Sr. Principal Software Engineer- Full Stack

Eli Lilly and Company; Indianapolis (IN); On-site; USD 140,000 - 180,000; Full time

Job summary

Lilly's Software Platform Engineering team is hiring a senior full-stack software engineer to build AI-powered platforms, developer tools, and enterprise applications in Indianapolis.

You will work across frontend and backend using React, Next.js, Node.js, Python, GraphQL and Neo4j, while containerizing with Docker and Kubernetes and deploying on AWS. The role emphasizes architecture, scalability, and collaboration with cross-functional teams.

Qualifications

• Bachelor's degree in Computer Science or related field.
• 5+ years of full-stack development experience with modern JavaScript/TypeScript frameworks.
• Experience with containerization, Kubernetes, databases, and AI-assisted development tools.

Responsibilities

• Build and deliver full-stack applications across diverse projects.
• Leverage React, Next.js, Node.js, Python, GraphQL, and Neo4j.
• Containerize apps with Docker and manage Kubernetes deployments.
• Contribute to system architecture, design and technical specifications.
• Collaborate with cross-functional teams to translate requirements into production-ready software.

Skills

JavaScript/TypeScript

Frontend development

Backend development

Kubernetes

Docker

Cloud platforms

AI-assisted tools

Graph databases

Education

Bachelor's degree in Computer Science

Master's degree (preferred)

Tools

Neo4j

GraphQL

Copilot

Claude Code

Job description

Role

Full-stack software engineer within Lilly's Software Platform Engineering organization, focusing on developing AI-powered platforms, developer tools, and enterprise applications.

Responsibilities

build and deliver full-stack applications across diverse projects, leveraging modern frameworks (React, Next.js, Node.js, Python, GraphQL, Neo4j), and integrate AI-assisted development tools to accelerate engineering processes. Operate as a generalist across frontend, backend, data engineering, and DevOps, including containerization (Docker, Kubernetes), CI/CD pipelines, and cloud deployment on AWS/EKS. Contribute to system architecture, design, and technical specifications, ensuring high-quality, scalable, and maintainable solutions. Collaborate with cross-functional teams and stakeholders to translate requirements into production-ready software. Maintain operational excellence through troubleshooting, monitoring, and managing cloud infrastructure.

Requirements

Bachelor's degree in Computer Science or related field; 5+ years of experience in full-stack development, with proficiency in modern JavaScript/TypeScript frameworks, backend languages (Python, Node.js), and cloud-native tools. Hands-on experience with containerization, Kubernetes, databases (relational, document, graph), and AI-assisted tools (Copilot, Claude Code). Preferred: Master's degree, 5-8+ years of experience, expertise in graph databases (Neo4j), GraphQL, AI/ML, and healthcare/biopharma industry knowledge. The role emphasizes fast-paced, ambiguous environments, with a focus on building innovative platforms to support Lilly's research and development efforts.