Sr. Biologist - Molecular Pharmacology

Initial Therapeutics, Inc.; Indianapolis (IN); On-site; USD 76,000 - 163,000; Full time

Job summary

An innovative healthcare leader in Indianapolis is seeking a skilled biologist to join their Molecular Pharmacology team. In this dynamic role, you'll leverage your expertise in cell engineering and assay development to drive drug discovery efforts. You'll design cell lines, develop cutting-edge assays, and perform high-throughput screenings to characterize novel therapeutics. This position offers an exciting opportunity to work in a collaborative environment, where your contributions will directly impact the discovery of life-changing medicines. If you're passionate about science and eager to make a difference, this role is for you!

Qualifications

• Expertise in cell engineering and assay development is essential.
• Hands-on experience with CRISPR and GPCRs is preferred.

Responsibilities

• Design and create cell lines for GPCR pharmacology.
• Develop cell-based assays and perform high-throughput screening.
• Collaborate with partners to ensure quality results.

Skills

Cell Engineering

Assay Development

High Throughput Screening

Data Interpretation

Collaboration

Safety Culture

Communication Skills

Education

MS in Biology

BS in Biology with lab experience

Tools

Liquid Handling Robots

Assay Automation

Job description

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Compensation:
Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $76,500 - $162,800.

Organization Overview:
The Discovery Chemistry Research & Technologies organization (DCR&T) within Lilly Research Laboratories (LRL) is seeking a highly skilled and motivated biologist with expertise in cell engineering and assay development to join our Molecular Pharmacology team at Lilly Corporate Center, Indianapolis, Indiana. The successful candidate will be part of a highly integrated, agile, and collaborative team, encompassing Biophysics, Bioanalytical, Chemical Biology to bring innovative Molecular Pharmacology approaches to accelerate the drug discovery pipeline. In this position, the candidate will assist in cell line generation, assay development, and high throughput screening to identify and characterize the in vitro pharmacology of novel therapeutics, playing a crucial role in supporting our comprehensive drug discovery efforts.

Responsibilities:

• Independently design and create cell lines suitable for characterizing GPCR pharmacology and improve success rates in Hit finding.
• Use cutting-edge technologies to develop cell-based assays to understand target engagement and signaling pathways.
• Perform high-throughput cell-based assays using multiple platforms (e.g. imaging, reporter gene, immunoassay, gene expression assays).
• Interpret experimental data, along with observations from the literature, to introduce creative solutions to project teams.
• Provide data and insights into the pharmacology of small molecules to support drug discovery projects in multiple therapeutic areas (diabetes, immunology, and neurosciences).
• Work in close collaboration with internal/external partners to ensure a strong relationship and rapid delivery of quality results in a format customized to meet their specific needs.
• Strive to maintain a proactive safety culture with always keeping safety as the top priority.

Basic Requirements:

• MS in biology, molecular biology, biochemistry, or closely related field; or,
• BS in biology, molecular biology, biochemistry, or closely related field with a minimum of 2 years relevant lab experience.

Additional Skills/Preferences:

• Hands-on cell culture experience working with multiple cell lines (e.g. HEK293, THP-1, primary cell lines, and/or other).
• Prior work with CRISPR gene editing, cell sorting, and/or stable cell line generation.
• Previous work with GPCRs and related cell signaling mechanisms.
• Experience with cell-based assay development and high-throughput screening.
• Proficient in operating liquid handling robots and in assay automation.
• Experience with instrument maintenance and large-scale data management.
• Demonstrated initiative and appropriate risk-taking with the proven ability to prioritize and manage multiple activities.
• Enthusiastic and self-motivated, with excellent communication skills necessary to operate effectively in a fast-paced, multidisciplinary environment. Demonstrated flexible and adaptable approach to ensure project success.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

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