Senior Vice President, Medical Affairs

tangotherapeutics; Boston (MA); On-site; USD 450,000 - 750,000; Full time

Job summary

Tango Therapeutics in Boston, MA is seeking a Senior Vice President, Global & US Medical Affairs to define and execute a unified medical affairs strategy as the company scales from research to commercial.

The SVP will build global medical infrastructure, align clinical development, regulatory, and market access, and ensure our clinical promise translates into robust scientific narratives and value for patients.

Qualifications

• Advanced clinical degree required (MD/DO preferred).
• Specialized clinical training in oncology (Board Certification preferred).
• 15+ years of experience in medical affairs or related leadership roles.

Responsibilities

• Global & US Strategic Leadership: develop and execute an integrated Global and US Medical Affairs strategy.
• External Engagement & KOL Strategy: lead external medical engagement and build collaborations with key opinion leaders.
• Evidence Generation & Medical Communications: oversee HEOR/RWE, publications, and medical information to support launch and lifecycle management.

Education

MD/DO

Board Certification in Oncology

PhD/PharmD considered

Job description

Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer. Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer. This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing. Tango's labs and offices are located at 201 Brookline Avenue, in the vibrant Fenway area of Boston, Massachusetts.

Summary

The Senior Vice President (SVP), Global & US Medical Affairs is a critical enterprise leader responsible for defining, building, and executing a unified, world-class medical affairs strategy for Tango Therapeutics on a global scale. As Tango transitions from a research-stage biotech into a fully integrated commercial organization, this executive will build and scale the global and US medical infrastructure required to support the successful launch and lifecycle management of our precision synthetic lethality oral oncology medicines. Reporting directly to the Chief Commercialization Officer (CCO) and serving as a key member of the Commercial Leadership Team, the SVP will act as the senior physician leader and strategic bridge between clinical development, regulatory affairs, and commercialization. This leader will ensure that the clinical promise of our assets is translated into robust, globally aligned scientific narratives, driving external engagement, evidence generation, and medical education to support patient access and optimize product value worldwide.

Your Role

Global & US Strategic Leadership and Cross-Functional Integration

• Unified Strategy: Develop, articulate, and execute an integrated Global and US Medical Affairs strategy that aligns with overall corporate objectives, clinical development plans, and global commercial strategies
• Cross-Functional Partnership: Act as a critical strategic medical partner to internal stakeholders (Clinical Development, Regulatory Affairs, Market Access, and Commercial) to ensure that the Global Medical Affairs strategy seamlessly supports early-stage asset development and transitions pipeline assets into successful commercial products
• Commercial Alignment: Provide strategic medical input into global commercial plans, marketing materials, and product positioning to ensure scientific integrity and alignment with clinical realities across all target markets
• Lifecycle Management: Synthesize complex clinical/scientific data and global insights from the medical community to proactively inform clinical trial design, target product profiles, and lifecycle management plans

External Engagement & Global KOL Strategy

• Senior Scientific Voice: Act as the primary physician leader, company spokesperson, and external scientific representative for Tango Therapeutics in both US and international markets
• KOL Development: Identify, cultivate, and maintain strong, collaborative relationships with global and regional key opinion leaders (KOLs), clinical investigators, health systems, medical societies, and academic institutions, particularly within the oncology space
• Field Medical Leadership: Provide strategic direction to the US Field Medical team and guide the expansion of an international field medical strategy, ensuring deep scientific exchange, gathering of clinical insights, and support for investigator-initiated studies (IIS)

Evidence Generation, Medical Communication & Patient Focus

• Evidence Generation (HEOR & RWE): Serve as the medical lead for pre-launch, launch, and post-launch evidence generation globally, and oversee strategies for real-world evidence (RWE) to support the global value proposition of Tango's portfolio
• Scientific Communications: Oversee the development and execution of a strategic global publication plan, scientific communication strategy, and core global materials (e.g., congress plans), ensuring the accurate, timely, and compliant dissemination of clinical data
• Medical Information & Education: Establish and oversee the Medical Information function to provide accurate, balanced responses to unsolicited inquiries globally; manage strategies for continuing medical education and early access/expanded access programs
• Compliance & Governance: Ensure all Medical Affairs activities are conducted with the highest level of integrity and in full compliance with applicable legal, regulatory (e.g., FDA, EMA), and ethical guidelines, providing medical governance oversight for promotional materials

What You Bring

Education & Experience

• Advanced clinical degree required (MD or DO strongly preferred; PharmD or PhD considered with exceptional clinical oncology experience)
• Specialized clinical training in oncology (Board Certification preferred)
• 15+