Sr. Software Engineer

Prenosis; Chicago (IL); On-site; USD 140,000 - 190,000; Full time

Job summary

Prenosis is seeking a hands-on Senior Software/SRE Engineer to design and implement production-grade Go and Python services, and lead architecture decisions in a HIPAA-regulated environment. You will work across backend, frontend, and Kubernetes infrastructure to ensure reliability and security.

You will own full-stack delivery with a focus on scalable cloud infrastructure (AWS/GCP), monitoring, and CI/CD automation, contributing extensively to code reviews, ADRs, and deployment tooling.

Responsibilities

• Write production-quality Go and Python backend services: APIs, data pipelines, business logic, and integrations.
• Build and maintain TypeScript/React frontend features with focus on UI quality and performance.
• Conduct deep, substantive code reviews to raise codebase quality.
• Drive architectural decisions and prototypes to validate direction.
• Champion HIPAA compliance and security best practices in code, data handling, auth, encryption, and audits.
• Ensure availability and reliability; pre-emptively address failure points affecting user workflows.
• Implement and maintain comprehensive monitoring, logging, and alerting with Prometheus, Kibana, Elastic Stack, or OpenTelemetry.
• Develop and maintain CI/CD pipelines (GitHub Actions, GitLab) for safe and efficient deployments.
• Drive SDLC improvements: branches, tests, progressive delivery, rollbacks.
• Embed HIPAA controls into pipelines for automated verification.

Skills

Go

Python

TypeScript

CI/CD concepts

System design

Cloud architecture

HIPAA security awareness

Tools

Kubernetes

Terraform

GitHub Actions

Prometheus

Kibana/OpenTelemetry

ArgoCD

Helm

OpenTelemetry

Job description

About Prenosis

Prenosis Inc. is an artificial intelligence company pioneering precision medicine in acute care. Our Immunix™ precision medicine platform drives the development of precision products and enables real-time delivery of optimal therapy. We've created and validated the first FDA-authorized AI biomarker for sepsis, the Sepsis ImmunoScore®.

At Prenosis, we:

• Put patients first
• Disrupt with evidence
• Excel with integrity
• Go far together

Our staff collectively defined these corporate values to demonstrate how our teams contribute to meaningful and authentic change in U.S. healthcare. We value our diverse talent, stride to foster a culture of continuous learning, and aim to maintain a feeling of belonging and shared sense of purpose.

Prenosis is headquartered in Chicago Illinois and generally operates on Central Time Zone.

Position Summary

We are looking for a hands-on Senior Software/SRE Engineer who spends the majority of their time writing and reviewing production code. You will be a primary technical contributor on the team, designing systems, closing pull requests, debugging production incidents, and setting the technical bar through example. Roughly 80% of your time will be spent on individual technical contribution and architecture; the remaining 20% on the functional management responsibilities that keep a small, high-performing team running smoothly.

You will work across our Go backend services, Python APIs, TypeScript frontend, and Kubernetes infrastructure. Owning full-stack delivery in a HIPAA-regulated environment where correctness and reliability are non-negotiable.

Responsibilities

• Write production-quality Go and Python backend services: APIs, data pipelines, business logic, and integrations.
• Build and maintain TypeScript/React frontend features with real attention to UI quality and client-side performance.
• Conduct deep, substantive code reviews that raise the technical quality of the entire codebase.
• Drive architectural decision records (ADRs) and hands-on prototypes to validate technical direction before committing the team.
• Champion HIPAA compliance and security best practices at the code level - in data handling, auth, encryption, and audit logging.
• Ensure the availability and reliability of applications and systems; proactively identify and address potential failure points before they affect patient-facing workflows.
• Implement and manage comprehensive monitoring, logging, and alerting using Prometheus, Kibana, the Elastic Stack, OpenTelemetry, or equivalent tools.
• Partner with other developers to design, implement, and maintain CI/CD pipelines (GitHub Actions, GitLab, or equivalent) that streamline development workflows and deployment safety.
• Drive SDLC improvements: branch strategies, automated testing gates, progressive delivery, and rollback procedures.
• Embed security and compliance checks into pipelines so HIPAA controls are verified automatically, not manually.
• Maintain cloud infrastructure on AWS and GCP - ensuring scalability, high availability, and cost efficiency.
• Manage infrastructure as code using Terraform/Terragrunt; maintain clean, version-controlled, peer-reviewed infrastructure changes.
• Manage Kubernetes clusters across AWS (EKS) and GCP (GKE); tune resource limits, manage rollouts, and operate services at scale.
• Implement and maintain deployment tooling - Helm, Kustomize, ArgoCD, Flux - to optimize workload management and enable GitOps workflows.
• Debug misbehaving workloads, manage cluster upgrades, and drive operational maturity across the platform.

Expected frequency and duration of travel: 2-3 times a year