Sr. Associate Scientist, Downstream Process

Legend Biotech; Philadelphia (Philadelphia County); On-site; USD 81,000 - 112,000; Full time

Job summary

A global biotechnology company is seeking a Sr. Associate Scientist for their Downstream Process team in Philadelphia. This position involves manufacturing lentiviral vectors and performing purification processes at both preclinical and industrial scales while collaborating with research teams to optimize production capabilities.

Benefits

Health Insurance

Dental Insurance

Vision Insurance

Matched 401K

Flexible Spending Account

Health Savings Account

Paid Maternity Leave

Paid Paternity Leave

Commuter Benefits

Employee Assistance Program

Qualifications

• BS degree with 3+ years or MS degree with 2+ years industry experience.
• Experience in lentiviral vector production required.
• Proficiency with DSP equipment and ability to support process optimization.

Responsibilities

• Manufacture lentiviral vector using suspension cell lines.
• Perform downstream purification and optimization of DSP.
• Collaborate with upstream teams and conduct experimental analysis.

Skills

Hands-on experience in lentiviral vector production

Proficiency with DSP equipment

Ability to thrive in a fast-paced biotech environment

Education

BS degree

MS degree

Tools

HPLC/FPLC (e.g. AKTA)

TFF (e.g. KrosFlo)

Job description

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide.

Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.

Legend Biotech is seeking a Sr. Associate Scientist/ Associate Scientist- Downstream Process as part of the Vector Biology team based in Philadelphia, PA.

Role Overview

This role involves manufacturing lentiviral vectors using suspension cell cultures and performing downstream purification at both preclinical and industrial scales, including cell clarification, chromatography, TFF/diafiltration, and sterile filtration. The position supports internal research teams, contributes to process optimization and technology transfer, and collaborates closely with upstream and analytical groups.

Key Responsibilities

• Manufacture lentiviral vector (LVV) using suspension cell lines in shake flasks
• Perform downstream purification with preclinical and industrial scales
• Test downstream processes (DSP), optimize, and help to lock-in final DSP starting from cell clarification, column chromatography, TFF/diafliltration, and sterile filtration
• Perform manual fill/finish operations for final LVV products
• Support LVV production for internal research teams
• Independently plan, conduct, analyze, and report experimental data, contributing to future technology transfer activities
• Collaborate closely with the upstream process team and LVV analytical team
  
  
  

Requirements

• BS degree with 3+ years of industry experience; MS degree with 2+ years industry experience
• Hands-on experience in lentiviral vector production
• Proficiency with DSP equipment such as HPLC/FPLC (e.g. AKTA) and TFF (e.g. KrosFlo) systems
• Ability to thrive in a fast-paced biotech environment and effectively prioritize workload
  
  
  

The anticipated base pay range for this is: $81,273 - $111,750 USD.

Benefits:

We are committed to creating a workplace where employees can thrive - both professionally and personally. To attract and retain top talent in a highly competitive industry, we offer a best-in-class benefits package that supports well-being, financial stability, and long-term career growth. Our offerings are designed to meet the diverse needs of our team members and their families, ensuring they feel valued and supported every step of the way. Highlights include medical, dental, and vision insurance as well as a 401(k)-retirement plan with company match that vest fully on day one. Equity and stock options are available to employees in eligible roles, we offer eight weeks of paid parental leave after just three months of employment, and a paid time off policy that includes 15 vacation days, 5 personal days, 5 sick days, 11 U.S. national holidays, and 3 floating holidays. Additional benefits include flexible spending and health savings accounts, life and AD&D insurance, short- and long-term disability coverage, legal assistance, and supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance. We also provide commuter benefits, family planning and care resources, well-being initiatives, and peer-to-peer recognition programs - demonstrating our ongoing commitment to building a culture where our people feel empowered, supported, and inspired to do their best work.

EEO Statement

Legend Biotech is a proud equal opportunity/affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is Legend’s policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic/civil partnership status, genetic information, citizenship status, uniformed service member or veteran status, or any other characteristic protected by applicable law.

Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company. Legend may adjust base salary or other discretionary compensation at any time based on individual, team, performance, or market conditions.

Legend Biotech maintains a drug-free workplace.

Benefits:

• Health Insurance
• Dental Insurance
• Vision Insurance
• Life Insurance
• Matched 401K
• Flexible Spending Account
• Health Savings Account
• AD&D Insurance
• Short-Term Disability
• Long-Term Disability
• Paid Maternity Leave
• Paid Paternity Leave
• Pet Insurance
• Critical Illness Insurance
• Hospital Indemnity Insurance
• Accident Insurance
• Legal Insurance
• Commuter Benefits
• Employee Assistance Program

Seniority level

• Seniority level

  Mid-Senior level

Employment type

• Employment type

  Full-time

Job function

• Job function

  Research, Analyst, and Information Technology

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