Sr PI, Physical AI for Autonomous Discovery

6084-Janssen Research & Development, LLC Legal Entity; Spring House (PA); On-site; USD 137,000 - 236,000; Full time

Benefits offered by this job

Annual bonus

Job summary

Johnson & Johnson Innovative Medicine is recruiting for a Senior Principal Investigator, Physical AI for Autonomous Discovery to join our In Silico Drug Discovery team. The preferred location is Spring House, PA, with occasional travel; Cambridge, MA candidates considered.

Lead hands-on AI for autonomous lab discovery, integrating AI, robotics, and scientific reasoning. You will design, implement, and validate systems that perceive laboratory state, learn from data, recover from errors, and

Qualifications

• PhD in artificial intelligence, machine learning, robotics, computer science, engineering, computational biology, or a related quantitative field, with substantial relevant research or industry experience.

Responsibilities

• Lead the hands-on design, development, and validation of AI models that represent instruments, samples, reagents, robotic systems, workflows, and laboratory state.
• Develop and evaluate adaptive experimental optimization methods using active learning, Bayesian optimization, reinforcement learning, and multi-objective optimization.
• Implement capabilities for physical error detection and correction, including anomaly recognition, root-cause assessment, workflow replanning, recovery actions, and appropriate human escalation.
• Build models that generate testable hypotheses for experimental failures, unexpected results, variability, and irreproducibility, and recommend discriminating follow-up experiments.
• Develop agentic and multi-agent capabilities that support experiment planning and execution monitoring across Design-Make-Test-Analyze cycles.

Skills

Physical AI & World Models

Autonomous Experimentation

Error Intelligence

Robotics & Automation

Agentic AI

Scientific Software

Python

APIs

MLOps

Education

PhD in AI/ML/Robotics or related

Tools

Python

ML frameworks

APIs

Data pipelines

MLOps

Job description

Johnson & Johnson Innovative Medicine is recruiting for a Senior Principal Investigator, Physical AI for Autonomous Discovery to join our In Silico Drug Discovery team. The preferred location is Spring House, PA, with occasional travel; Cambridge, MA candidates considered.

Lead hands-on AI for autonomous lab discovery, integrating AI, robotics, and scientific reasoning. You will design, implement, and validate systems that perceive laboratory state, learn from data, recover from errors, and