Staff Software Engineer, Variant Classification

Labcorp; San Francisco (CA); Hybrid; USD 100,000 - 198,000; Full time

Benefits offered by this job

Annual bonus

401(k) plan

Medical, Dental, Vision coverage

Paid Time Off (PTO) or Flexible Time

Job summary

Labcorp Genetics is seeking a Staff Software Engineer, Variant Classification to join our genetics team. This full-time role focuses on constructing tools for conveying variant, sample, and test level data to support accurate interpretation and reporting.

You will translate raw bioinformatic data into structured information, scale data storage, and automate evidence placement while collaborating with data scientists and software engineers to meet stakeholder needs.

Qualifications

• Bachelor’s degree with 10+ years of professional software development experience.
• 10+ years of Python development experience (intermediate or higher).
• 10+ years of experience with relational databases and web development frameworks.
• 10+ years of experience with front-end technologies (React/Angular/Vue.js/JS/TS/HTML/CSS).
• 10+ years of experience with RESTful APIs and microservices architecture.
• 10+ years of experience with CI/CD pipelines and DevOps practices.
• 10+ years of experience with cloud platforms (AWS, Azure, or GCP).

Responsibilities

• Design and build tools to store and provide variant, sample, and test level information for interpretation and report generation.
• Translate raw bioinformatic data into variant and sample level information with registration, normalization, and quality metrics.
• Scale and optimize storage of sample level information for growth.
• Provide annotations at the variant level for accurate interpretation.
• Automate evidence placement and classification for variant interpretation.
• Support test content and assay development initiatives.
• Collaborate with data scientists, variant scientists, and software developers to meet requirements.

Skills

Python

Relational databases

Front-end frameworks

RESTful APIs

CI/CD

Cloud platforms

Education

Bachelor's degree

Master’s or Ph.D. in Bioinformatics/Computational Biology

Job description

Labcorp is a global leader in laboratory services, providing the insights and answers that help healthcare providers, patients, researchers, pharmaceutical companies and health systems make confident decisions and improve outcomes. Through our unparalleled science, data, technology and laboratory network, we advance diagnostics, accelerate innovation and help address some of the world’s most important health challenges. As we shape the future of healthcare, we are leveraging advanced technologies, intelligent digital solutions and data-driven innovation across our operations to enhance how work gets done and deliver greater value to customers and patients. With our global scale and deep expertise, you’ll have the opportunity to do meaningful work, grow your career and make a real impact on people’s health around the world. Together, we’re improving health and improving lives.

Labcorp is seeking a Staff Software Engineer, Variant Classification to join our Labcorp Genetics team.

Work Schedule

This is a full‑time, exempt (salaried) position assigned to a First Shift schedule, with standard business hours of Monday through Friday, 8:00 a.m. to 5:00 p.m. in your local time zone. Business needs may occasionally require flexibility in work hours, including earlier, later, or additional hours, with reasonable notice provided when possible.

Applicants who live within 35 miles of either the Burlington, NC or Durham, NC location will follow a hybrid schedule. This schedule includes a minimum of three in‑office days per week at an assigned location, either Burlington or Durham, supporting both collaboration and flexibility.

Job Responsibilities

• Design and build tools that define, store, and provide meaningful variant, sample, and test level information to support accurate variant interpretation and report generation
• Develop and maintain systems that translate raw bioinformatic data into variant and sample level information, including registration, normalization, observation groups, and quality metrics
• Scale and optimize storage of sample level information to support growing data needs
• Source, maintain, and provide annotations at the variant level necessary for accurate variant interpretation
• Automate evidence placement and classification for variant interpretation
• Support test content and assay development initiatives
• Collaborate with data scientists, variant scientists, and software developers to design and implement solutions that meet stakeholder requirements

