Sr. Principal Scientist, Cellular & Mechanistic Pharmacology

Johnson & Johnson; Lower Gwynedd Township (Montgomery County); On-site; USD 100,000 - 140,000; Full time

Job summary

An established industry player seeks a passionate scientist to lead innovative projects in cellular pharmacology. This role involves developing cutting-edge cell-based assays and collaborating with cross-functional teams to drive drug discovery from lab to life. With a focus on immunology and a commitment to addressing high unmet medical needs, this position offers an exciting opportunity to make a significant impact on healthcare solutions. Join a team where your expertise will contribute to groundbreaking advancements and help shape the future of medicine.

Qualifications

• Minimum of Ph.D. with post-doctoral experience and 10 years in cellular assays.
• Proven track record in managing drug discovery programs.

Responsibilities

• Lead development of innovative cell-based assays for drug discovery.
• Manage and mentor lab scientists and contribute to the pharmacology portfolio.

Skills

Immunology

Cellular Pharmacology

Assay Development

High-Throughput Technology

Data Analysis

Leadership

Problem Solving

Communication Skills

Education

Ph.D. in Immunology or Cell Biology

Tools

CAS/CRISPR

RNAi

Assay Automation

Job description

Sr. Principal Scientist, Cellular & Mechanistic Pharmacology

Join to apply for the Sr. Principal Scientist, Cellular & Mechanistic Pharmacology role at Johnson & Johnson

Sr. Principal Scientist, Cellular & Mechanistic Pharmacology

2 weeks ago Be among the first 25 applicants

Join to apply for the Sr. Principal Scientist, Cellular & Mechanistic Pharmacology role at Johnson & Johnson

At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, andsolutions are personal.Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.Learn more at https://www.jnj.com

Job Function

Discovery & Pre-Clinical/Clinical Development

Job Sub Function

Biological Research

Job Category

Scientific/Technology

All Job Posting Locations:

Spring House, Pennsylvania, United States of America

Job Description

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

We are searching for the best talent for Sr. Principal Scientist, Cellular & Mechanistic Pharmacology to be in Spring House, PA.

Purpose: The Discovery Technologies & Molecular Pharmacology (DTMP) team within Therapeutics Discovery contributes to the progression of drug discovery projects from target identification to clinical development. Join our team! We’re looking for a talented scientist with an immunology background, deep expertise in disease biology and cellular pharmacology, and a passion for finding innovative therapeutics to treat diseases with high unmet medical need.

Key Responsibilities

• Lead development of innovative cell-based assays for immunology-focused projects to identify and evaluate targets, and to progress hits and lead molecules.
• Act as a key liaison between DTMP and program teams, driving project strategy and execution, in partnership with cross-functional colleagues.
• Lead efforts to combine translational and mechanistic assays with biosignature approaches and novel AI/ML methods to reveal new biology and pharmacology.
• Manage and mentor lab scientists and contribute to the cellular and mechanistic pharmacology portfolio.
• Analyze and present data at program team meetings, in-house seminars, leadership meetings and external scientific conferences, and publish research in high-quality journals.
  
  

Qualifications

Education:

• Minimum of Ph. D. in Immunology, cell biology or equivalent with post-doctoral experience and a minimum of 10 years of experience developing and applying novel cellular assays in a pharmaceutical industry/biotech setting, is required.
  
  

Experience And Skills

Required:

• Proven track record in managing immunology-focused drug discovery programs across diverse modalities, in an industry setting.
• Deep expertise and proven accomplishments in de novo immunology cellular pharmacology assay development, complex immune cellular models and high-throughput technology platforms.
• Experience with generating and culturing translationally relevant cell models such as iPSC-derived cells, primary cells, and/or co-cultures.
• Expertise collecting and analyzing data using high dimensional approaches such as high content imaging, flow cytometry and/or RNAseq.
• Strong experience as a leader, problem solver and team collaborator able to facilitate understanding between biologists, chemists, and data scientists.
• A demonstrated ability to apply novel approaches to address complex biology questions, as evidenced through strong peer-reviewed publications.
• Excellent written communication, verbal communication, and oral presentation skills.
• Demonstrated influence, negotiation, and conflict resolution skills.
  
  

Preferred

• Expertise in assay automation.
• Proficiency with CAS/CRISPR, lentivirus and/or RNAi approaches.
• Expertise developing assays in advanced 3D cell models.
• Expertise in neuroscience and/or oncology therapeutic areas.
• Experience working with and/or guiding external collaborators in industry or academia.
  
  

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson and Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, please email the Employee Health Support Center ([e-mail]) or contact AskGS to be directed to your accommodation resource

Seniority level

• Seniority level

  Not Applicable

Employment type

• Employment type

  Full-time

Job function

• Job function

  Research, Analyst, and Information Technology

• Industries

  Hospitals and Health Care

Referrals increase your chances of interviewing at Johnson & Johnson by 2x

Get notified about new Senior Principal Scientist jobs in Spring House, PA.

Senior Scientist/Principal Scientist, Analytical Sciences & Operations

Sr Scientist, Extractables and Leachables

Senior Principal Scientist, Automation Engineer

Senior Scientist/Principal Scientist, Analytical Sciences & Operations

Philadelphia, PA $100,000.00-$140,000.00 3 months ago

Principal Scientist - (Director) - Outcomes Research

Principal Scientist, Clinical Pharmacology

Principal Scientist, Clinical Pharmacology

Scientist/Sr. Scientist Pharmaceutical Analysis-Small Molecule

Senior Principal Scientist, Bioanalytics

Senior Principal Scientist, Computational Multiomics, Precision Measures

Principal Scientist/Group Leader - Granules

Senior Scientist, Single-Cell Foundation Models (M/F/D)

Senior Scientist, Viral Vector Drug Product Formulation

Senior Scientist, Scientific Outsourcing

Principal Scientist, Lentivirus Upstream Process

Senior Principal Scientist, Technology Innovation, Commercial Data Science

We’re unlocking community knowledge in a new way. Experts add insights directly into each article, started with the help of AI.