Senior Upstream Process Engineer – GMP Biotech

Piper Companies; Holly Springs (NC); On-site; USD 130,000 - 155,000; Full time

Benefits offered by this job

Medical coverage

Dental coverage

Vision coverage

401K

Job summary

Piper Companies is seeking a Process Engineer to join a leading biotechnology manufacturing organization. This Process Engineer will provide hands‑on support for upstream manufacturing operations with a strong focus on process equipment performance, production support, and technical troubleshooting within a GMP environment.

This opportunity is ideal for an engineer who enjoys working directly with manufacturing systems, investigating operational issues, and partnering with cross‑functional teams

Qualifications

• Bachelor’s degree in Chemical Engineering or related engineering discipline; Chemical Engineering background strongly preferred.
• 6+ years of experience supporting manufacturing process engineering activities within a regulated production environment.
• Demonstrated experience working with stainless steel bioprocess equipment, including tanks, filtration systems, bioreactors, and associated utility systems.
• Strong troubleshooting capabilities involving equipment operation, process controls, temperature regulation, dissolved oxygen control, pH management, HMI systems, and production automation.
• Working knowledge of DeltaV systems with the ability to distinguish process‑related issues from automation‑related concerns and effectively support troubleshooting efforts.

Responsibilities

• Serve as the primary technical owner for media preparation equipment while providing support across upstream processing operations, including bioreactors, harvest systems, and inoculum equipment.
• Investigate and resolve manufacturing challenges involving process performance, equipment functionality, control systems, and production execution.
• Support commercial manufacturing activities by monitoring critical operations, providing real‑time technical guidance, and ensuring equipment readiness.
• Lead and contribute to deviation investigations, change management activities, root cause analyses, and corrective action implementation related to process equipment.
• Collaborate closely with maintenance, automation, instrumentation, and manufacturing teams to optimize equipment reliability and operational performance.

Skills

Process troubleshooting

Cross-functional collaboration

Regulated GMP environment familiarity

Bioprocess knowledge

Education

Bachelor’s degree in Chemical Engineering

Tools

DeltaV

HMI

Bioreactors

Filtration systems

Tanks

Job description

Piper Companies is seeking a Process Engineer to join a leading biotechnology manufacturing organization. This Process Engineer will provide hands‑on support for upstream manufacturing operations with a strong focus on process equipment performance, production support, and technical troubleshooting within a GMP environment.

This opportunity is ideal for an engineer who enjoys working directly with manufacturing systems, investigating operational issues, and partnering with cross‑functional teams