Staff Scientist - Hematologic Malignancies and Cancer Immunotherapy

aa067; Monrovia (CA); On-site; USD 90,000 - 130,000; Full time

Job summary

City of Hope in California seeks a Staff Scientist to join the Zhang and Marcucci Laboratories in hematologic malignancies and cancer immunotherapy.

The role emphasizes cell culture, flow cytometry, in vivo mouse studies, data analysis, and manuscript and grant preparation, with a focus on CAR T‑cell therapy, leukemia stem cells, microenvironment, and microRNA biology.

You will lead independent and collaborative projects and contribute to translational research and high‑impact publications.

Qualifications

• Ph.D. in Immunology, Cancer Biology, Hematology, Molecular Biology, or related field.
• Hands-on experience with cell culture, flow cytometry, molecular biology, and mouse studies.
• Excellent communication, organizational, and scientific writing skills.

Responsibilities

• Perform cell culture, lentiviral transduction, and molecular biology experiments.
• Conduct multi-color flow cytometry and data analysis.
• Perform in vivo studies using mouse models, including various administration routes.
• Analyze data, prepare manuscripts and grant applications, and present findings.

Skills

Cell culture

Flow cytometry

Molecular biology techniques

In vivo mouse studies

Education

PhD in Immunology, Cancer Biology, Hematology, Molecular Biology

Tools

CRISPR/Cas9

qPCR

Western blotting

Job description

Join the forefront of groundbreaking research at City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research.

The Zhang and Marcucci Laboratories at City of Hope are seeking a highly motivated Staff Scientist to join our research program in hematologic malignancies and cancer immunotherapy. Our research focuses on leukemia stem cells, the tumor microenvironment, CAR T-cell therapy, bispecific T-cell engagers, and microRNA biology, with the goal of developing novel therapies for leukemia and myeloproliferative neoplasms.

The successful candidate will lead independent and collaborative projects and contribute to high-impact publications and translational research.

As a successful candidate, you will:

• Perform cell culture, lentiviral transduction, and molecular biology experiments.

• Conduct multi-color flow cytometry and data analysis.

• Perform in vivo studies using mouse models, including oral gavage, intravenous, and intraperitoneal injections.

• Analyze data, prepare manuscripts and grant applications, and present research findings.

Your qualifications should include:

• Ph.D. in Immunology, Cancer Biology, Hematology, Molecular Biology, or a related field.

• Hands-on experience with cell culture, lentiviral transduction, flow cytometry, molecular biology (e.g., CRISPR/Cas9, qPCR, Western blotting), and mouse studies.

• Excellent communication, organizational, and scientific writing skills.

Preferred qualifications:

• Experience with CAR T-cell engineering, patient-derived xenograft (PDX) models, or cancer immunotherapy.

City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location.

City of Hope is an equal opportunity employer.