Sr Associate Scientist - Conjugation Chemistry

Pfizer Inc; New York (NY); On-site; USD 68,000 - 114,000; Full time

Benefits offered by this job

401(k) plan with Pfizer Matching Pro

Pfizer Retirement Savings Contribution

Paid vacation

Holiday and personal days

Paid caregiver/parental and medicalle

Health benefits

Job summary

Pfizer's Early Bioprocess Development team within Vaccine Research and Development seeks a Senior Associate Scientist to advance conjugation process development for glycoconjugate vaccines. You will support development, optimization, and scale-up, analyze intermediates and glycoconjugates, and document results in compliant electronic notebooks.

You will collaborate across fermentation, purification, analytical and formulation groups, contribute to technology transfer, and present data while

Qualifications

• BS degree with 3–6 years lab experience or MS degree with 0–4 years experience.
• Strong background in organic chemistry is required.
• Experience operating instruments and executing analytical methods; electronic notebook documentation.

Responsibilities

• Support the development, optimization and scale-up of glycoconjugate vaccine process development.
• In-process analysis of glycoconjugates and intermediates.
• Evaluate processes for robustness, propose improvements to senior team members.
• Collaborate with fermentation, purification, analytical and formulation development groups.
• Support technology transfer to clinical manufacturing sites and provide technical support.
• Document laboratory experiments in electronic notebooks and prepare technical reports.
• Perform other duties as assigned.

Skills

Strong communication

Laboratory data analysis

Documentation

Independent data interpretation

Education

BS in Chemistry/Biochemistry

MS in Chemistry/Organic Chemistry

Tools

HPLC

MALS

UV-Vis

NMR

Job description

Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best-in-class medicines to patients around the world.

Role Summary

As a Senior Associate Scientist in the Early Bioprocess Development within Pfizer Vaccine Research and Development, you will be at the center of our operations and you'll find that everything we do, every day, is in line with an unwavering commitment to quality. You will join a large team of Scientists focused on conjugation process development for manufacturing carbohydrate-based conjugate vaccines. Primary duties include supporting the development and optimization of conjugation methods, purification, and analysis of intermediates and glycoconjugates using chemical and chromatographic methods. The individual will become a key contributor towards supporting the early development and scale up of glycoconjugate vaccines. Careful documentation of work and presentation of data is required. All work is to be done in a compliant manner according to SOP guidelines and cGMP/GLP regulations, where applicable.

Role Responsibilities

• Support the development, optimization and scale-up of glycoconjugate vaccine process development.
• In process analysis of glycoconjugates and intermediates.
• Continuously evaluate each process and technique to determine if it is robust, appropriate, and scalable. If an operation has shortcomings or can be improved, propose solution in discussion with other group members to advance objectives.
• Collaborate with colleagues within Vaccine Research and Development organization including Early Bioprocess fermentation, purification, analytical and formulation development groups.
• Participate in the technology transfer of developed process to clinical manufacturing site, both internally and externally, and provide the technical support as needed.
• Fully document laboratory experiments in electronic notebook in a timely and compliant manner and prepare technical reports as needed.
• Perform other duties as assigned.

Qualifications

Must have

• BS degree in Chemistry/Biochemistry or related discipline with 3 to 6 years laboratory experience or MS degree in Chemistry/Organic Chemistry or related discipline with 0 to 4 years of experience.
• Strong background in organic chemistry is required.
• Knowledge and ability to operate and maintain relevant instruments, resolve technical problems related to instruments, and execution of analytical methods.
• Independently analyze and provide conclusions regarding experimental data generated.
• Strong verbal and written communication skills are required.
• Experience with documentation of laboratory notebook in an electronic format.

Nice To Have

• Experience in carbohydrate chemistry
• Hands on experience with various analytical techniques such as HPLC, MALS, UV-Vis, NMR, and other routine lab instruments.
• Proficiency with personal computers including word processing, spreadsheets, PowerPoint, and relevant scientific software

Other Work Details

• Work Assignment: On Site
• Relocation support available
• Work Location Assignment:On Premise

The annual base salary for this position ranges from $68,600.00 to $114,300.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 7.5% of the base salary.

We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments.

• 401(k) plan with Pfizer Matching Contributions
• additional Pfizer Retirement Savings Contribution
• paid vacation
• holiday and personal days
• paid caregiver/parental and medical leave
• health benefits to include medical, prescription drug, dental and vision coverage

Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com).

Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Candidates must be authorized to be employed in the U.S. by any employer.

U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.

Sunshine Act

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

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Research and Development