batch records, and troubleshoot equipment alarms in a cleanroom setting. On-site five days per week.

Qualifications

• Extensive GMP experience with lead or trainer responsibilities.
• Minimum 3 years cell culture experience in adherent and suspension cultures.
• Direct supervisory experience is required.
• Working knowledge of GMP manufacturing (21 CFR 210/211) and quality systems (21 CFR 820).
• Experience with bioreactors and cell processing for clinical materials.

Responsabilités

• Lead a team of 2–8 direct reports; hire, train, and coach to achieve cGMP standards.
• Ensure cGMP compliance through education and oversight of the team.
• Schedule personnel in coordination with Manufacturing leadership.
• Manage projects, timelines, and lead cross-functional meetings.
• Investigate quality events, CAPAs, deviations, change controls, and risk assessments.
• Create and update SOPs and Batch Records; manage equipment alarms.
• Serve as SME; troubleshoot issues in a cleanroom environment.

Connaissances

GMP experience

Cell culture

Supervisory experience

SOPs & batch records

Scheduling & leadership

Quality systems

Problem solving

Cross-functional collaboration

Formation

Bachelor's degree in life sciences

Minimum 3 years cell culture experience

Outils

Microsoft Word

Microsoft Excel

Microsoft Project

Outlook

eQMS / electronic quality systems

Description du poste

# Supervisor, Manufacturing Operations (Second Shift)Vertex PharmaceuticalsBoston, MAFull-TimeSep 29, 2026Pharmaceutical## Job Description**Job Description****Job Description**The Manufacturing Operations Supervisor is a critical first-line leadership role within Cell Manufacturing. This position is responsible for direct management of personnel executing GMP cell processing operations for adherent and suspension cell cultures. The candidate will have strong leadership skills, GMP expertise, and commitment to patients.**The Supervisor will work one of the following shifts:**Second Shift - Tuesday to Saturday, 2:30PM - 11PMSecond Shift - Sunday to Thursday, 2:30PM - 11PM**Key Duties and Responsibilities:*** Builds and develops an efficient team of 2-8 direct reports capable of consistently producing clinical cellular product or intermediates according to cGMP standards. Includes hiring, orienting, training and coaching of personnel.* Ensures cGMP compliance through direct oversight and education of team members.* Shares responsibility of scheduling of personnel in coordination with other Manufacturing leadership.* Manages direct reports’ projects to achieve department and corporate goals, including managing timelines and leading group meetings.* Leads, investigates, and collaborates with cross-functional stakeholders regarding quality systems, including quality events, deviations, CAPAs, change controls, and risk assessments.* Creates, revises, and reviews controlled documents including Standard Operating Procedures (SOPs) and Batch Records for manufacturing.* Receive and manage equipment alarms.* Serves as a technical SME for the team, troubleshoots problems independently.* Demonstrates the Vertex Phenotype behaviors: Lead by Example; Learn, Teach & Develop; Foster Exceptional Collaboration; Drive Breakthrough Results; and Promote Enterprise Thinking* Other duties and projects as assign as required to meet departmental requirements.**Knowledge and Skills:*** Extensive GMP experience, including as a lead or trainer* Minimum of 3 years of cell culture experience, ideally in both adherent and suspension cultures* A minimum of 0-2 years direct supervisory experience* Working knowledge of federal requirements for GMP manufacturing (21CFR 210,211) and Quality Systems (21CFR 820)* Expertise in cell processing and culture technologies for clinical materials production required* Experience with bioreactors for cell culture* Excellent computer skills including Word, Excel, Project, Outlook, equipment interfaces and electronic quality systems**Environment:*** Works in a cleanroom and office setting* Must be able to remain in a stationary position 50% during processing activities* Frequently move about inside the cleanroom to accomplish process tasks* Occasionally moves lab equipment and materials weighing up to 50 pounds. At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.**Pay Range:**$0 - $0**Disclosure Statement:**The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.**Flex Designation:**On-Site Designated**Flex Eligibility Status:**In this **On-Site** designated role, you will work **five days per week on-site** with ad hoc flexibility.Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.#LI-Onsite