Sr Dir Preclinical & Translational PK/PD

Regeneron Pharmaceuticals, Inc; Village of Tarrytown (NY); On-site; USD 300,000 - 450,000; Full time

Job summary

Regeneron Pharmaceuticals, Inc. seeks a Senior Director of Preclinical & Translational PK/PD to lead PK/PD strategy across discovery programs through IND/CTA.

You will guide PK/PD study design, coordinate with Therapeutic Proteins, Assay Development, and Clinical Pharmacology, and influence decision-making at multiple levels. The role demands a seasoned scientist with a proven track record in PK/PD and the ability to translate data into actionable program plans while driving collaboration across

Qualifications

• Seasoned scientist with extensive PK/PD knowledge.
• Experience leading cross-functional discovery programs.
• Ability to translate PK/PD data into strategic program decisions.

Responsibilities

• Serves as SME for Preclinical and Translational PK/PD on Discovery-stage project teams.
• Collaborates with Therapeutic Proteins, Assay Development, and Clinical Pharmacology to develop PK/PD strategies.
• Oversees nonclinical PK/PK-PD studies and reports analyses from preclinical data.
• Presents PK/PD findings to project teams, TPK/PD, and senior management.
• Derives FIH dose predictions in collaboration with Clinical Pharmacology.
• Works closely with Toxicology and Pathology teams to support program goals.

Skills

PK/PD expertise

Leadership

Strategic planning

Cross-functional collaboration

Job description

Senior Director, Preclinical & Translational PK/PD

At Regeneron, we use science and innovation to develop life-changing medicines for people with serious diseases. We are seeking a Senior Director to support PK and PK/PD requirements for early-stage drug discovery through IND/CTA projects. You'll utilize a mastery level of PK/PD knowledge and strategic leadership skills to effectively develop and implement strategic analyses supporting research and development projects. You'll exert influence across the organization at multiple levels, including individual contributors (in and out of the function), development program teams, and other functional managers, and will be accountable for the PK/PD evaluation of a portfolio of projects and/or highly complex programs/platforms that can be wide in scope.

This role is suited for individuals who thrive in a fast-paced, collaborative environment, are passionate about science and motivated to contribute to bringing new drugs to patients, and desire exposure to multiple therapeutic areas and emerging modalities. We're looking for seasoned and tenured scientists with a demonstrated ability to provide significant impact on the organization and external groups, readily able to influence and effect change.

This position offers the opportunity to contribute to a fast-growing, science-driven organization making a meaningful difference to patients worldwide.

When & where:

Discover your role:

• Serves as a subject matter expert regarding Preclinical and Translational PK/PD on Discovery-stage project teams, guiding the design of preclinical pharmacology, PK, and PK/PD studies
• Collaborates with various internal groups such as Therapeutic Proteins, Therapeutic Function Areas, Assay Development, Precision Medicine, Preclinical Operations, and TPK/PD management to develop and execute PK/PD strategies for projects
• Provides input and oversight for preclinical in vivo studies, coordinating with scientific teams conducting these studies
• Manages nonclinical PK and PK/PD studies, and conducts and reports PK/PD analyses based on data from preclinical studies
• Analyzes and presents PK and PK/PD data to project teams, TPK/PD, and senior management
• Derives first in human (FIH) dose predictions in collaboration with Clinical Pharmacology
• Works closely with Toxicology, Pathology, Clinical Pharmacology,