Sr. Scientist - Mass Spec Development

Kcas, Llc; Kansas City (MO); On-site; USD 80,000 - 110,000; Full time

Benefits offered by this job

Company sponsored events

Career development through KCAS University

Stock ownership program

Paid time off to volunteer

Job summary

A key player in bioanalysis is seeking a Sr. Scientist to join their team in Kansas City, Missouri. This role involves designing and executing bioanalytical projects, training junior scientists, and ensuring compliance with study protocols. Candidates must have a degree in Chemistry or related field and at least 5 years of experience in LC-MS/MS. The company offers a dynamic work environment, opportunities for professional development, and a comprehensive benefits package including stock ownership and volunteer time off.

Qualifications

• At least 5 years of experience with LC-MS/MS.
• Experience with proteins, peptides, and small molecule biomarkers preferred.
• 2-3 years of experience in a Principal Investigator role.

Responsibilities

• Design and execute all phases of assigned projects including sample preparation.
• Act as lead scientist and provide technical training to junior staff.
• Be responsible for all client communication related to study conduct.
• Interact with QAU to resolve audit issues.
• Ensure compliance of study activities with protocols and regulations.
• Prepare data summaries for senior scientists.

Skills

LC-MS/MS

Bioanalytical sample preparation

Principal Investigator experience

Quantitative LC-MS/MS

Multi-dimensional chromatography

Education

Bachelor’s, Master’s, or PhD in Chemistry, Biochemistry or related field

Job description

KC - Mass Spectrometry Bioanalysis - Dev

Performing critical work that impacts our industry and our world’s health while problem solving and innovating in the field – that is what Sr. Scientists at KCAS Bio get to do every day. If that gets you excited too, then maybe working as a Sr. Scientist at KCAS Bio is the role for you.

When you work as a Sr Scientist in the Mass Spec Bioanalysis Development group at KCAS, you get to further our mission by leveraging your knowledge in bioanalytical and scientific principles to be responsible carrying out all aspects of a study, from study set‑up through reporting, as well as development. You will also utilize your strong base in scientific principles and theories to assess data integrity and troubleshoot when necessary.

Our Mass Spec Bioanalysis Development team uses LCMS (Liquid Chromatography Mass Spectrometry) techniques to conduct sophisticated sample preparation to meet bioanalytical needs for drug discovery, preclinical, and clinical studies, including bioanalysis of drugs and metabolites, biomarkers, and active endogenous compounds in biological fluids and tissues.

In this role, we will rely on you to:

• Design and execute all phases of assigned projects including sample preparation (extractions, enrichments/affinity capture, digestions), method development and qualification for LCMS, troubleshooting, data analysis, and report generation.
• Act as lead scientist, help to design experiments, provide work instructions and technical training to more junior scientific staff in daily activities.
• Be responsible for all client communication related to study conduct.
• Interact with QAU to resolve identified audit issues and is accountable for continuous quality management in assigned studies.
• Have final authority for sample identification, including clinical site discrepancies and/or client.
• Be responsible for timeline adherence and communication of status to management as required.
• Ensure compliance of study activities with pertinent portion of study protocol, SOPs & regulatory requirements.
• Be able to set up and change instrument configurations for various LCMS methods.
• Prepare data summaries for senior scientists to aid in client updates.
• Act as a technical expert for all aspects of process design and problem solving.
• Perform all aspects of the job in a way that supports company brand and supports company mission, vision, and values.

To qualify specifically for this role, you will have:

• Bachelor’s, Master’s, or PhD in Chemistry, Biochemistry or chemical/biochemical engineering, or related field with at least 5 years of experience with LC-MS/MS.
• 2‑3 years of experience in a Principal Investigator role.
• Bioanalytical sample preparation, quantitative LC‑MS/MS, and multi‑dimensional chromatography.
• Experience with proteins and peptides as well as small molecule biomarkers is preferred.
• Experience with Reversed Phase and HILIC chromatography at the analytical and micro/nano flow rates or protein digestions and immunoaffinity enrichments (hybrid LCMS) is a plus.

(Please note this is a representative summary of responsibilities, not a comprehensive or exclusive list of the duties to be performed in any position. Employees must follow instructions and perform additional duties as requested.)

WHO YOU ARE

You will thrive at KCAS Bio if you enjoy a relational environment, are purpose‑and values‑driven, embrace constant development and supportive leadership, and enjoy being part of innovative work.

WHAT YOU’LL GET

Our benefits include, and extend beyond, the traditional package. At KCAS Bio, you will enjoy company sponsored events like food trucks, family days and spirit days. You will grow in your career with KCAS University. You will be able to connect with like‑minded employees to further KCAS Bio’s approach to key areas such as wellness, inclusion, and community outreach. You will engage as an owner in our stock ownership program. You will have access to the latest technology. And you will be able to invest in the community with paid time off to volunteer.

KCAS Bio is proud to be an Equal Opportunity Employer. Among other things, we provide equal employment opportunities without regard to race, color, religion, national origin, ancestry, marital status, veteran status, age, disability, pregnancy, genetic information, sex, sexual orientation, gender identity, or any other legally protected category; we recruit qualified candidates without regard to citizenship status based on internal processes that enable us to hire the right candidates consistent with the appropriate U.S. Immigration framework; and (3) we work with and provide reasonable accommodations to individuals with disabilities and for sincerely held religious beliefs, observances, and practices. Anyone who needs reasonable accommodation may send an email to [e-mail] or call 913‑248‑3000 (for TTY assistance call 711) and ask for Human Resources.