Specialist, LC-MS Analytical Development

DNA Script; Mississippi; On-site; USD 60,000 - 80,000; Full time

Job summary

An innovative company in the biotech sector is seeking an LC-MS Analytical Development Specialist to spearhead analytical projects focused on oligonucleotide analysis and biomolecules. This pivotal role will involve leading the development and validation of cutting-edge analytical methods while collaborating with R&D teams to drive novel therapeutics. The successful candidate will leverage their expertise in mass spectrometry and analytical development to enhance the company's practices, contributing to significant advancements in life sciences. Join a dynamic team and make a meaningful impact in biotechnology through advanced analytics.

Qualifications

• 5+ years of experience in LC/MS analytical development on biomolecules.
• Deep expertise in UHPLC and mass spectrometry data analysis.

Responsibilities

• Lead development and validation of new analytical methods.
• Manage oligonucleotide sample analysis and collaborate with R&D teams.
• Drive method transfer to QC and ensure robustness for scale-up.

Skills

Mass Spectrometry

Analytical Development

Oligonucleotide Analysis

UPLC/MS

Data Analysis

Collaboration

Communication Skills

Education

MSc in Analytical Chemistry

PhD in Analytical Chemistry

Tools

UPLC

Capillary Electrophoresis

Automation Robotics

Job description

DNA Script is a leading company in manufacturing de novo synthetic nucleic acids using enzymatic DNA synthesis (EDS) technology. The company aims at accelerating innovation in life science and technology through the decentralization of rapid, on demand and high-quality DNA synthesis. DNA Script's approach leverages nature's billions of years of evolution in synthesizing DNA to set a new standard for customizing nucleic acid synthesis thus accelerating discovery in genetics, genomics, and synthetic biology. Discovery disciplines with profound impacts upon humanity such as biopharma, translational genetics and even molecular information storage all start with synthetic DNA. The company has recently initiated the commercialization of its first EDS powered platform, the SYNTAX system.

To date, DNA Script has raised over $315M of financing, with leading investors such as Coatue Management, Fidelity Management and Research, Catalio Capital Management, Casdin Capital, LSP, Bpifrance Large Ventures, Danaher, Illumina Ventures, Agilent, Merck Ventures, Sofinnova Partners, Kurma Partners and Eurazeo.

DNA Script also partners on technology and product development with leading organizations such as DARPA, IARPA, Moderna Therapeutics, GE Research, Illumina, the Broad Institute, Harvard University, Institut Pasteur and the French Department of Defense.

DNA Script has its research and manufacturing facilities headquartered in Paris, France, and is in the process of expanding its commercial and development teams in South San Francisco.

Job Description

We’re Hiring: LC-MS Analytical Development Specialist | Shape the Future of Biotech

Are you passionate about mass spectrometry and biotech innovation? Do you thrive in a collaborative, fast-paced environment where your expertise makes a real impact? We’re looking for a LC-MS Analytical Development Specialist to become our go-to expert in Mass Spectrometry and help drive forward cutting-edge analytical solutions.

About the Role

As our in-house LC-MS expert, you'll lead analytical development projects centered on oligonucleotide analysis and other biomolecules, using state-of-the-art UPLC/UV, UPLC/MS (SQ, Q-ToF), and capillary electrophoresis systems. Your work will directly support the development of novel therapeutics and tools for the life sciences.

This is a highly visible role within the company—one where your technical leadership will contribute not just to project success, but to the standardization, innovation, and scalability of our analytical practices.

What You’ll Do

1. Lead the development and validation of new analytical methods (sample prep, UPLC/MS, etc.) and improve existing ones.
2. Manage oligonucleotide sample analysis, collaborating closely with R&D teams to interpret multi-technique results.
3. Take part in routine and high-throughput analyses, supporting projects across the company.
4. Drive method transfer to QC and ensure robustness for future scale-up.
5. Own instrument performance: maintenance, qualification, SOPs, logbooks, and system suitability testing.
6. Author high-quality protocols and technical reports, and contribute to scientific reviews and continuous learning.
7. Promote cross-team collaboration and act as an analytical science ambassador within the organization.

Must-Haves:

1. MSc or equivalent in Analytical Chemistry, Biochemistry, or related field.
2. 5+ years’ experience in analytical development using LC/MS (low and high resolution) on biomolecules.
3. Deep expertise in UHPLC and mass spectrometry data analysis, including software tools.
4. Strong interpersonal and communication skills – French and English proficiency required.
5. Self-motivated and team-oriented with a hands-on, proactive mindset.

Nice-to-Haves:

1. PhD in Analytical Chemistry
2. Industry experience (biotech, pharma, start-up environments)
3. Familiarity with automation, SPE, and liquid handling robotics

Ready to make your mark?
Apply now and help us push the boundaries of biotechnology through advanced analytics.