Sr. Research Associate -Systems Integration

Sarmal; San Diego (CA); On-site; USD 72,000 - 85,000; Full time

Benefits offered by this job

Medical, dental, and vision coverage

Company-paid life insurance

401(k) retirement plan

Generous paid time off

Access to additional voluntaryBenefits

Job summary

Sarmal, Inc. in San Diego invites applications for a Senior Research Associate to drive systems integration for our molecular diagnostics platform.

This role sits at the interface of molecular biology and engineering, translating bench-scale processes into automated, sample-to-answer workflows for instrument platforms and consumables. You will collaborate with Assay Development, Reagent Chemistry, Device/Instrument Engineering, Manufacturing and Quality/Regulatory teams to optimize fluidics,

Qualifications

• BS/MS in Biomedical Engineering, Chemical Engineering, Bioengineering, Molecular Biology, Chemistry, or related field
• 5+ years of relevant industry experience or equivalent
• Hands-on experience with immature hardware and iterative design cycles
• Fluorescence imaging and/or fluorescence spectroscopy instrumentation
• Experience with fluidic and flow cell–based systems
• Experience in regulated environments (GMP, ISO 13485, FDA design controls) and design history files

Responsibilities

• Build, characterize, and iterate on early prototype instrument and consumable systems with cross-functional teams
• Lead integration testing, risk analysis, and troubleshooting across development cycles
• Characterize consumable performance across lots and design iterations
• Support fluidics and flow cell-based system troubleshooting and design improvements
• Operate fluorescence-based detection systems and evaluate performance metrics
• Translate bench-scale processes into integrated workflows for instrument platforms
• Define and execute integration testing protocols spanning fluidics, electronics, and assay chemistry
• Maintain rigorous documentation for design history files and regulatory submissions
• Collaborate with quality and regulatory to align with GMP/ISO/FDA design controls
• Contribute to design-for-manufacturability and design-for-reliability discussions
• Collaborate to transition surface chemistry processes from R&D to pilot scale and IVD manufacturing
• Design and execute DOEs to optimize coating uniformity and stability; support CAPAs
• Author technical reports, batch records, and DHF/design control documentation
• Support IP strategy and patent disclosures
• Present data and recommendations to cross-functional teams

Skills

Biomedical engineering

Hands-on lab skills

Fluorescence imaging

Flow cell / microfluidics

GMP / ISO 13485 knowledge

Molecular biology techniques

Education

BS/MS in Biomedical Engineering, Chemical Engineering, Bioengineering, Molecular Biology, Chemistry, or related field

Tools

Automated liquid-handling systems

Job description

Company Overview

Sarmal, Inc. is a San Diego–based biotechnology company developing next-generation genomics and molecular detection platforms. Our work integrates molecular biology, chemistry, and advanced systems engineering to enable faster, more precise, and more accessible genomic insights.

Company Overview

Sarmal, Inc. is a San Diego–based biotechnology company developing next-generation genomics and molecular detection platforms. Our work integrates molecular biology, chemistry, and advanced systems engineering to enable faster, more precise, and more accessible genomic insights.

We are a highly collaborative, R&D-driven team operating in a fast-paced, early-stage environment. Our scientists and engineers work across disciplines to solve complex technical challenges and translate innovation into scalable, real-world applications.

At Sarmal, we value scientific rigor, curiosity, and a builder mindset. We are looking for individuals who are energized by ambiguity, motivated by impact, and excited to help bring breakthrough technologies from concept to reality.

About The Job

We are seeking a Senior Research Associate to drive systems integration efforts for our molecular diagnostics platform. This role sits at the interface of molecular biology and engineering and is responsible for the transition and optimization of molecular and biochemical processes onto automated sample-to-answer molecular diagnostic instrument platform and consumable.

