Sr. Scientist - Mass Spec Development (LC-MS/MS)

KCAS Bio; Kansas City (MO); On-site; USD 80,000 - 120,000; Full time

Benefits offered by this job

Company sponsored events

Stock ownership program

Paid time off to volunteer

Job summary

A growing contract research organization in Kansas City is seeking a Sr. Scientist to lead projects in Mass Spec Bioanalysis Development. You will utilize your extensive experience in LC-MS/MS to design studies, ensure data integrity, and communicate with clients. Ideal candidates will have a background in chemistry or a related field with at least 5 years of relevant experience. The role emphasizes innovation and teamwork within a supportive setting that offers career growth opportunities.

Qualifications

• Minimum of 5 years of experience with LC-MS/MS technology.
• 2-3 years of experience in a Principal Investigator role.
• Familiarity with reversed phase and Hilic chromatography is preferred.

Responsibilities

• Design and execute phases of projects including method development.
• Act as a lead scientist and provide training to junior staff.
• Ensure compliance with study protocols, SOPs, and regulatory requirements.
• Prepare data summaries for client updates.

Skills

LC-MS/MS expertise

Bioanalytical sample preparation

Quantitative analysis

Chromatography techniques

Problem-solving

Education

Bachelor’s, Master’s, or PhD in Chemistry or related field

Job description

Overview

Performing critical work that impacts our industry and our world’s health while problem solving and innovating in the field – that is what Sr. Scientists at KCAS Bio get to do every day. If that excites you too, then maybe working as a Sr. Scientist at KCAS Bio is the role for you. When you work as a Sr Scientist in the Mass Spec Bioanalysis Development group at KCAS, you get to further our mission by leveraging your knowledge in bioanalytical and scientific principles to be responsible for carrying out all aspects of a study, from study setup through reporting, as well as development. You will also utilize your strong base in scientific principles/theories to assess data integrity and troubleshoot when necessary. Our Mass Spec Bioanalysis Development team uses LCMS (Liquid Chromatography Mass Spectrometry) techniques to conduct sophisticated sample preparation to meet bioanalytical needs for drug discovery, preclinical, and clinical studies, including bioanalysis of drugs and metabolites, biomarkers, and active endogenous compounds in biological fluids and tissues.

Responsibilities

• Design and execute all phases of assigned projects including sample preparation (extractions, enrichments/affinity capture, digestions), method development and qualification for LCMS, troubleshooting, data analysis, and report generation.
• Act as lead scientist, help to design experiments, provide work instructions and technical training to more junior scientific staff in daily activities.
• Be responsible for all client communication related to study conduct.
• Interact with QAU to resolve identified audit issues and be accountable for continuous quality management in assigned studies.
• Have final authority for sample identification, including clinical site discrepancies and/or client.
• Be responsible for timeline adherence and communication of status to management as required.
• Ensure compliance of study activities with pertinent portion of study protocol, SOPs & regulatory requirements.
• Be able to set up and change instrument configurations for various LCMS methods.
• Prepare data summaries for senior scientists to aid in client updates.
• Act as a technical expert for all aspects of process design and problem solving.
• Perform all aspects of the job in a way that supports company brand and mission, vision, and values.

Qualifications

• Bachelor’s, Master’s, or PhD in Chemistry, Biochemistry or chemical/biochemical engineering, or related field with at least 5 years of experience with LC-MS/MS
• 2-3 years of experience in a Principal Investigator role
• Bioanalytical sample preparation, Quantitative LC-MS/MS, and multi-dimensional chromatography
• Experience with proteins and peptides as well as small molecule biomarkers is preferred
• Experience with Reversed Phase and Hilic chromatography at the analytical and micro/nano flow rates or protein digestions and immunoaffinity enrichments (hybrid LCMS) is a plus

About KCAS Bio

Please note this is a representative summary of responsibilities, not a comprehensive or exclusive list of the duties to be performed in any position. Employees must follow instructions and perform additional duties as requested.

Who you are

You will thrive at KCAS Bio if you enjoy a relational environment, are purpose- and values-driven, embrace constant development and supportive leadership, and enjoy being part of innovative work.

What you’ll get

Our benefits include, and extend beyond, the traditional package. At KCAS Bio, you will enjoy company sponsored events like food trucks, family days and spirit days. You will grow in your career with KCAS University. You will be able to connect with like-minded employees to further KCAS Bio\'s approach to key areas such as wellness, inclusion, and community outreach. You will engage as an owner in our stock ownership program. You will have access to the latest technology. And you will be able to invest in the community with paid time off to volunteer.

Who we are

We are a fast-growing contract research organization (CRO) headquartered in Kansas City, pioneering the latest drug development in both human and animal health fields. Demand for our expertise is growing and so is our need for great people to work in nimble, empowered teams committed to one another’s growth. At KCAS Bio, we advance both great science AND great people.

KCAS Bio is proud to be an Equal Opportunity Employer. Among other things, we provide equal employment opportunities without regard to race, color, religion, national origin, ancestry, marital status, veteran status, age, disability, pregnancy, genetic information, sex, sexual orientation, gender identity, or any other legally protected category; we recruit qualified candidates without regard to citizenship status based on internal processes that enable us to hire the right candidates consistent with the appropriate U.S. Immigration framework; and we work with and provide reasonable accommodations to individuals with disabilities and for sincerely held religious beliefs, observances, and practices. Anyone who needs reasonable accommodation may contact our Human Resources department for assistance.