Senior Upstream Process Development Scientist, Biologics

MSD; Rahway (NJ); Sur place; USD 142 000 - 224 000; Plein temps

Avantages offerts par ce poste

Annual bonus

Long-term incentive

Medical, dental, vision

Résumé du poste

Merck & Co., Inc. in Rahway, NJ, seeks an Associate Principal Scientist to lead upstream process development for mammalian cell culture and fed-batch processes. This role focuses on high-yield, robust, scalable production and collaboration across discovery, development, and manufacturing teams.

Responsibilities include process development, characterization, and regulatory filing support to ensure smooth PPQ/BLA pathways. Strong leadership, communication, and problem-solving skills are essential.

Qualifications

• Technical background in mammalian cell culture and fed-batch processes for recombinant protein production.
• Knowledge of CHO cell biology, metabolism, media, and scale-up for large-scale production.
• Experience with DOE and multivariate data analysis; proficiency in statistical tools.

Responsabilités

• Lead upstream process development for first-in-human and commercial products.
• Drive process characterization and regulatory filing support (PPQs/BLAs).
• Collaborate with Discovery, Cell Line, Downstream, Analytical Sciences, and Manufacturing units.
• Advance platform processes through improvements to increase efficiency and reduce costs.
• Engage with external partners and publish findings; pursue patents as appropriate.

Connaissances

Cell culture

Fed-batch processes

CHO biology

Media development

Bioreactors

DOE

Statistical methods

JMP

SIMCA

Scale-up

Cross-functional collaboration

Communication

Process development

Tech transfer

Formation

Ph.D. with 4+ years

Master's with 8+ years

Outils

SIMCA

JMP

Description du poste

Merck & Co., Inc. in Rahway, NJ, seeks an Associate Principal Scientist to lead upstream process development for mammalian cell culture and fed-batch processes. This role focuses on high-yield, robust, scalable production and collaboration across discovery, development, and manufacturing teams.

Responsibilities include process development, characterization, and regulatory filing support to ensure smooth PPQ/BLA pathways. Strong leadership, communication, and problem-solving skills are essential.