Senior Statistical Programming Leader (SAS & R)

Alnylam Pharmaceuticals; Cambridge (MA); On-site; USD 181,100 - 244,900; Full time

Benefits offered by this job

Medical benefits

401(k) match

Paid time off

Wellness days

Recharge breaks

Job summary

Alnylam Pharmaceuticals seeks an Associate Director, Statistical Programming to lead programming activities for clinical trials and NDA submissions. You will ensure SAS programs are developed, validated, and aligned with ICH and regulatory requirements.

Role requires SAS expertise, CDISC ADaM/SDTM experience, and leadership of programming teams with collaboration across statistics, data management, and CRO vendors.

Qualifications

• Bachelor's degree in computer science, statistics, mathematics or information sciences required.
• Master's degree preferred in a related field.
• Minimum 10 years of industry SAS programming experience or equivalent.
• Experience leading programming teams for clinical trials and NDA/BLA submissions.
• Strong knowledge of CDISC standards: SDTM and ADaM.

Responsibilities

• Provide technical and/or operational leadership in delivering high-quality programming for clinical studies and NDA submissions.
• Collaborate with Biostatistics to implement analyses and develop CDISC specifications/datasets and TLFs.
• Coordinate with Data Management on CDISC SDTM/ADaM development and validation.
• Manage internal and vendor statistical programming support and governance.
• Write SAS and R code to produce/validate tables, listings, figures, and analysis datasets.

Skills

SAS programming

CDISC SDTM/ADaM

SAS/SQL

R programming

Team leadership

Statistical programming environments

Education

Bachelor's degree in CS/Stats/Math/Info Sci

Master's degree preferred

Tools

SAS

R

Posit Workbench

Job description

Alnylam Pharmaceuticals seeks an Associate Director, Statistical Programming to lead programming activities for clinical trials and NDA submissions. You will ensure SAS programs are developed, validated, and aligned with ICH and regulatory requirements.

Role requires SAS expertise, CDISC ADaM/SDTM experience, and leadership of programming teams with collaboration across statistics, data management, and CRO vendors.