Sr./Staff Scientist – Surface Chemistry

Sarmal; San Diego (CA); On-site; USD 125,000 - 162,000; Full time

Benefits offered by this job

Medical, Dental, and Vision

Life Insurance

401(k)

Paid Time Off

Job summary

Sarmal is seeking a Senior Scientist to Staff Scientist, Surface Chemist, to drive design, development, and optimization of functionalized surfaces for NGS and molecular diagnostic platforms. This role sits at the interface of chemistry, materials science, and device engineering, delivering robust, manufacturable surface chemistries and enabling high-performance assays.

The ideal candidate brings deep hands-on expertise in surface chemistry, thin-film deposition, and analytical surface

Qualifications

• Experience developing functional surfaces for biomolecular applications.
• Hands-on expertise in surface chemistry methods and thin-film deposition.
• Strong DOE and data interpretation skills.
• Familiar with QC method development for surface characterization.

Responsibilities

• Design, synthesize, and optimize surface chemistries for oligonucleotide/probe immobilization on NGS and IVD platforms.
• Develop and optimize surface functionalization on diverse substrates (glass, silicon, metals, polymers).
• Lead scale-up of surface deposition and patterning processes (PE-CVD, CVD, spin-/dip-/spray coating, plasma treatment).
• Characterize surface chemistry performance with analytical tools and correlate to assay performance.
• Collaborate with cross-functional teams to transition processes to manufacturing under design control.
• Design DOEs to optimize coating uniformity, shelf-life, and lot-to-lot consistency.

Skills

Surface chemistry

DOE

Data interpretation

Analytical techniques

Education

B.S./M.S./Ph.D. in Materials Science

Chemical Engineering background

Tools

PE-CVD

CVD

Spin coating

Dip coating

Spray coating

Photolithography

Inkjet patterning

Job description

Company Overview

Sarmal, Inc. is a San Diego-based biotechnology company developing next-generation genomics and molecular detection platforms. Our work integrates molecular biology, chemistry, and advanced systems engineering to enable faster, more precise, and more accessible genomic insights. We are a highly collaborative, R&D-driven team operating in a fast-paced, early-stage environment. Our scientists and engineers work across disciplines to solve complex technical challenges and translate innovation into scalable, real-world applications. At Sarmal, we value scientific rigor, curiosity, and a builder mindset. We are looking for individuals who are energized by ambiguity, motivated by impact, and excited to help bring breakthrough technologies from concept to reality.

Company Overview

Sarmal, Inc. is a San Diego-based biotechnology company developing next-generation genomics and molecular detection platforms. Our work integrates molecular biology, chemistry, and advanced systems engineering to enable faster, more precise, and more accessible genomic insights. We are a highly collaborative, R&D-driven team operating in a fast-paced, early-stage environment. Our scientists and engineers work across disciplines to solve complex technical challenges and translate innovation into scalable, real-world applications. At Sarmal, we value scientific rigor, curiosity, and a builder mindset. We are looking for individuals who are energized by ambiguity, motivated by impact, and excited to help bring breakthrough technologies from concept to reality.

About The Job

We are seeking a Senior Scientist to Staff Scientist Surface Chemist to drive the design, development, and optimization of functionalized surfaces for next-generation sequencing (NGS), and molecular diagnostic (IVD) platforms. This role sits at the interface of chemistry, materials science, and device engineering, and is responsible for developing robust, manufacturable surface chemistries (including hydrogel, silane, self-assembled monolayers, brush polymer surfaces) for ultra-low fouling, oligonucleotide/probe immobilization, hybridization and various molecular processes. The ideal candidate brings deep hands-on expertise in various surface chemistry methods, thin-film deposition techniques, and a broad analytical toolkit for surface characterization, combined with the ability to troubleshoot chemistry performance in the context of an integrated diagnostic device.

Key Responsibilities

• Design, synthesize, and optimize surface chemistries (hydrogel, silane, self-assembled monolayers, brush polymer surfaces) for oligonucleotide/probe immobilization, amplification, and hybridization chemistries on next-generation sequencing (NGS), and molecular diagnostic (IVD) platforms.
• Develop and optimize surface functionalization processes on diverse substrate materials — glass, silicon, silicon nitride, metals/metal oxides, noble-metal electrodes, polymers, and patterned/micro-structured surfaces.
• Lead development and scale-up of surface deposition and patterning processes, including PE-CVD, CVD, spin-coating, dip-coating, spray-coating, vapor-phase deposition, plasma treatment/activation, and photolithographic/printed patterning methods.
• Characterize surface chemistry performance and quality using a broad suite of analytical techniques, correlating physicochemical properties to assay performance (signal, specificity, uniformity, density, non-specific binding).
• Work closely with electrode-based platform on surface modification of working/reference/counter electrodes and evaluation of electrochemical performance.
• Collaborate cross-functionally with Assay Development, Reagent Chemistry, Device/Instrument Engineering, Manufacturing, and Quality/Regulatory teams to transition surface chemistry processes from R&D through pilot scale-up and into IVD manufacturing under design control.
• Design and execute DOEs to optimize coating uniformity, reproducibility, shelf-life/stability, and lot-to-lot consistency; support root cause investigations and CAPAs related to surface chemistry performance.
• Author and maintain technical reports, protocols, batch records, DHF/design control documentation, and contribute to regulatory submissions (e.g., FDA 510(k)/PMA, CE-IVDR) as needed.
• Maintain awareness of literature and emerging technologies in surface chemistry, biofunctionalization, and diagnostic surface engineering; evaluate new materials/methods for potential adoption.
• Mentor junior scientists and associates; may manage or direct the work of research associates.
• Support IP strategy, including invention disclosures and patent support.
• Contribute to troubleshooting surface performance issues and root-cause analysis.

