Sr. Bioinformatics Software Engineer

Mithrl; San Francisco (CA); On-site; USD 130,000 - 238,000; Full time

Job summary

Mithrl is seeking a Senior Bioinformatician to shape an AI platform that interprets complex genomics. You will own bioinformatics processes, collaborate with cross-functional teams, and provide insights that influence drug discovery decisions. Ideal candidates will have strong experience in bioinformatics, Python, and machine learning, and thrive in a fast-paced tech-bio environment.

Benefits

Comprehensive PPO health coverage

401(k) with top-tier plans

Qualifications

• 5-10 years of experience in bioinformatics.
• Deep fluency in Python and SQL working with structured genomics data.
• Strong grasp of statistical and machine learning methods for biological data.

Responsibilities

• Own the full bioinformatics stack from data ingestion to insight generation.
• Collaborate with product and AI teams to ensure biological impact.
• Mentor junior scientists and ensure scientific accuracy.

Skills

Python

SQL

Statistical methods

Machine learning

Genomics tools

Job description

Application Link: Apply here: https://jobs.ashbyhq.com/mithrl/ff97f007-201e-46a3-b39d-c25c886564e2

Note: Applications submitted via LinkedIn will not be reviewed. Please apply through our official job board.

About Mithrl

We envision a world where novel drugs and therapies reach patients in months, not years, accelerating breakthroughs that save lives.

Mithrl is building the world’s first commercially available AI Co-Scientist—a discovery engine that empowers life science teams to go from messy biological data to novel insights in minutes. Scientists ask questions in natural language, and Mithrl answers with real analysis, novel targets, and patent-ready reports. No coding. No waiting. No bioinformatics bottlenecks.

We are the fastest growing tech-bio startup in the Bay Area with over 12X YoY revenue growth. Our platform is already being used by teams at some of the largest biotechs and big pharma across three continents to accelerate and uncover breakthroughs—from target discovery to mechanism of action.

Why This Role Matters

We’re not just running pipelines. We’re building systems that think like scientists. As a Senior Bioinformatician at Mithrl, you’ll play a critical role in shaping how our AI platform understands and interprets complex genomics data—across bulk RNA-seq, single-cell, CRISPR, and beyond.

You won’t just run tools, you’ll know how they work. You’ll help us design smarter algorithms, build analysis frameworks that generalize, and uncover insights that matter to drug discovery teams around the world. You’ll work closely with our AI scientists, software engineers, and customer partners to bridge data, computation, and biology in real time.

What You’ll Do

• Ownership: Own the full bioinformatics stack -- from ingesting raw data to generating insights that drive real-world drug program decisions. Your work will be the scientific backbone of Mithrl’s AI.
• Work closely with our product, AI, and customer teams to make sure your work is not just technically correct, but biologically meaningful and decision-driving
• Go beyond pipelines: Understand what tools are doing, why results look the way they do, and how to improve them
• Collaborate with engineers and product teams to turn bioinformatics insights into scalable software features
• Validate findings, spot inconsistencies, and suggest new hypotheses for customers and internal use
• Translate messy biological questions into clean computational problems, and vice versa
• Mentor junior scientists and review technical outputs to ensure scientific accuracy
• Stay up-to-date on the latest methods in transcriptomics, functional genomics, and statistical analysis

What We’re Looking For

• 5–10 years of experience in bioinformatics
• Deep fluency in Python and SQL, including experience working directly with structured genomics data at scale
• Strong grasp of statistical and machine learning methods applied to high-throughput biological data
• Hands-on experience with modern genomics tools and file formats (e.g., GWAS, aligners, etc.)
• Ability to interpret and debug pipeline results; not just run them
• Strong scientific judgment, clarity in communication, and attention to detail
• **Curiosity, persistence, and a drive to understand how things work
• **High energy, strong work ethic, and a track record of getting things done
• **Discipline Wins: At Mithrl, the social currency is hard work and consistency. The problems we’re solving are complex and take time to bear fruit. We value teammates who show up every day, work with focus, and bring long-term discipline to their craft
• Bonus: Experience working with AI/ML scientists or integrating bioinformatics with production software

What You’ll Love

• Scope: Shape how a cutting-edge AI platform thinks about biology and delivers real insight
• Impact: Your work will directly influence drug discovery decisions at top biotech companies
• Team: Join a world-class crew of AI scientists, engineers, and biologists working together at full speed
• Culture: No ego, no bureaucracy. Just deep thinking, fast execution, and high ownership
• Location: Beautiful SF office with a focus on in-person, high-bandwidth collaboration
• Benefits: Comprehensive PPO health coverage through Anthem (medical, dental, and vision) + 401(k) with top-tier plans

How to Apply

Send us a note with your resume or portfolio of work, and a few words about why you’re excited about Mithrl.

Application tip: Hidden in Middle-earth, in the depths of Khazad-dûm, lies a name not easily forgotten. In your application, please include the answer to this question: What was the name of the Balrog that Gandalf fought in Moria?

Seniority level

• Seniority level

  Mid-Senior level

Employment type

• Employment type

  Full-time

• Industries

  Software Development

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