Key Responsibilities

• Build, characterize, and iterate on early prototype instrument and consumable systems, working closely with engineering, assay development, and chemistry teams.
• Lead integration testing, risk analysis, and troubleshooting across development cycles.
• Design and execute studies to characterize consumable performance (e.g., flow cell fluidics, reagent cartridges, sample prep modules) across manufacturing lots and design iterations.
• Support development and troubleshooting of fluidic and flow cell–based systems, including flow path design, priming/wetting behavior, bubble management, dead volume, and flow uniformity.
• Operate and troubleshoot fluorescence-based detection systems (imaging or plate-reader based), evaluating performance using metrics such as signal intensity, background, specificity, sensitivity, and reproducibility.
• Translate bench-scale sample preparation, molecular processes and detection chemistries into integrated, system-compatible workflows.
• Define and execute integration testing protocols spanning fluidics, electronics/instrumentation, and assay chemistry to identify failure modes and performance bottlenecks.
• Generate and maintain rigorous documentation (protocols, data records, technical reports) suitable for design history files and regulatory submissions.
• Collaborate with quality and regulatory functions to ensure development work aligns with GMP/ISO/FDA design control requirements as the program advances toward verification and validation.
• Contribute to design-for-manufacturability and design-for-reliability discussions for consumable and instrument subsystems.
• Collaborate cross-functionally with Assay Development, Reagent Chemistry, Device/Instrument Engineering, Manufacturing, and Quality/Regulatory teams to transition surface chemistry processes from R&D through pilot scale-up and into IVD manufacturing under design control.
• Design and execute DOEs to optimize coating uniformity, reproducibility, shelf-life/stability, and lot-to-lot consistency; support root cause investigations and CAPAs related to surface chemistry performance.
• Author and maintain technical reports, protocols, batch records, DHF/design control documentation, and contribute to regulatory submissions (e.g., FDA 510(k)/PMA, CE-IVDR) as needed.
• Support IP strategy, including invention disclosures and patent support.
• Present data and recommendations to cross-functional project teams and leadership.

Qualifications

Required Qualifications

• BS/MS in Biomedical Engineering, Chemical Engineering, Bioengineering, Molecular Biology, Chemistry, or related field, with 5+ years of relevant industry experience (or equivalent combination of education and experience)
• Demonstrated experience in product development with early prototype systems — comfortable working with immature hardware, ambiguous specs, and iterative design cycles
• Hands-on experience with consumable characterization — designing test methods, defining acceptance criteria, and driving root-cause analysis on consumable performance issues
• Hands-on experience with fluorescence imaging and/or fluorescence spectroscopy instrumentation, including image/data analysis for signal characterization
• Experience working with fluidic and/or flow cell–based systems (microfluidics, cartridge-based systems, or similar) — understanding of flow behavior, fluid handling, and common failure modes
• Experience working in a regulated environment (GMP, ISO 13485, FDA design controls) with familiarity in documentation practices supporting design history files and quality systems
• Working knowledge of molecular biology techniques relevant to nucleic acid-based diagnostics (nucleic acid extraction/purification, PCR or isothermal amplification, sample preparation workflows)
• Strong hands-on laboratory skills, meticulous record-keeping, and the ability to troubleshoot systematically across chemistry, biology, and hardware domains
• Excellent written and verbal communication skills; ability to synthesize data into clear reports for cross-functional audiences.

Preferred Qualifications

• Experience with in vitro diagnostics (IVD) product development, particularly molecular diagnostics or point-of-care platforms.
• Experience with automated liquid-handling systems is a plus
• Familiarity with whole blood sample handling, including cell lysis, nucleic acid depletion/enrichment strategies, or blood-based sample stabilization/cryopreservation.
• Experience supporting verification and validation (V&V) activities or transfer to manufacturing.
• Statistical data analysis skills (e.g., JMP, Minitab, Python/R) for characterization and DOE studies.

Education

BS/MS in Biomedical Engineering, Chemical Engineering, Bioengineering, Molecular Biology, Chemistry, or related field, with 5+ years of relevant industry experience (or equivalent combination of education and experience)

Benefits & Perks

Sarmal offers a competitive and comprehensive benefits package, including:

• Medical, dental, and vision coverage
• Company-paid life insurance
• 401(k) retirement plan
• Generous paid time off
• Access to additional voluntary benefits, employee perks, and discount programs
• We are committed to supporting the well-being of our employees and providing a strong foundation for both professional and personal success.

$72,000 - $85,000 a year

California Pay Transparency Statement.

The anticipated salary range for this position is $72,000 – $85,000, depending on experience and qualifications. Final compensation will be determined based on a variety of factors including, but not limited to, location, relevant experience, skill set, and internal equity considerations.

EEO Statement

Sarmal is an equal opportunity employer committed to building a diverse and inclusive workplace. We do not discriminate based on race, color, religion, sex, gender identity or expression, sexual orientation, national origin, ancestry, age, disability, medical condition, genetic information, marital status, veteran status, or any other characteristic protected by applicable federal, state, or local laws.

Reasonable Accommodation Statement

Sarmal is an equal opportunity employer that values diversity and inclusion. We welcome applicants of all backgrounds and consider all qualified candidates in accordance with applicable laws.

Why Join Sarmal

• Work on cutting-edge genomics and molecular detection technologies
• Collaborate with a deeply technical, cross-functional team
• Contribute to foundational platform development at an early stage
• Have visibility into and impact on core technical and strategic decisions
• Help shape the infrastructure, culture, and future direction of the company

Closing Statement

Join us in advancing the next generation of genomic technologies and shaping the future of precision health.

We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses and identifying potential inconsistencies or verification signals in application materials based on available information. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.