Qualifications

• Experience in developing functional surfaces for biomolecular applications, ultra-low fouling surfaces, polymer thin-films, hydrogel networks.
• Working knowledge of nucleic acid chemistry and how surface properties affect hybridization thermodynamics, kinetics, etc.
• Surface deposition/patterning methods (PE-CVD, CVD, spin/dip/spray coating, plasma activation/etching, and photolithographic, or inkjet-based patterning.)
• Experience working with electrode surfaces and materials (e.g., gold, platinum, carbon, ITO) and/or electrochemical platforms.
• Experience with a wide range of substrate materials, including glass, silicon/silicon-based substrates, metal/metal-oxide, polymers/plastics, and patterned/micro-structured or micro-fabricated surfaces.
• Strong DOE, statistical analysis, and data interpretation skills.
• Solid empirical knowledge of bioconjugations in the context of microarrays and biointerfaces.
• Hands-on experience with analytical surface characterization methods:
• Contact angle goniometry / surface energy analysis
• X-ray photoelectron spectroscopy (XPS)
• Atomic force microscopy (AFM)
• Scanning electron microscopy (SEM) / SEM-EDS
• Ellipsometry (film thickness/uniformity)
• Fourier-transform infrared spectroscopy (FTIR, incl. ATR-FTIR)
• Quartz crystal microbalance (QCM-D)
• Profilometry (surface roughness/topography)
• Electrochemical impedance spectroscopy (EIS) / cyclic voltammetry (CV)
• Fluorescence-based surface density/uniformity assays
• Zeta potential & surface charge characterization
• Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS)
• Excellent written and verbal communication skills; ability to present technical results to cross-functional and leadership audiences.
• Familiarity with QC method development for surface characterization.

Preferred Qualifications

• Direct experience developing surface chemistry for NGS flow cells, IVD consumables, or microarray substrates in a regulated IVD or medical device environment.
• Experience with design controls (21 CFR 820.30 / ISO 13485) and transfer of chemistry/processes to manufacturing.
• Experience with cleanroom processes and semiconductor-adjacent fabrication techniques.
• Familiarity with biosensor or point-of-care diagnostic platform development.

Education

• B.S., M.S., or Ph.D. degree in Materials Science, Surface Chemistry, Polymer Chemistry, Chemical Engineering, or related field.
• Minimum experience of 7 years with B.S., 5 years with M.S., or 3 years with Ph.D.

Benefits & Perks

• Medical, dental, and vision coverage
• Company-paid life insurance
• 401(k) retirement plan
• Generous paid time off
• Access to additional voluntary benefits, employee perks, and discount programs
• We are committed to supporting the well-being of our employees and providing a strong foundation for both professional and personal success.

$125,000 - $162,000 a year

California Pay Transparency Statement

The anticipated salary range for this position is $125,000 - $162,000, depending on experience and qualifications. Final compensation will be determined based on a variety of factors including, but not limited to, location, relevant experience, skill set, and internal equity considerations.

EEO Statement

Sarmal is an equal opportunity employer committed to building a diverse and inclusive workplace. We do not discriminate based on race, color, religion, sex, gender identity or expression, sexual orientation, national origin, ancestry, age, disability, medical condition, genetic information, marital status, veteran status, or any other characteristic protected by applicable federal, state, or local laws.

Reasonable Accommodation Statement

Sarmal is an equal opportunity employer that values diversity and inclusion. We welcome applicants of all backgrounds and consider all qualified candidates in accordance with applicable laws.

Why Join Sarmal

• Work on cutting-edge genomics and molecular detection technologies
• Collaborate with a deeply technical, cross-functional team
• Contribute to foundational platform development at an early stage
• Have visibility into and impact on core technical and strategic decisions
• Help shape the infrastructure, culture, and future direction of the company

Closing Statement

Join us in advancing the next generation of genomic technologies and shaping the future of precision health.

We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses and identifying potential inconsistencies or verification signals in application materials based on available information. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.