Strategic AI Projects Lead

AfterQuery; San Francisco (CA); Hybrid; USD 180,000 - 260,000; Full time

Job summary

AfterQuery is an applied research lab building data solutions for foundation model development. You will join a fast-growing team in San Francisco to lead data-driven projects spanning healthcare, finance, software, and law, shaping dataset specifications and end‑to‑end delivery for frontier models.

You will manage expert teams across domains, collaborate with top AI organizations, and own critical initiatives from scoping to delivery while gaining top-tier operational experience in a dynamic,

Qualifications

• 3+ years of experience in healthcare, medical research, health technology, a top-tier biopharma company, or another highly selective healthcare / medicine environment (having an MD is a plus)
• Background in medicine, clinical practice, biomedical research, healthcare operations, or another relevant discipline
• Strong understanding of healthcare data, systems, clinical workflows, medical research, or the healthcare industry
• High agency, drive, and a strong work ethic; thrive in ambiguity and execute with minimal direction
• Passion for healthcare, AI, and entrepreneurship, with an interest in using emerging technology to improve how medical knowledge is developed, evaluated, and applied
• Competitive nature and a demonstrated record of exceptional achievement
• Strong leadership experience and excellent written and verbal communication skills
• Thrive in fast-moving, high-impact environments with bias towards action, while balancing attention to detail
• Comfort working with data, technical systems, and AI tools

Responsibilities

• Project and client management: Work with the world’s leading AI organizations to build next-generation data solutions that push the limits of model capability, while directly driving revenue.
• Manage expert teams across domains: Lead and coordinate highly specialized contributors across fields like healthcare, medicine, and biopharma.
• Shape how AI systems are trained: Design dataset specifications that directly influence how frontier models are evaluated and improved.
• Drive high-impact execution end-to-end: Own critical projects from idea to delivery. From scoping, executing, iterating, and shipping in a fast-moving, high-stakes environment, you will touch it all.
• Gain top tier operational experience: Support the team across a range of operational initiatives that will directly contribute to the future of AfterQuery.

Skills

Healthcare knowledge

Leadership experience

Communication skills

Data & AI tools

Education

MD preferred

Tools

Python

Claude Code

Job description

About AfterQuery

AfterQuery is an applied research lab curating data solutions for foundation model development. We serve every frontier AI lab with the mission of delivering the best data to power the best models. In doing so, we can make expertise that once took a lifetime to build available to anyone who needs it.

Our customers are the ones building the foundation models themselves and our work sits directly in the loop of how those systems improve. This is a rare opportunity to join a company at a defining moment in AI. Forbes reported that we could be YC's fastest unicorn, reportedly raising at a $3.2 billion valuation. We're based in San Francisco and backed by leading investors including Altos Ventures, BoxGroup, and Y Combinator and angels from Google DeepMind, OpenAI, Anthropic, Meta Superintelligence Labs, and Microsoft AI.

Why Apply

Massive Opportunity: Forbes reported that we could be YC's fastest unicorn, reportedly raising at a $3.2 billion valuation, and we're not slowing down.

Founding Impact: You will own and architect core infrastructure systems that power our platform from the ground up.

Equity & Growth: Competitive salary and meaningful equity. As we scale, you’ll have the opportunity to shape the engineering organization and lead major technical initiatives.

Strong Team: Our founding team has experience from Citadel Securities, Meta, Google, Silver Lake, and Morgan Stanley — work alongside world-class engineers and researchers.

Overview

You'll work directly with the world's leading AI organizations to build next-generation data solutions, managing expert teams across domains like finance, software engineering, and law to produce high-quality outputs at scale. You'll shape dataset specifications that directly influence how frontier models are evaluated and improved, owning critical projects end-to-end from scoping through delivery in a fast-moving, high-stakes environment. Along the way, you'll gain top-tier operational experience, working across multiple parts of the business — building, analyzing, coordinating, and executing wherever it's needed most.

Responsibilities

• Project and client management: Work with the world’s leading AI organizations to build next-generation data solutions that push the limits of model capability, while directly driving revenue.

• Manage expert teams across domains: Lead and coordinate highly specialized contributors across fields like healthcare, medicine, and biopharma.

• Shape how AI systems are trained: Design dataset specifications that directly influence how frontier models are evaluated and improved. Your taste and judgement will shape what foundation models become.

• Drive high-impact execution end-to-end: Own critical projects from idea to delivery. From scoping, executing, iterating, and shipping in a fast-moving, high-stakes environment, you will touch it all.

• Gain top tier operational experience: Support the team across a range of operational initiatives that will directly contribute to the future of AfterQuery. You will work across multiple parts of the business in the same week, ranging from building, analyzing, coordinating, and executing where needed most.

Required Qualifications

• 3+ years of experience in healthcare, medical research, health technology, a top-tier biopharma company, or another highly selective healthcare / medicine environment (having an MD is a plus)

• Background in medicine, clinical practice, biomedical research, healthcare operations, or another relevant discipline

• Strong understanding of healthcare data, systems, clinical workflows, medical research, or the healthcare industry

• High agency, drive, and a strong work ethic; thrive in ambiguity and execute with minimal direction

• Passion for healthcare, AI, and entrepreneurship, with an interest in using emerging technology to improve how medical knowledge is developed, evaluated, and applied

• Competitive nature and a demonstrated record of exceptional achievement

• Strong leadership experience and excellent written and verbal communication skills

• Thrive in fast-moving, high-impact environments with bias towards action, while balancing attention to detail

• Comfort working with data, technical systems, and AI tools

Preferred Qualifications

• Proficiency in Python; experience coding, scripting, analyzing healthcare data, conducting clinical research, or using AI tools to automate workflows and build products.

• Enjoy experimenting with new tools (experience with Claude Code is a plus)

Company Benefits (For Eligible Employees):

• Health Insurance: Medical, Vision, Dental

• 401(k) with Employer Match

• Daily Meals: Daily UberEats Stipend

• Monthly Wellness Stipend

We are an equal opportunity employer committed to providing a workplace free from discrimination and harassment. Employment decisions are made without regard to legally protected characteristics under applicable federal, state, or local law.

We comply with applicable pay transparency requirements and provide compensation ranges based on the position, qualifications, experience, and other relevant factors. Reasonable accommodations are available to qualified individuals with disabilities and for sincerely held religious beliefs, as required by law. This job description is intended to describe the general nature and level of work performed and is not an exhaustive list of all duties, responsibilities, qualifications, or working conditions associated with the position. We reserve the right to modify this job description as business needs change.