Sr Infrastructure Engineer

Baylor Genetics; Houston (TX); On-site; USD 120,000 - 160,000; Full time

Job summary

Baylor Genetics in Houston seeks a Senior Infrastructure Engineer to serve as backup for the on‑premises data center, ensuring uninterrupted operation of critical systems across genomics pipelines and clinical labs.

You will maintain servers, storage, and networks (Windows Server, Linux, VMware/Hyper‑V), manage data center operations, and develop runbooks and disaster‑recovery docs to eliminate single points of failure while supporting patient‑impacting workflows.

Qualifications

• Bachelor’s degree in IT, CS, or equivalent experience.
• 7+ years of hands-on enterprise IT infrastructure engineering in on-premises environments.
• Deep server administration across Windows Server and Linux with VMware/Hyper‑V.
• Strong networking, including routing, switching, VLANs, and firewall management.
• Experience managing data center racks, cabling, power, and cooling.
• Proficiency with SAN/NAS storage and backup systems (Veeam/Commvault).
• Knowledge of Microsoft 365 and Azure AD in hybrid contexts.
• Excellent runbook and SOP documentation; independent problem solving.

Responsibilities

• Act as backup for primary infrastructure lead to ensure zero service interruption.
• Administer and maintain data center servers, storage, and network infrastructure.
• Manage LAN/WAN, switches, routers, firewalls, and VLANs for high availability.
• Create and maintain runbooks, diagrams, and disaster recovery docs.
• Support genomics pipeline infrastructure with required throughput and availability.
• Collaborate with bioinformatics, clinical lab, and IT teams.
• Identify and remediate risks, including aging hardware and config vulnerabilities.
• Respond to incidents, including after-hours escalations.
• Perform other duties as assigned.
• Comply with policies, procedures, and regulatory requirements.

Skills

IT infrastructure engineering

Windows Server

Linux

VMware vSphere

Hyper-V

Networking

Data center operations

SAN/NAS storage

Veeam/Commvault backups

Microsoft 365

Azure AD

Education

Bachelor’s degree in IT/CS or related field

Equivalent experience

Tools

VMware vSphere

Microsoft Hyper-V

Veeam

Commvault

Cisco networking

Palo Alto / Fortinet firewalls

Microsoft 365

Azure AD

Job description

The Senior Infrastructure Engineer serves as the designated backup and knowledge‑continuity resource for Baylor Genetics’ on‑premises data center and network environment. This role exists to ensure uninterrupted operation of the critical infrastructure supporting our genomics pipeline and clinical laboratory systems, and to eliminate single points of failure in IT operations. This role may evolve as organizational needs change.

• Exists to sustain, document, and be fully capable of independently operating all core on‑premises infrastructure — servers, storage, networking, and security systems — in any operational scenario, including emergency coverage of the primary infrastructure lead.
• Impacts clinical laboratory operations, genomics pipeline throughput, and the reliability of all on‑premises and hybrid‑connected systems used across the organization.
• Success looks like: zero unplanned outages attributable to single‑person dependency, a fully documented environment with up‑to‑date runbooks, and the demonstrated ability to assume full infrastructure ownership without disruption.

Key Responsibilities

• Serve as the designated backup for the primary infrastructure lead — assume full operational control of data center, network, and server environments during absences, emergencies, or transitions to ensure zero service interruption.
• Administer and maintain physical and virtual server infrastructure (Windows Server, Linux, VMware/Hyper‑V), including provisioning, patching, performance monitoring, and capacity planning to sustain 99.9%+ uptime.
• Manage LAN/WAN networking operations including switches, routers, firewalls, and VLANs to maintain high availability and security across all on‑premises systems.
• Build, maintain, and continuously improve runbooks, network diagrams, and disaster recovery documentation to eliminate single points of failure and reduce mean time to recovery.
• Support and sustain the on‑premises genomics pipeline infrastructure, ensuring compute and storage resources meet demanding throughput and availability requirements for clinical laboratory operations.
• Collaborate cross‑functionally with bioinformatics, clinical lab, and IT teams to align infrastructure reliability with patient‑impacting laboratory workflows.
• Proactively identify and remediate risks including aging hardware, technical debt, and configuration vulnerabilities — presenting actionable proposals to leadership.
• Respond to infrastructure incidents and outages with urgency, including after‑hours escalations, to minimize downtime impact on laboratory and clinical operations.
• Perform other duties as assigned to support team and organizational objectives.
• Comply with all company policies, procedures, and applicable regulatory requirements.

Qualifications

Required

• Bachelor’s degree in Information Technology, Computer Science, or a related field; or equivalent technical training and experience.
• 7+ years of hands‑on enterprise IT infrastructure engineering experience in a complex, predominantly on‑premises environment.
• Deep expertise in physical and virtual server administration (Windows Server 2016/2019/2022, Linux) including VMware vSphere or Microsoft Hyper‑V.
• Strong networking fundamentals: routing, switching, VLANs, firewall policy management, and systematic network troubleshooting (Cisco, Palo Alto, Fortinet, or equivalent).
• Experience managing physical data center environments — rack/stack, structured cabling, power, and cooling awareness.
• Proficiency with SAN/NAS storage platforms and enterprise backup/recovery systems (Veeam, Commvault, or equivalent).
• Working knowledge of Microsoft 365 and Azure Active Directory in a hybrid on‑premises/cloud context.
• Strong documentation discipline: ability to produce clear runbooks, network diagrams, and standard operating procedures independently.
• Proven ability to rapidly learn complex, undocumented environments and operate independently under high‑pressure conditions.
• Equivalent combination of education and experience may be considered.

Preferred

• Experience in a healthcare, clinical laboratory, genomics, or other regulated life sciences environment.
• 7+ years of progressive experience in enterprise infrastructure roles with demonstrated ownership of critical systems.
• Relevant certifications: CCNA/CCNP, VCP‑DCV, MCSE, CompTIA Network+/Security+, or equivalent.
• Familiarity with HPC or high‑throughput bioinformatics pipeline infrastructure.
• Exposure to HIPAA compliance requirements, NIST frameworks, or SOC 2 audit environments.