Strategic Director, Statistical Programming

Alnylam Pharmaceuticals, Inc.; United States; On-site; USD 181,100 - 244,900; Full time

Benefits offered by this job

Medical benefits

Dental benefits

Vision benefits

401(k) with company match

Paid time off

Job summary

Alnylam Pharmaceuticals, Inc. is seeking an Associate Director of Statistical Programming to lead the delivery of high-quality SAS and R programming for clinical studies and NDA submissions.

You will oversee teams, partner with Biostatistics and Data Management, and drive standardization across CDISC ADaM/SDTM workflows. The role requires extensive SAS expertise, strong leadership, and experience with vendor management.

Qualifications

• At least 10 years of SAS programming experience in pharma/CRO.
• Experience as a Programming manager (FTEs, vendors or FSOs).
• Experience leading programming teams in clinical trials to report results or support NDA/BLA submissions.
• Experience building technical programming specifications and validated SAS programs.
• Proficiency with CDISC standards including SDTM, ADaM, and Define.XML.
• Hands-on SAS knowledge (Base, Macro, STAT, Graph, SQL).
• Hands-on experience with R for trial data analysis, reporting, and regulatory submissions.
• Knowledge of Posit Workbench, RStudio Server, Posit Package Manager, and enterprise R environments.
• Experience developing SOPs and programming standards; vendor oversight.

Responsibilities

• Provides technical and operational leadership in delivering high-quality programming for clinical studies and NDA submissions.
• Collaborates with Biostatistics to implement analyses and validate CDISC ADaM datasets and TLFs.
• Helps define CDISC SDTM/ADaM specifications and datasets and supports data management and pharmacology teams.
• Manages internal and vendor programming support with governance for external partners.
• Writes SAS and R code to produce or validate tables, listings, figures, and analysis datasets.
• Coordinates multi-project timelines to ensure timely, quality delivery across programs.

Skills

SAS programming

R programming

CDISC SDTM/ADaM

Define XML

SAS/STAT

SAS/Base/Macro

Leadership

Communication

Vendor management

Education

Bachelor’s in computer science / statistics / mathematics / information sciences

Tools

Posit Workbench

RStudio Server

Posit Package Manager

Enterprise R environments

Job description

Alnylam Pharmaceuticals, Inc. is seeking an Associate Director of Statistical Programming to lead the delivery of high-quality SAS and R programming for clinical studies and NDA submissions.

You will oversee teams, partner with Biostatistics and Data Management, and drive standardization across CDISC ADaM/SDTM workflows. The role requires extensive SAS expertise, strong leadership, and experience with vendor management.