Minimum Qualifications

• Bachelor’s degree with 10 or more years of recent professional software development experience
• 10 or more years of experience with Python (intermediate level or higher)
• 10 or more years of experience with relational databases and web development frameworks
• 10 or more years of experience with front‑end technologies (e.g., React, Angular, Vue.js, JavaScript/TypeScript, HTML/CSS)
• 10 or more years of experience with RESTful APIs and microservices architecture
• 10 or more years of experience with CI/CD pipelines and DevOps practices
• 10 or more years of experience with cloud platforms (AWS, Azure, or GCP)

Preferred Qualifications

• Master’s Degree or Ph.D. in Bioinformatics/Computational Biology or life sciences
• 8 or more years of experience mentoring and developing senior and junior engineers across multiple teams
• 8 or more years of experience defining technical vision and driving multi‑year roadmaps
• 3 or more years of experience with bioinformatic tools and annotation
• 3 or more years of experience with variant databases and genomic data resources (e.g., ClinVar, gnomAD, HGMD)
• 3 or more years of experience in Spark, text mining, natural language processing, semantic enrichment, ontologies, data mining, or machine learning/AI
• 3 or more years of experience with public‑domain biomedical terminologies (e.g., MeSH, NCIt, HGNC)
• 3 or more years of experience translating complex scientific questions into information solutions
• Current or prior Labcorp experience

Additional Job Standards

• Owns and delivers product or platform goals across multiple years and teams, setting a high standard for technical outcomes and delivery
• Defines the vision, scope, and technical approach for large, business‑impacting projects with organization‑wide implications
• Identifies, prioritizes, and drives solutions to ambiguous, open‑ended problems across multiple teams
• Influences the roadmaps of partner teams to align with and achieve broader business goals
• Serves as a role model and technical authority for engineers across multiple teams
• Effective verbal and written communicator with both scientific and non‑scientific audiences
• Effective with GitHub Copilot, Claude Code or similar LLM tools to accelerate coding, testing and documentation

About Labcorp Genetics

Labcorp Genetics (formerly Invitae) is dedicated to bringing comprehensive genetic information into mainstream medicine to improve healthcare for billions of people. The Variant Classification team builds and maintains the tools that define, store, and provide meaningful and detailed variant, sample, and test level information to support accurate variant interpretation and report generation. Our services support interpretation reporting of genetic variants and assay development across a suite of critical platforms including SDS, VDB, Argus, iVEP, Evidence Service, MoonPy, Cerebro, Universal Transcript Archive, SeqRepo, and Assay CMS.

At Labcorp we have a passion for helping people live happy and healthy lives. Every day we provide vital information that helps our clients and patients understand their health. If you are passionate about helping people and have a drive for service, then Labcorp could be a great next career step!

Application Window: 8/29/2026

Pay Range: $100K - $198K/yr

LBP Only: The position is also eligible for an annual bonus under the Labcorp Bonus Plan. Bonuses are payable based on corporate and/or business segment performance and are subject to individual performance modifiers.

Benefits: Employees regularly scheduled to work 20 or more hours per week are eligible for comprehensive benefits including: Medical, Dental, Vision, Life, STD/LTD, 401(k), Paid Time Off (PTO) or Flexible Time Off (FTO), Tuition Reimbursement and Employee Stock Purchase Plan. Employees regularly scheduled to work less than 20 hours, Casual, Intern, and Temporary employees are only eligible to participate in the 401(k) Plan. Employees who are regularly scheduled to work a 7 on/7 off schedule are eligible to receive all the foregoing benefits except PTO or FTO. For more detailed information, pleaseclick here.

Labcorp Is Proud To Be An Equal Opportunity Employer

Labcorp strives for inclusion and belonging in the workforce and does not tolerate harassment or discrimination of any kind. We make employment decisions based on the needs of our business and the qualifications and merit of the individual. Qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex (including pregnancy, childbirth, or related medical conditions), family or parental status, marital, civil union or domestic partnership status, sexual orientation, gender identity, gender expression, personal appearance, age, veteran status, disability, genetic information, or any other legally protected characteristic. Additionally, all qualified applicants with arrest or conviction records will be considered for employment in accordance with applicable law.

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