Staff Scientist

Boston Children's Hospital; Boston (MA); On-site; USD 110,000 - 150,000; Full time

Benefits offered by this job

Flexible schedules

Affordable health

Vision and dental insurance

Child care subsidies

Student loan subsidies

Time off

403(b) Retirement Savings plan

Pension

License and Certification Reimb.

Cell phone discounts

T-passes discounts

Job summary

Boston Children’s Hospital is seeking a Staff Scientist to work in the Human Neuron Core on iPSC-derived neurons to model neurological disease. You will differentiate iPSCs, phenotype neurons, and learn novel techniques like high-content imaging, MEA recording, and genome editing in a fast-paced, collaborative environment.

The role emphasizes independent research, mentorship of junior staff, and contribution to publications, within a Harvard-network setting renowned for neuroscience and stem

Qualifications

• Master's degree in a STEM field with 7+ years of research experience.
• Experience differentiating iPSCs into neurons and glia.
• Strong experimental expertise in iPSC culture and neuroscience.

Responsibilities

• Differentiating iPSCs into neuronal and glial subtypes.
• Phenotyping neurons using various technologies.
• Developing high-content imaging and MEA analysis pipelines.
• Mentoring Research Assistants and presenting results.
• Preparing manuscripts for publication.

Skills

iPSC culture

neuroscience

high-content imaging

MEA analysis

genome editing

data analysis

Education

Master's degree in STEM

Tools

High-content imaging system

MEA system

Genome editing tools

Job description

Position Summary

A Staff Scientist position is available with a flexible start date within the Human Neuron Core at Boston Children’s Hospital. We are looking for an independent and self‑motivated scientist to join our team and work on projects utilizing human induced pluripotent stem cell (iPSC)-derived neurons to model neurological disease. The researcher will be responsible for differentiating iPSCs into different subtypes of neurons and glia, as well as phenotyping the neurons using various technologies. Opportunities are available to learn new techniques, including high content imaging and analysis, multi‑electrode array recording, and novel genome editing approaches. Qualified candidates should have strong experimental expertise in iPSC tissue culture and neuroscience.

Position Summary

A Staff Scientist position is available with a flexible start date within the Human Neuron Core at Boston Children’s Hospital. We are looking for an independent and self‑motivated scientist to join our team and work on projects utilizing human induced pluripotent stem cell (iPSC)-derived neurons to model neurological disease. The researcher will be responsible for differentiating iPSCs into different subtypes of neurons and glia, as well as phenotyping the neurons using various technologies. Opportunities are available to learn new techniques, including high content imaging and analysis, multi‑electrode array recording, and novel genome editing approaches. Qualified candidates should have strong experimental expertise in iPSC tissue culture and neuroscience.

The mission of the HNC is to use human patient‑derived neurons to model neuronal disease and provide support for preclinical research by developing tools, assays, and screens to identify novel therapeutics. The HNC is situated at Boston Children’s within the Harvard network, in an environment abounding in experts from neuroscience, neurology, and stem cell biology. We are fortunate as well to be abundantly supplied with many of the best clinicians in the world. Thus, the Staff Scientist will join a fast‑paced team that uses cutting edge technology to accelerate therapeutic development for rare neurodevelopmental disorders.

Duties & Responsibilities

• Tissue culture and quality control of human iPSCs and neuron differentiation
• Presentations and communication of results to internal and external research groups
• Independently leading original scientific research projects that can include:
• Calcium imaging assay development
• Development of 3D analysis pipelines
• Differentiation and phenotyping of neurons, including high content imaging and multi‑electrode array recordings
• Assay development and screening
• Keeping good records, following optimized standard operating procedures, and providing input for improvement in methods to stay up to date with the field
• Staying up to date with the literature in the relevant fields
• Mentoring and leading Research Assistants and junior colleagues in the Core
• Preparing manuscripts for publication

Education

Minimum Qualifications

• A master's degree in a STEM-related field in addition 7 years of research experience.

The posted pay range is Boston Children’s reasonable and good‑faith expectation for this pay at the time of posting.

Any base pay offer provided depends on skills, experience, education, certifications, and a variety of other job‑related factors. Base pay is one part of a comprehensive benefits package that includes flexible schedules, affordable health, vision and dental insurance, child care and student loan subsidies, generous levels of time off, 403(b) Retirement Savings plan, Pension, Tuition and certain License and Certification Reimbursement, cell phone plan discounts and discounted rates on T-passes. Experience the benefits of passion and teamwork.

• flexible schedules
• affordable health
• vision and dental insurance
• child care and student loan subsidies
• generous levels of time off
• 403(b) Retirement Savings plan
• Pension
• Tuition and certain License and Certification Reimbursement
• cell phone plan discounts
• discounted rates on T-passes