Sr. Software Engineer (Contract-to-Hire)

Vibehackers; South San Francisco (CA); On-site; USD 150,000 - 210,000; Full time

Benefits offered by this job

Meaningful early-stage equity

Contract rate commensurate with опыт

Job summary

Vibehackers is seeking a Senior Software Engineer for a contract-to-hire role in South San Francisco, CA. You will build AI-driven tools, visualizations, and integrations for a computational platform modeling brain health and neurodegeneration.

The role emphasizes agentic workflows, LLM integrations, and scalable software for model-enabled research and drug discovery, with on-site office presence one day per week and periodic travel for remote candidates.

Qualifications

• BS in CS, Engineering, or related field.
• 5+ years software development experience.
• Experience vibe coding with frontier models.
• Proficient in Python and JSON; API integrations.
• Strong, well-documented code and docs.
• Thrives in fast-moving startup with multiple priorities.

Responsibilities

• Develop AI-driven tools, agentic workflows, and MCP-based integrations.
• Build AI-enabled visualizations, dashboards, and automated parametric search tools.
• Integrate and analyze external literature and data into the modeling platform.
• Turn concepts and prototypes into scalable, extensible software solutions.
• Document requirements, architecture and workflow descriptions, API documentation.

Skills

Python

JSON

API design

Documentation

Problem solving

AI/ML tooling

Chat-based interactions

Agentic workflows

Education

BS in Computer Science / Engineering / related

Tools

LLM APIs

RAG

MCP

Open-weight LLMs

Job description

Sr. Software Engineer (Contract-to-Hire)

Explicitly requires vibe coding skills and building AI-assisted, agentic workflows and LLM integrations for scientific tooling.

About the Role

Senior software engineer to build AI-driven tools, visualizations, and integrations for a computational platform modeling brain health and neurodegeneration. Role focuses on developing agentic workflows, LLM integrations, and scalable software to support model-enabled research and drug discovery.

Job Description

Role

Reporting to the CTO, this hands-on Senior Software Engineer will develop AI-driven tools and infrastructure to enable biological models, digital populations, digital twins, and model-enabled research. The role emphasizes building agentic workflows, chat-based interactions, LLM integrations, visualizations, dashboards, and automated parametric search tools that can operate autonomously or with human-in-the-loop.

Key Responsibilities

• Develop AI-driven tools and skills including chat-based interactions, agentic workflows, and MCP-based integrations to support model development and analysis.
• Build AI-enabled visualizations, dashboards, and automated parametric search tools for complex, iterative workflows.
• Integrate and analyze external literature and data into the modeling platform.
• Turn concepts and prototypes into scalable, extensible software solutions.
• Capture requirements from technical discussions and produce clear documentation (commented code, architecture and workflow descriptions, API documentation).

Qualifications

Required

• BS in Computer Science, Engineering, or related discipline.
• 5+ years developing software in a professional environment.
• Experience vibe coding with one or more frontier models.
• Proficient in Python and JSON; experience interfacing with API-driven platforms.
• Demonstrated skill producing well-designed, well-documented code and supporting documentation.
• Comfortable working in a fast-moving startup environment and juggling multiple priorities.

Highly Desired

• Experience developing scientific, modeling, or analytical software.
• Experience developing AI skills for agentic workflows and integrating with LLMs (LLM APIs, RAG, MCP).
• Experience using open-weight (local) LLM models.
• Familiarity with Bayesian statistics and simulation of non-linear differential equation systems.

Work Arrangement

• Full-time, contract-to-hire (intended path to full-time employment).
• Ideal candidate based in the San Francisco Bay Area and able to work at the South San Francisco, CA office one day per week. Remote candidates willing to periodically travel to South San Francisco will be considered.

What We Offer

• Meaningful early-stage equity and a contract rate commensurate with experience.
• Opportunity to build modeling tools supporting research into Alzheimer’s and related neurodegenerative diseases at an early-stage company.

Python JSON Mathematica LLM APIs RAG MCP open-weight LLMs API-driven platforms

Skills

Software Development API Design Requirements Analysis Technical Documentation Collaboration Problem Solving AI/ML Tooling Data Integration Human-in-the-loop System Design Rapid Prototyping

Experience Level

Senior

Employment Type

Contract

• Meaningful early-stage equity
• Contract-to-hire (path to full-time)
• Contract rate commensurate with experience
• Opportunity to work on neurodegenerative disease researchFlexible/remote candidates considered with periodic travel to South San Francisco
• Office presence one day per week in South San Francisco, CA