Sr. Principal Process Engineer –Packaging

Biopharma Careers; Wilson (NC); On-site; USD 180,000 - 240,000; Full time

Job summary

Johnson & Johnson in Wilson, North Carolina, seeks a Sr. Principal Process Engineer – Packaging to own end-to-end packaging equipment engineering for large-molecule biotherapeutic drug products.

You will lead specifications, design documents, FAT/SAT, commissioning, and C&Q activities while collaborating with multi-functional teams to ensure regulatory compliance and on-time startup of commercial lines. The role requires 10+ years of packaging engineering experience, strong leadership, and a

Qualifications

• Bachelor's degree in engineering required; mechanical preferred.
• 10+ years of packaging equipment process engineering and capital projects.
• Experience with large-molecule biotherapeutics and aseptic packaging.
• Serialization and aggregation knowledge; cGMP awareness.

Responsibilities

• Lead development and delivery of packaging specifications, drawings, P&IDs, and PFDs.
• Own packaging equipment process engineering across full product lifecycle.
• Lead FAT, SAT, commissioning, and C&Q for packaging lines.
• Collaborate with multi-functional teams and external partners.

Skills

Packaging equipment process eng

Capital project execution

Cross-functional leadership

Aseptic packaging knowledge

Education

Bachelor's Degree in Engineering

MS or MBA preferred

Job description

Johnson & JohnsonPosted September 10, 2026# Sr. Principal Process Engineer –PackagingWilson, United States Full timeManufacturing & CMC PrincipalNotify me about similar jobsView Full Job & Apply at Johnson & JohnsonJohnson & Johnson is the source of truth for this posting and owns the application process. We surface normalized context and market comparison you won't find on the original listing.## About this opportunityAt Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com .As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.**Job Function:**Supply Chain Engineering**Job Sub Function:**Process Engineering**Job Category:**Scientific/Technology**All Job Posting Locations:**Wilson, North Carolina, United States of America**Job Description:****About Innovative Medicine**Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.Learn more at https://www.jnj.com/innovative-medicineLearn more and apply to this exciting new role!As part of the Global Process Engineering team, the Sr. Principal Process Engineer – Packaging serves as the recognized technical authority and domain expert for packaging equipment. This role is accountable for end-to-end (E2E) process engineering ownership of packaging equipment, from conceptual design, commissioning and qualification, through initial equipment start-up for commercial manufacturing.**Key Responsibilities:**Leads development and delivery of packaging specifications and drawings (user requirements, data sheets, technical specifications, P&IDs, PFDs) supporting large-molecule, aseptic biotherapeutic drug product operationsProvide process system ownership and technical leadership for packaging equipment used in biotherapeutic drug product manufacturingAssess vendor competency and capabilities, review and influence bid documents, and maintain accountability for project development and execution, including system performanceLead detailed design and development of packaging equipment for biotherapeutic drug products, collaborating with multi-functional partners and strategic equipment vendorsServe as the Packaging Equipment SME for large-molecule, aseptic drug product projects, collaborating with A&E firms, construction partners, and equipment suppliersLead and support equipment FAT, SAT, commissioning, qualification, and commercial production line start-up activitiesResolve complex technical issues during C&Q and ensure system readiness for qualification and commercial operationPartner closely with Manufacturing, Facilities, MSAT, Quality, Procurement, E&PS, and EHS to align priorities and accelerate executionEnsure alignment across evolving business needs, applying strong collaborator and partner leadership skillsMaintain current knowledge of industry trends, aseptic processing techniques, and biotherapeutic regulatory expectationsApply data-driven insights and market intelligence to guide technical and strategic decisionsEnsure full compliance with company policies, cGMPs, regulatory requirements, and customer specifications**Qualifications****Education:**A minimum Bachelor's Degree in engineering required (Mechanical Engineering preferred)MS or MBA preferred**Experience and Skills:****Required:**A minimum of 10 years packaging equipment process engineering and/or capital project execution experience within a large-molecule, biotherapeutic and synthetics environmentStrong background in large-molecule, biotherapeutic drug product device packaging equipment principlesExperience leading packaging equipment process engineering activities across the full product lifecycle, preferably within capital project executionShown ability to build and maintain strong partnerships with multi-functional customersAbility to lead and influence multicultural teams and remote collaboratorsExtensive interaction with external partners (A&E firms, construction teams, and equipment vendors) as Packaging Equipment SMEDemonstrated strength in resolving complex technical and regulatory challenges impacting the equipment and facility design of packaging equipment for large-molecule, biotherapeutic productsSignificant experience with implementing serialization and aggregation for the packaging of large-molecule, biotherapeutic products**Solid understanding of the following:**cGMP requirements for biotherapeutic, large-molecule packaging equipmentSerialization and aggregation processes for finished biotherapeutic drug productsEHS requirements, with emphasis on EHS-by-design and construction safetyStart-up processes and Commissioning & Qualification (C&Q) of aseptic equipmentEngineering design principles for biotherapeutic drug product manufacturingConstruction, procurement, project controls, and project schedulingStrong technical depth, problem-solving capability, interpersonal skills, and decision-making ability in a fast-paced environmentPassion for driving innovation in aseptic equipment and facility design**Preferred:**Demonstrated leadership of capital projects for aseptic large-molecule, biotherapeutic packaging equipment in the $50-$100 MM rangeDeep process engineering expertise from conceptual design through C&Q to operational readiness in large-molecule biotherapeutic drug product environmentsExperience supporting greenfield or brownfield GMP aseptic manufacturing facility start-ups for packaging equipmentExperience with combination products and associated regulatory expectationsExperience with automated case packers and automated palletizers**Other:**This position will be located in **Wilson, North Carolina,** and will require full time on-site support. However, the design of the facility will occur at an Engineering firm with frequent travel (> 75%) required until the project shifts to the plant site of Wilson, NC.For more information on how we support the whole health of our employees throughout their wellness, career and life journey, please visit www.careers.jnj.com .]Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, external applicants please contact us via https://www.jnj.com/contact-us/careers , internal employees contact AskGS to be directed to your accommodation resource.