STAFF SCIENTIST

LSU Health Sciences Center New Orleans; New Orleans (LA); Hybrid; USD 70,000 - 110,000; Full time

Benefits offered by this job

Health insurance

Retirement plans

Paid holidays

Wellness benefits

Employee health clinic

Pet insurance option

Job summary

LSU Health Sciences Center New Orleans is seeking a Staff Scientist to study how obesity-driven changes influence prostate cancer metabolism and epigenetic remodeling. The role will lead multi-omic integration and CRISPR-based validation to identify targets for therapy.

The candidate will design high-throughput workflows and collaborate on manuscript preparation and extramural funding efforts, within the Center of excellence-Cancer at the Cancer Center site.

Qualifications

• PhD required in Basic Science, Health Science, Bioinformatics or related field.
• Experience in a research environment; substitution: MD or DDS acceptable.

Responsibilities

• Investigate how obesity-related changes affect prostate cancer metabolism and epigenetics.
• Lead projects on tumor microenvironment interactions and therapeutic resistance.
• Design and execute high-throughput multi-omic workflows (RNA-seq, ChIP-seq, ATAC-seq, metabolomics).
• Apply CRISPR-Cas9 screens and targeted editing to validate resistance drivers.
• Develop pipelines to interpret complex multi-omic data and support manuscripts and funding.

Skills

CRISPR-Cas9

Multi-omics

RNA-seq

ChIP-seq

ATAC-seq

Metabolomics

Computational analysis

Gene editing

Education

PhD

Related field (Biology/Bioinformatics)

Job description

Closing date: December 25, 2026

Title: STAFF SCIENTIST

Employee Type:Other Academic

Department: Center of excellence-Cancer

Campus Location:CANCER CENTER/SETON BLDG./2025

Job Summary/Basic Functions

The Staff Scientist Staff Scientist will investigate the critical intersection of host metabolic health and tumor biology. Specifically, they will study how obesity-induced systemic changes drive metabolic reprogramming and epigenetic remodeling in prostate cancer. Research will place special emphasis on how these dual mechanisms converge to promote therapeutic resistance and lineage plasticity, with the goal of identifying novel therapeutic targets.
The Staff Scientist will lead projects investigating how obesity alters the prostate tumor microenvironment, focusing on crosstalk among adipocyte-derived factors, tumor metabolism, and epigenetic states (e.g., histone modifications, DNA methylation). Uncover pathways that promote survival and lineage plasticity under therapeutic stress, including androgen deprivation therapy (ADT) and next-generation anti-androgens. They will be responsible for Multi-Omic Integration: Design and execute high-throughput multi-omic workflows that integrate data from RNA-seq, ChIP-seq, ATAC-seq, and metabolomics. The Staff Scientist will also apply CRISPR-Cas9 genetic screens and targeted gene editing to functionally validate candidates that drive drug resistance, conduct independent computational analyses and develop pipelines to interpret complex multi-omic data and, help with the preparation of high-impact manuscripts and actively pursue extramural funding.

Minimum Qualifications

Required Education:PhD

Required Field of Study:Basic Science, Health Science, Bioinformatics, or related field

Number of years required to perform the job:0 - 2 years

Type of experience required to perform the job:Experience in a research environment

Substitution:MD or DDS are also acceptable

Comprehensive benefits are available to eligible employees and their dependents

• health, life, dental, and vision insurance
• flexible spending accounts
• retirement plans
• generous annual and sick leave
• 14 paid holidays per year
• an employee health primary care clinic

Other employee benefits include

• full-service credit union
• wellness benefits featuring complementary fitness center membership for employees and their spouses
• employee assistance program
• campus assistance program
• pet insurance option

See following link for more details on our benefits offerings: LSUHSC, New Orleans - Benefits

More information about these benefits can be found on this webpage: Additional Benefits