Senior Software Engineer - AI Platform Engineering

Mayo Clinic; Rochester (MN); Hybrid; USD 141,000 - 205,000; Full time

Benefits offered by this job

Health insurance

Dental coverage

Vision plan

HSA/FSAs

Job summary

Mayo Clinic is hiring a Senior Software Engineer for AI Platform Engineering to bridge high-scale systems architecture with frontier AI. You will help design and operate the Model & Agent Runtimes across a hybrid-cloud footprint, ensuring scalable, secure, and governed AI capabilities through MLOps practices.

You will lead the development of scalable back-end systems, focusing on containerization, orchestration, and observability while collaborating with cross-functional AI teams to accelerate

Qualifications

• Bachelor's degree in Computer Science/Engineering or related field with 5 years of experience OR Associate’s degree with 7 years of experience.
• Strong programming background, preferably Python, and knowledge of software development lifecycle and modern frameworks.
• Experience with Agile methodologies and observability practices in distributed systems.

Responsibilities

• Architect high-performance hosting environments for models and autonomous agents.
• Scale multi-tenant hybrid-cloud infrastructure across cloud and on-prem environments.
• Implement real-time monitoring, metrics, tracing, and automated evaluation in production.
• Participate in rotational platform operations ensuring reliability and uptime.
• Collaborate with AI teams to reduce friction and accelerate AI-driven value delivery.

Skills

Kubernetes

Python

Distributed systems

Observability

AI/ML basics

Education

Bachelor's Degree in Computer Science/Engineering

Associate degree in related field

Tools

GCP

AWS

Azure

Containerization

Job description

Trending

Job Description

This is a hybrid position and must be located within 100 miles of a Mayo Clinic campus for occasional on-site expectations based on business needs.

As a Senior Software Engineer for AI Platform Engineering, you will bridge the gap between high-scale systems architecture and frontier AI. You will be one of architects and builders of our Model & Agent Runtimes—the specialized engines that govern how models and autonomous agents execute across our hybrid-cloud footprint.

This isn't just about deployment; it’s about a platform-first mindset. You will ensure that AI capabilities are scalable, secure, and governed through world-class AgentOps, LLMOps, and MLOps practices.

What You’ll Do

• Architect the Future of Runtimes:Design and implement high-performance hosting environments for both specialized models and autonomous agents.
• Scale Hybrid-Cloud Infrastructure:Build multi-tenant platform capabilities that support seamless agent and model execution across diverse cloud and on-prem environments.
• Drive Operational Excellence:Implement robust solutions for real-time monitoring, distributed tracing, and automated evaluation of agents & models in production.
• Operational Stewardship:Act as a member of our rotational platform operational team, ensuring the reliability and uptime of critical AI services.
• Collaborate & Advocate:Partner with cross-functional AI teams to identify system friction, streamlining their workflows and accelerating the delivery of AI-driven value.

What You’ll Bring

• Deep Systems Expertise:Proven experience building scalable back-end systems, ideally with a focus on containerization and orchestration (Kubernetes).
• AI/ML Fluency:Strong understanding of the lifecycle of LLMs and autonomous agents, including inference optimization and RAG architectures.
• Operational Rigor:A track record of implementing observability (logging, metrics, tracing) in complex, distributed environments.
• Problem-Solving Mindset:The ability to turn abstract AI research into production-grade, hardened platform features.

Why this team?

We are moving beyond simple model serving. We are building the foundational "nervous system" for autonomous agents in a high-stakes environment where performance and governance are non-negotiable.

Qualifications

Required qualifications for this position include: Bachelor's Degree in Computer Science/Engineering or related field with 5 years of experience as noted below; OR an Associate’s degree in Computer/Science/Engineering or related field with 7 years of experience.

Have in-depth knowledge of software engineering with experience coding applications or services in a high-level programming language, preferably Python, and a basic knowledge of related fields. Demonstrated problem solving and time management skills. Possesses strong technical aptitude for designing and implementing software solutions. Experience with modern application development frameworks. Knowledge of professional software engineering practices & best practices for the full software development life cycle, including coding standards, code reviews, source control management, build processes, testing, and operations. Deep hands-on technical expertise, excellent verbal and written communication skills. Experience with Agile software development techniques.

Preferred qualifications

• Master's degree in Computer Science/Engineering or related field.
• Ability to use a wide variety of open-source technologies and cloud-based services.
• Experience writing software for the cloud (GCP, AWS, Azure).
• Experience in databases, analytics, big data systems or business intelligence products.
• Experience building high-performance, highly available and scalable distributed systems.
• Experience developing software for healthcare related industries.

Authorization to work and remain in the United States, without necessity for Mayo Clinic sponsorships now, or in the future (for example, be a U.S. Citizen, national, or permanent resident, refugee, or asylee). Mayo Clinic does not participate in the F-1 STEM OPT extension program.

About Us

Why Mayo Clinic

Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans – to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic.

Benefits Highlights

• Medical:Multiple plan options.
• Dental:Delta Dental or reimbursement account for flexible coverage.
• Vision:Affordable plan with national network.
• Pre-Tax Savings:HSA and FSAs for eligible expenses.
• Retirement: Competitive retirement package to secure your future.

About the Team

Just as our reputation has spread beyond our Minnesota roots, so have our locations. Today, our employees are located at our three major campuses in Phoenix/Scottsdale, Arizona, Jacksonville, Florida, Rochester, Minnesota, and at Mayo Clinic Health System campuses throughout Midwestern communities, and at our international locations. Each Mayo Clinic location is a special place where our employees thrive in both their work and personal lives. Learn more about what each unique Mayo Clinic campus has to offer, and where your best fit is.

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender identity, sexual orientation, national origin, protected veteran status or disability status. Learn more about the "EOE is the Law" . Mayo Clinic participates in E-Verify and may provide the Social Security Administration and, if necessary, the Department of Homeland Security with information from each new employee's Form I-9 to confirm work authorization.

Job Info

• Job Identification 394355
• Job Category Software Engineering
• Posting Date 10/23/2026, 10:04 PM
• Job Schedule Full time
• Locations 55901
• Benefits Eligible Yes
• Remote worker Flexibility of both remote and on-site work
• Compensation Detail $141,024 - $204,526 / year
• Schedule Details Monday - Fridays; 8:00 AM to 5:00 PM CST. This is a hybrid position and must be located within 100 miles of a Mayo Clinic campus for occasional on-site expectations based on business needs.
• Union Job No
• Area of Interest 1 Information Technology
• Marketing Category 1 Information Technology
• International Assignment No
• Overtime Rule Salaried employee who does not receive overtime pay