Senior Statistical Geneticist: Cardiac Target Discovery

Cytokinetics; South San Francisco (CA); On-site; USD 185,000 - 215,000; Full time

Benefits offered by this job

Equity in stock options

Comprehensive health insurance

401k retirement benefits with match

Paid time off

Learning and wellness stipends

Job summary

Cytokinetics is seeking a statistical geneticist to translate genetic insights into cardiovascular and skeletal muscle therapies. You will work with large cohorts, sequencing data, and rich phenotypes to identify and prioritize therapeutic targets.

Responsibilities include GWAS and meta-analyses across biobanks, AI/ML phenotyping from EHR and imaging, and causal inference using Mendelian methods to guide target direction.

Qualifications

• PhD in Statistical Genetics, Human Genetics, Bioinformatics, Computational Biology or a related field with 4+ years post‑doctoral or industry experience.
• Experience analyzing large-scale genomic datasets, including GWAS and sequencing data.
• Ability to translate genetic associations into candidate therapeutic hypotheses or targets.

Responsibilities

• Perform common and rare variant association studies and meta‑analyses across biobanks (e.g., UK Biobank, All of Us, FinnGen) to discover and replicate associations across diverse ancestries
• Develop quantitative and longitudinal phenotypes from EHR and imaging (e.g., cardiac MRI, DEXA) using AI/ML methods to better capture disease biology
• Apply fine‑mapping, colocalization, Mendelian randomization and burden methods, including protein language model‑based variant prioritization, to identify causal genes and direction of effect
• Prioritize targets using genetic evidence for efficacy and safety (e.g., PheWAS, allelic series, protective variants) and partner with experimental teams on validation
• Build reproducible pipelines on research analysis platforms, and present findings internally, at conferences and in publications

Skills

Statistical genetics

R/Python

ML methods

Communication skills

Independent research

Education

PhD in Statistical Genetics

Tools

R

Python

UK Biobank

All of Us Workbench

FinnGen

Job description

Cytokinetics is seeking a statistical geneticist to translate genetic insights into cardiovascular and skeletal muscle therapies. You will work with large cohorts, sequencing data, and rich phenotypes to identify and prioritize therapeutic targets.

Responsibilities include GWAS and meta-analyses across biobanks, AI/ML phenotyping from EHR and imaging, and causal inference using Mendelian methods to guide target direction.