Spatial Sequencing Associate

Uncover; California, Northern (MO, KY); Hybrid; USD 75,000 - 88,000; Full time

Benefits offered by this job

Equity compensation

Job summary

Singular Genomics is seeking a Spatial Sequencing Associate 2 to join a collaborative team of engineers and scientists. You will run customer tissue samples on the G4X Spatial Sequencer, overseeing antibody activity assays and immunoassay workflows across diverse tissues.

The ideal candidate has experience in molecular biology techniques, immunoassays, and fluorescence readouts; knowledge of NGS instrumentation and spatial biology platforms is a strong plus.

Qualifications

• BS in a science/engineering field or 5 years of equivalent experience.
• Strong molecular biology laboratory skills and record-keeping.
• Hands-on multiplexed and immunoassay workflows required.
• Experience with lab equipment upkeep and troubleshooting.

Responsibilities

• Execute experiments to characterize antibody activity in tissue via IHC/IF.
• Support antibody validation and spatial biology workflows across tissues.
• Operate the G4X spatial sequencer daily.
• Prepare customer samples for spatial sequencing.
• Load consumables and program sequencing runs.
• Perform primary analysis of sequencing data.
• Maintain instrumentation and daily sequencing metrics.
• Document data capture, logs, and inventory records.
• Contribute to late-stage workflow optimization for product launch.
• Forecast usage and manage consumables inventory.
• Document logbooks and inventory records.
• Collaborate in a small interdisciplinary team on new tech.
• Adhere to safety and quality standards.

Skills

Immunoassays

Multiplexed workflows

Fluorescence imaging

Documentation

Education

BS in Life Science or Engineering

Tools

SDS-PAGE

NGS instrumentation

Flow cell handling

Microscopy equipment

Job description

ABOUT SINGULAR GENOMICS

Singular Genomics is inventing at the forefront of genomics, one of the world’s fastest-growing industries. The commercially available G4® Sequencing Platform is a powerful, highly versatile benchtop genomic sequencer designed to produce fast and accurate results. In addition, the company is currently developing the G4X™ Spatial Sequencer, an upgrade to the G4, which will leverage Singular’s proprietary sequencing technology, applying it as an in situ readout for transcriptomics, proteomics and fluorescent H&E in tissue, with spatial context. Singular Genomics’ mission is to empower researchers and clinicians to advance science and medicine. We foster a culture of creativity and technical excellence, both catalysts for innovation. We celebrate diversity, emphasize collaboration and, as we rapidly mature, we are constantly looking at ways we can do better for our people. Our Headquarters are located on the Torrey Pines Mesa, in La Jolla, California at the center of the biotech hub. Our Manufacturing facility is in Sorrento Valley.

Position Summary

As a Spatial Sequencing Associate 2, you will support a collaborative team of engineers and scientists to run customer tissue samples on the G4X Spatial Sequencer. The ideal candidate will have experience in standard molecular biology techniques for handling nucleic acids (e.g., DNA/RNA purification, PCR amplification, isothermal amplification, and library preparation for next generation sequencing) and be familiar with common enzymes that interact with DNA/RNA. Experience with next generation DNA sequencing (instrumentation and analysis) and handling of tissues on flow cells is a plus. Expertise in immunoassays (IHC, IF, ISH), familiarity with microscopy-based readouts (particularly fluorescence) and experience with multiplexed assay workflows are essential. You will provide guidance to assay developers to identify appropriate controls, optimize workflows, and implement enhancements that improve assay robustness and reliability.

Responsibilities

• Execute experiments to characterize antibody activity using immunofluorescence or IHC across diverse tissue types and conditions.
• Support antibody validation efforts using molecular biology techniques (e.g. SDS-PAGE), immunoassays, and/or G4X spatial biology assay across various tissue types.
• Day-to-day operation of the G4X sequencer.
• Manually prepare customer samples provided for spatial sequencing.
• Load consumables and program sequencing runs.
• Perform primary analysis of run data.
• Perform regular instrument maintenance.
• Daily run metrics and quality of sequencing performance review.
• Complete documentation to support data capture, forms, logbooks, and inventory batch records.
• Contribute to late-stage optimization of spatial biology workflows, ensuring readiness for product launch.
• Scheduling, usage forecasting and inventory management of consumables.
• Complete documentation to support logbooks, and inventory batch records.

Qualifications

• BS in a Science or Engineering field or 5 years of working experience in equivalent field.
• Strong molecular biology laboratory skills, demonstrated by work experience.
• Hands-on experience with multiplexed and immunoassay workflows (required).
• Strong analytical and documentation skills; experience maintaining accurate, detailed records.
• Experience with running, maintaining, and troubleshooting lab equipment.
• Working knowledge of fluorescence microscopy and imaging-based readouts is a strong plus.
• Familiarity with spatial biology platforms and workflows is a strong plus.
• Experience interpreting NGS-based transcriptomic and proteomic data is a strong asset.
• Desire and ability to work in a small interdisciplinary team to develop new technologies at a rapid pace.

The estimated base salary range for this role based in the United States of America is: $74,900 - $88,100. Additionally, this role is eligible for to receive equity as part of the compensation package. Compensation decisions are dependent on several factors including, but not limited to, an individual’s qualifications, location where the role is to be performed, internal equity, and alignment with market data. Should the level of the role change during the hiring process, the applicable salary range may be updated accordingly.

Singular Genomics is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

Singular Genomics is committed to working with and providing reasonable accommodations to job applicants with physical or mental disabilities. Applicants with a disability who require a reasonable accommodation for any part of the application or hiring process can provide their name and contact information to our Accommodations team at [e-mail] . Your request will be responded to as soon as possible.