Senior Scientist - Chemical Engineer for API Manufacturing Process Development

Pfizer; Groton (CT); In loco; USD 94.000 - 156.000; Tempo pieno

Vantaggi offerti da questo lavoro

Relocation assistance

Comprehensive benefits

Descrizione del lavoro

Pfizer seeks a Senior Scientist-Chemical Engineer to join the API Process Development team in Groton, CT. The role develops API processes, designs experiments, and transfers technology to manufacturing sites. Strong modeling, lab skills, and cross‑functional collaboration are essential.

Requirements include advanced degrees in Chemical Engineering with heavy emphasis on reaction engineering, kinetics, and process modeling. Relocation and a comprehensive benefits package are available.

Competenze

• BS with 9+ years, MS with 7+ years, or PhD with 0+ years in Chemical Engineering.
• Expertise in reaction engineering and kinetic modeling from experiments.
• Strong fundamentals in reactor design, thermodynamics, transport phenomena, and process modeling.

Mansioni

• Design and perform lab experiments to develop and optimize API manufacturing unit operations.
• Assess scalability and robustness for large‑scale API processes.
• Develop and apply new batch, semi-batch, and continuous flow technologies.
• Lead technology transfer to internal sites and external partners; support process validation.
• Apply process simulation and statistics to characterize kinetics and transport phenomena.
• Prepare internal reports and present findings to transfer knowledge to manufacturing.
• Develop digital tools to accelerate workflows and stay current with literature.
• Contribute to NDA CMC sections and respond to data verification and inspections.

Conoscenze

Reaction engineering

Kinetic modeling

Process modeling

Laboratory skills

Team collaboration

Formazione

BS in Chemical Engineering

MS in Chemical Engineering

PhD in Chemical Engineering

Strumenti

gPROMS

Aspen

DynoChem

VisiMix

COSMOtherm

Python

DOE software

Descrizione del lavoro

Use Your Power for Purpose

At Pfizer, our purpose is to deliver breakthroughs that change patients’ lives. Central to this mission is our Research and Development team, which strives to translate advanced science and cutting-edge technologies into impactful therapies and vaccines. Whether you are involved in discovery sciences, ensuring drug safety and efficacy, or supporting clinical trials, your role is crucial. You will leverage innovative design and process development capabilities to accelerate the delivery of best-in-class medicines to patients globally.

What You Will Achieve

We are seeking a highly motivated chemical engineer for the role of Senior Scientist-Chemical Engineer to join our API Process Development team within Chemical Research and Development (CRD) in Groton, CT. You will join a diverse team responsible for developing Active Pharmaceutical Ingredients (API) processes for use at manufacturing plants across Pfizer’s network. Chemical engineering principles contribute to the successful development, optimization and scale up of API manufacturing processes. You will design and perform engineering-related laboratory experiments, integrating process modeling, statistics, and automation. Strong communication, high technical aptitude, and creativity to foster original ideas are required for success in this position.

How You Will Achieve It

• Apply chemical engineering principles to design and perform laboratory experiments to develop and optimize API manufacturing unit operations.
• Assess scalability and robustness for API processes with understanding of large-scale pharmaceutical manufacturing equipment, capabilities, and operations.
• Evaluate, develop, and apply new process technologies (batch, semi-batch, and continuous flow) to deliver safe, efficient, and sustainable API processes.
• Lead technology transfer of processes to internal clinical and commercial API manufacturing sites and external partners. May spend time at the commercial launch site supporting process validation activities.
• Apply process simulation and statistical tools to characterize the kinetic, thermodynamic, and transport phenomena impacting various unit operations, such as reaction, extraction, distillation, crystallization, filtration, and drying.
• Prepare internal research reports and technical presentations summarizing API process development activities to capture process knowledge and transfer process understanding to Pfizer’s commercial manufacturing.
• Champion the development of new technology and digital tools to expedite new and existing workflows and capabilities.
• Remain current with the process engineering and chemistry literature. May collaborate on and author external publications and present research at external conferences.
• Contribute to the preparation of the Chemistry and Manufacturing Controls (CMC) section of the New Drug Application (NDA). Participate in data verification, Pre-Approval Inspection (PAI) preparedness, and post-submission query response.

Here Is What You Need (Minimum Requirements)

• BS with at least 9 years of experience or MS with at least 7 years of experience or PhD with 0+ years of experience in Chemical Engineering
• Candidates with additional years of work experience will be considered for an appropriate level for their background
• Expertise in reaction engineering, including experience developing and validating kinetic models from experimental data
• Excellent knowledge of chemistry and chemical engineering principles and sound understanding of chemical reactor design, thermodynamics, transport phenomena, engineering statistics, and process modeling
• Outstanding laboratory skills, attention to detail, and ability to solve technical problems
• Exceptional interpersonal, multi-disciplinary team collaboration, and communication skills

Bonus Points If You Have (Preferred Requirements)

• Working knowledge of reaction modeling, property prediction, and process simulation tools including: gPROMS, Aspen, DynoChem, VisiMix, and COSMOtherm
• Experience designing, developing, and scaling continuous processes (flow chemistry)
• A good foundational understanding of organic chemistry
• Working knowledge of crystallization development
• Working knowledge of Design of Experiment (DOE) studiesand statistical analysis
• Working knowledge of analytical techniques such as HPLC/UPLC, MS, PXRD, DSC, TGA, and NMR
• Working knowledge of application of in-situ analysis tools to process understanding including: FTIR, Raman, FBRM, UV/Vis
• Computational fluid dynamics (CFD) expertise in M-Star or Fluent
• Programing experience, including Python and/or Matlab
• Applied data science methods, such as machine learning and AI
• Experience in automating laboratory equipment and processes including use of LabView

PHYSICAL/MENTAL REQUIREMENTS

Ability to work in a laboratory environment performing experiments in a laboratory fume hood. Ability to perform complex data analysis

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

Some international travel associated with technology transfer to clinical manufacturing plant and commercial new product launch site may be required.

Relocation support available

Work Location Assignment:On Premise

Last day to apply : Nov 20th 2026

The annual base salary for this position ranges from $93,600.00 to $156,000.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Candidates must be authorized to be employed in the U.S. by any employer.

U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Pfizer endeavors to make www.pfizer.com/careers accessible to all users. If you would like to contact us regarding the accessibility of our website or need assistance completing the application process and/or interviewing, please email [e-mail]. This is to be used solely for accommodation requests with respect to the accessibility of our website, online application process and/or interviewing. Requests for any other reason will not be returned.

To learn more about acceptable and prohibited uses of AI during the recruitment process, please review our candidate AI-use guidelines available on Pfizer Careers.

Research and Development