Sr Project Manager - Full Service

Syneos Health; United States; On-site; USD 110,000 - 150,000; Full time

Job summary

Syneos Health is seeking a Senior Project Manager to lead clinical operations across trials from startup to closeout, coordinating cross-functional teams and managing budgets to ensure on-time, compliant delivery.

The role requires hands-on trial execution, strong client liaison skills, and experience with Phase II/III studies in a CRO setting. A Bachelor’s degree in life sciences is required, with a focus on quality and regulatory standards.

Qualifications

• Bachelor degree or equivalent in Life Sciences or related field.
• CRO experience required.
• Proven experience managing trials end-to-end.
• Hands-on trial execution and budgeting experience.

Responsibilities

• Independently manage clinical studies from startup through closeout.
• Lead operational and financial execution of Phase II/III trials.
• Act as primary sponsor liaison and manage stakeholder meetings.
• Ensure studies comply with GCP, ICH guidelines and SOPs.
• Oversee timelines, budgets, resources, risks and deliverables.
• Mentor junior project managers and support staff.
• Support business development opportunities through project delivery.

Skills

Project management

Cross-functional leadership

Budget management

Client/stakeholder management

Mentoring/people leadership

Regulatory compliance (GCP/ICH)

Education

Bachelor's degree in Life Sciences or related field

Job description

Sr Project Manager - Full Service Syneos Health® is a leading fully integrated biopharmaceutical solutions organization built to accelerate customer success. We translate unique clinical, medical affairs and commercial insights into outcomes to address modern market realities. Our Clinical Development model brings the customer and the patient to the center of everything that we do. We are continuously looking for ways to simplify and streamline our work to not only make Syneos Health easier to work with, but to make us easier to work for.

Whether you join us in a Functional Service Provider partnership or a Full-Service environment, you'll collaborate with passionate problem solvers, innovating as a team to help our customers achieve their goals. We are agile and driven to accelerate the delivery of therapies, because we are passionate to change lives.

Discover what our 29,000 employees, across 110 countries already know:

WORK HERE MATTERS EVERYWHERE

Why Syneos Health

We are passionate about developing our people, through career development and progression; supportive and engaged line management; technical and therapeutic area training; peer recognition and total rewards program. We are committed to our Total Self culture - where you can authentically be yourself. Our Total Self culture is what unites us globally, and we are dedicated to taking care of our people. We are continuously building the company we all want to work for and our customers want to work with. Why? Because when we bring together diversity of thoughts, backgrounds, cultures, and perspectives - we're able to create a place where everyone feels like they belong.

Job Responsibilities

The Senior Project Manager, Clinical Operations - Full Service is responsible for providing customer-focused leadership in the management and delivery of the operational, financial, and strategic aspects of clinical research projects from proposal development through final deliverables. This role oversees studies ranging from single-service programs to large-scale, full-service global clinical trials across multiple phases and therapeutic areas. The Senior Project Manager serves as the primary client contact, leads cross-functional teams, and ensures projects are delivered on time, within budget, and in compliance with quality and regulatory standards.

This position requires a hands-on project manager who is actively involved in study execution and capable of independently leading complex clinical trials with minimal supervision.

Key Responsibilities

Project Leadership & Delivery

• Independently manage clinical studies from startup through closeout.
• Lead the operational and financial execution of Phase II and III clinical trials, including global and multi-protocol studies.
• Act as the primary liaison between sponsors and internal project teams.
• Ensure studies are conducted in accordance with GCP, ICH guidelines, regulatory requirements, and company SOPs.
• Oversee project timelines, budgets, resources, risks, and deliverables.
• Drive day-to-day study execution and proactively identify and resolve project issues.
• Coordinate activities across functional teams and external partners to ensure successful project delivery.
• Maintain accountability for project quality, financial performance, and customer satisfaction.

Client & Stakeholder Management

• Build and maintain strong relationships with sponsors and key stakeholders.
• Lead client meetings and provide regular project updates.
• Independently prepare and present project materials for internal and external meetings.
• Participate in bid defense meetings and business development activities as the designated Project Manager.
• Support client growth opportunities through exceptional project delivery and relationship management.

Financial & Operational Oversight

• Manage project budgets, forecasting, and financial performance.
• Monitor project progress through timelines, metrics, tracking tools, and reporting systems.
• Develop risk mitigation and contingency plans to ensure successful project outcomes.
• Ensure inspection readiness, including oversight of Trial Master Files and project documentation.
• Prepare project reports for sponsors and senior leadership.

Team Leadership & Mentoring

• Lead and motivate cross-functional project teams.
• Mentor and support junior Project Managers and Project Support staff.
• Facilitate project-specific and therapeutic area training as needed.
• Promote collaboration, communication, and accountability across teams.

Required Qualifications

• Minimum Bachelor's degree in Life Sciences, Medicine, Nursing, Pharmacy, or a related discipline, or equivalent combination of Bachelor's degree and experience.
• Clinical Research Organization (CRO) experience required.
• Proven experience independently managing clinical trials from initiation through closeout.
• Strong hands-on cross-functional project management experience with direct involvement in study execution.
• Experience independently managing project budgets, timel