Staff Scientist - Hematologic Malignancies

City of Hope; California (MO); On-site; USD 54,000 - 182,000; Full time

Job summary

City of Hope, a leading research and treatment institution, seeks a Staff Scientist for translational studies in hematologic malignancies. The role involves in vivo modeling, flow cytometry, genomic and transcriptomic analyses, and collaboration with clinical teams to advance diagnostics and therapies.

You will design experiments, supervise lab operations, mentor junior staff, and maintain meticulous records while adhering to safety and regulatory standards.

Qualifications

• PhD, MD, or MD/PhD in a biomedical field with at least 3 years' hands-on experience in hematologic malignancies.
• Expertise in data analysis and immunophenotyping; cell sorting experience desirable.
• Experience designing experiments with mouse models, primary human samples, and genomic profiling tools (NGS, RNA-seq).
• Proven leadership in mentoring junior staff and managing laboratory operations.

Responsibilities

• Design and execute experiments with mouse models, patient samples, and molecular assays.
• Develop and optimize protocols for studying disease mechanisms and diagnostic refinement.
• Analyze data and collaborate with bioinformatics staff when necessary.
• Troubleshoot laboratory equipment and coordinate maintenance and QC.
• Work with team to design experiments, interpret findings, and contribute to manuscript and grant preparation.
• Communicate results to faculty, trainees, and clinical collaborators; participate in team meetings.
• Provide mentorship and training to junior lab members.
• Maintain meticulous records and ensure data reproducibility.
• Adhere to safety regulations for human samples and animal models.

Skills

Immunophenotyping

Mouse models

Data analysis

Mentoring / leadership

Study design

Project coordination

Communication

Laboratory safety

Education

PhD, MD, or MD/PhD in biomedical field

Tools

Flow cytometry

NGS

RNA-Seq

Cell sorting

Job description

Join the forefront of groundbreaking research at City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research.

A Staff Scientist position is available in the research laboratory of the Division of Hematopathology, Department of Pathology at City of Hope. A Staff Scientist focuses on translational research in hematologic malignancies using genetically engineered mouse models, patient-derived samples, and molecular profiling techniques. The Staff Scientist will lead and support experiments involving in vivo modeling, flow cytometry, genomic and transcriptomic analysis, and tissue-based assays to investigate disease mechanisms, identify biomarkers, and refine diagnostics. Responsibilities include experimental design, data interpretation, manuscript preparation, and supervision of lab operations, with collaboration across clinical and research teams to advance studies with direct diagnostic and therapeutic impact.

For more information about Dr. You’s lab, please visit here.

As a successful candidate, you will:

• Design and execute experiments involving genetically engineered mouse models, patient-derived samples, and molecular assays, including DNA/RNA sequencing, immunohistochemistry, and flow cytometry.

• Develop and optimize laboratory protocols for studying disease mechanisms, biomarker discovery, and diagnostic refinement in hematologic malignancies.

• Analyze and interpret experimental data using appropriate computational tools and collaborate with bioinformatics staff when necessary.

• Troubleshoot laboratory equipment (e.g., flow cytometers, sequencers) and coordinate routine maintenance and quality control.

• Work collaboratively with team members to design experiments, interpret findings, and contribute to manuscript and grant preparation.

• Communicate experimental results clearly to faculty, trainees, and clinical collaborators; contribute to team meetings and project planning.

• Provide mentorship and training to junior lab members on experimental design, execution, and data analysis.

• Maintain meticulous and organized records of all experiments and ensure proper documentation for data reproducibility.

• Adhere to institutional and laboratory safety regulations and compliance standards for working with human samples and animal models.

Your qualifications should include:

• PhD, MD, or MD/PhD degree in a relevant biomedical field (or commensurate experience) with a minimum of 3 years of hands-on experience in a clinical or research laboratory focused on hematologic malignancies, molecular pathology, or flow cytometry.

• Demonstrated expertise in data analysis and immunophenotyping; experience with cell sorting is highly desirable.

• Proven ability to design and execute experiments using mouse models, primary human samples, and genomic profiling tools (e.g., NGS, RNA-seq).

• Demonstrated leadership in mentoring junior staff and managing laboratory operations.

City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location.

City of Hope is an equal opportunity employer.

Salary / Pay Rate Information:
Pay Rate: $38.96 - $132.16 / hour

The estimated pay scale represents the typical [salary/hourly] range City of Hope reasonably expects to pay for this position, with offers determined based on several factors which may include, but not be limited to, the candidate’s experience, expertise, skills, education, job scope, training, internal equity, geography/market, etc. This pay scale is subject to change from time to time.