Sr. Scientist, Translational Medicine

The Steely Group; Cambridge (MA); On-site; USD 110,000 - 160,000; Full time

Job summary

A leading company in the pharmaceutical and biotechnology sector is seeking a Senior Scientist to join their Translational Medicine and Integrated Research team in Cambridge, MA. The role focuses on biomarker discovery and clinical assay development to support allergy and immunology programs. The ideal candidate will possess a PhD and have significant experience in translational research, demonstrating strong analytical and communication skills. This position offers the opportunity to contribute to innovative projects in a fast-paced environment.

Qualifications

• PhD in Molecular biology, cell biology, or related discipline.
• 4-6 years relevant experience in a biopharmaceutical research setting.
• Minimum of 2 years translational, clinical research experience.

Responsibilities

• Define and execute translational and biomarker plans for allergy and immunology programs.
• Perform experimental design, lab-based research, data analysis, and integration.
• Manage external biomarker analysis at specialty CROs.

Skills

Interpersonal skills

Communication skills

Analytical skills

Education

PhD in Molecular Biology or related discipline

Tools

PCR

NGS

Western blotting

Job description

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The Translational Medicine and Integrated Research (TMIR) team is seeking a highly motivated, scientifically creative, and collaborative Senior Scientist to work in a fast-paced environment within a cross-functional team.

The successful candidate will be a highly motivated scientist, dedicated to biomarker discovery, clinical biomarker assay development, implementation, and interpretation to help advance our allergy and immunology pipeline. This candidate will be responsible for developing and executing integrated biomarker strategies utilizing state-of-the-art technologies.

A strong understanding of immunology, molecular mechanism in allergies and inflammation, and the ability to analyze and interpret complex data sets will be key strengths. This candidate will have the opportunity to contribute scientifically across the portfolio to programs at various discovery and development stages, ranging from discovery to clinical.

Responsibilities:

• Define and execute translational and biomarker plans for preclinical and clinical-stage allergy and immunology programs with a focus on mechanism of action, target engagement, establishment of PK/PD/efficacy relationships, patient selection strategies and understanding mechanisms of intrinsic and acquired resistance.
• Ensure that discovery, pre-clinical and clinical biomarker plans are developed and implemented efficiently and aligned with the strategic needs of the program.
• Perform and/or oversee experimental design, lab-based research, data analysis, data integration and data storage. Independently conduct, optimize, and proactively troubleshoot assays both in-house and with CRO.
• Manage external biomarker analysis at specialty CROs including experimental design, validation, qualification, budgeting, timelines, and oversight of quality and execution during trial conduct.
• Represent Translational Medicine within project/program teams; share scientific and strategic perspectives, generate data to support team needs, and meet project/program milestones for TM responsibilities.
• Contribute to the development of clinical protocols, laboratory manuals, regulatory submissions, abstracts, and publications.
• Analyze, interpret, and present integrated scientific results and implications for program strategy to internal and external stakeholders.
• Effectively collaborate across internal functions including discovery, translational, clinical pharmacology, clinical development, data management to ensure successful execution in the clinic.
• Clearly communicate translational strategies, timelines, dependencies, risks, and mitigations to team members.
• Evaluate new technologies and partner with external collaborators to enable exploratory biomarkers
• Regularly present research to Translational Medicine and integrated project teams highlighting implications and opportunities for broader program.

Minimum Requirements/Qualifications:

• PhD in Molecular biology, cell biology, with focus on allergy and/or Immunology research, or related discipline
• Relevant post-doctoral training and/or 4-6 years of relevant experience in a biopharmaceutical research setting
• Minimum of 2 years translational, clinical research experience
• Direct research experience in Allergy, Asthma, Anaphylaxis and/or related diseases
• Strong interpersonal and communication skills, with a passion for participating in a fast-paced environment characterized by challenging and rigorous science, and innovative thinking
• Demonstrated knowledge of clinically relevant biomarker approaches across a range of technology platforms and relevant disease indications
• Experience working with central laboratories and contract research organizations supporting specialized biomarker analysis
• Familiarity with working in the GxP environment with a focus on quality

What additional qualifications will make you a stronger candidate?

• Hands-on experience with molecular and cellular assay development, validation, and data analysis is preferred (e.g., PCR, NGS, Western blotting).
• Hands-on experience in multiplex IHC/IF and cytokine assay development and analysis.
• Extensive experience with state-of-the-art assays and standard analytical software tools (e.g., Excel, Prism, etc.).
• Familiarity with PK/PD/efficacy relationships and delivering PD readouts.
• Strong oral and written communication skills, with a demonstrated ability to share scientific knowledge.
• Excellent documentation and organizational skills.
• A great teammate who listens effectively and invites responses and discussion.
• A collaborator who communicates in an open, clear, complete, timely, and consistent manner.

Seniority level

• Seniority level

  Not Applicable

Employment type

• Employment type

  Contract

Job function

• Job function

  Science

• Industries

  Pharmaceutical Manufacturing and Biotechnology Research

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