Strategic Leader: Peptide API Development & CMC

Neurocrine Biosciences; San Diego (CA); On-site; USD 174,000 - 237,000; Full time

Benefits offered by this job

Annual bonus

Equity incentive

Comprehensive benefits

Fortune Best Workplace

Job summary

Neurocrine Biosciences is seeking a senior leader to head peptide chemistry and peptide API development from early development through commercialization. You will define scientific strategy, oversee cross-functional teams, and translate regulatory expectations into practical development plans across the peptide portfolio.

The role requires deep expertise in peptide synthesis (SPPS/LPPS), process development, scale-up, and manufacturing readiness, with strong leadership and collaboration across

Qualifications

• BS/BA in chemistry, biochemistry, biology, chemical engineering, or similar field with 10+ years of relevant experience; or MS/MA with 8+ years; or PhD with 6+ years.
• Substantial hands-on and/or technical leadership in peptide synthesis, process development, scale-up, tech transfer, or GMP peptide manufacturing.
• Industry experience in peptide API process development and/or manufacturing is strongly preferred.

Responsibilities

• Apply advanced peptide and organic chemistry to cross-asset API development challenges.
• Lead teams across multiple development programs in peptide chemistry and process development.
• Define strategy, governance, and technical decision standards for peptide API development.
• Develop and optimize peptide manufacturing: SPPS/LPPS, cleavage, purification, and isolation.
• Drive scale-up, tech transfer, and manufacturing readiness from lab to commercial scale.
• Identify CQAs, CMAs, CPPs, and in-process controls; design robust control strategies.
• Oversee GMP manufacturing and external site activities; ensure safety and efficiency.

Skills

Peptide synthesis

SPPS

LPPS

Process development

Technical leadership

GMP knowledge

cGMP understanding

Regulatory knowledge

Cross-functional work

Mentoring

Education

BS/BA in chemistry/biochemistry/biology/chemical engineering

MS/MA in chemistry/biochemistry/biology/chemical engineering

PhD in chemistry/peptide chemistry/biochemistry/chemical engineering

Tools

Bioconjugation knowledge

Fragment condensation

Job description

Neurocrine Biosciences is seeking a senior leader to head peptide chemistry and peptide API development from early development through commercialization. You will define scientific strategy, oversee cross-functional teams, and translate regulatory expectations into practical development plans across the peptide portfolio.

The role requires deep expertise in peptide synthesis (SPPS/LPPS), process development, scale-up, and manufacturing readiness, with strong leadership and collaboration across