Senior Software Engineer

Proscia; Philadelphia (Philadelphia County); On-site; USD 140,000 - 190,000; Full time

Job summary

Proscia, based in Philadelphia, is transforming pathology with AI-powered software and digital imaging. As a Senior Software Engineer, you’ll help build the platform powering research and clinical workflows, spanning scalable backend services, APIs, modern web applications, and cloud-native infrastructure.

You’ll work with TypeScript, Node.js/Deno, PostgreSQL, and Vue, contribute to automated testing, and collaborate in an Agile environment to deliver reliable, observable software that advances

Qualifications

• 5+ years of professional software engineering on production-grade apps.
• Strong TypeScript and Node.js/Deno experience in enterprise environments.
• Experience building RESTful APIs and service-oriented apps.
• Experience with Vue.js or similar frontend frameworks (React/Angular).
• Familiarity with distributed systems, microservices, API-driven architectures.
• Experience with PostgreSQL in production, ORM usage, and SQL optimization.
• Strong automated testing using Vitest or Playwright.
• Experience deploying cloud-native apps on AWS or Azure.
• Experience with Docker, Kubernetes, CI/CD, and modern software practices.
• Familiarity with Git workflows and Agile/Scrum.

Responsibilities

• Design, develop, test, and deploy scalable platform services.
• Build and maintain modern APIs and web apps with TypeScript and Vue.
• Collaborate in an Agile/Scrum team to deliver features.
• Ensure interoperability and architectural direction across Proscia.
• Improve frontend UX for data-intensive applications.
• Adopt an AI-first mindset and integrate modern tools into workflows.

Skills

TypeScript

Node.js/Deno

RESTful APIs

Vue.js

Distributed systems

Microservices

API-driven architectures

Automated testing

Cloud-native applications

CI/CD

Git workflows

Agile/Scrum

Problem solving

Communication

Collaboration

Observability

Tools

Docker

Kubernetes

AWS

Azure

PostgreSQL

Job description

About Proscia

Proscia is revolutionizing pathology, the last major frontier in healthcare to embrace digital. As a leader in pathology AI software, we are empowering pathologists and scientists to transition from traditional microscope-based workflows to digital, AI-driven approaches, unlocking new possibilities in precision medicine.

About Proscia

Proscia is revolutionizing pathology, the last major frontier in healthcare to embrace digital. As a leader in pathology AI software, we are empowering pathologists and scientists to transition from traditional microscope-based workflows to digital, AI-driven approaches, unlocking new possibilities in precision medicine.

The digital pathology market is experiencing explosive growth as advances in AI enable unprecedented insights into diseases like cancer. Pathology is central to medicine, and the shift to AI-powered solutions is not just modernizing workflows—it’s transforming how diseases are diagnosed, treated, and understood. Predictions for the future of pathology show a tidal wave of adoption, with experts describing the field as “poised for the next major breakthrough” in healthcare innovation.

Backed by over $100 million in funding from leading healthcare and technology investors, Proscia is at the forefront of this revolution. Joining Proscia means being part of a company at the cutting edge of healthcare innovation, where the possibilities are limitless. With the convergence of AI, precision medicine, and digital pathology, we’re not just changing pathology—we’re redefining what’s possible in medicine.

About The Role

As a Senior Software Engineer, you’ll help build and evolve the software platform powering the future of digital pathology and medical imaging. You’ll work across the application stack — from scalable backend services and APIs to modern web applications and cloud-native infrastructure — delivering enterprise-grade software used in real-world healthcare environments.

We’re looking for an engineer who is equally comfortable designing distributed systems, building intuitive user experiences, and leveraging modern AI-assisted development workflows. You’ll collaborate closely with cross-functional engineering, product, and operations teams to deliver highly scalable, reliable, and maintainable solutions.

Our platform combines high-performance medical imaging, modern web technologies, microservices architecture, and cloud-native infrastructure to solve meaningful problems in healthcare and diagnostics.

The ideal candidate has strong experience with TypeScript, Node.js/Deno, PostgreSQL, modern frontend development (Vue preferred), automated testing, and service-oriented architectures — along with a passion for building high-quality software and continuously improving engineering practices.

Key Responsibilities

• Design, develop, test, and deploy scalable services and applications across the platform stack
• Build and maintain modern APIs, microservices, and web applications using TypeScript and Vue
• Collaborate within a high-performing Agile/Scrum team to define, estimate, and deliver impactful features
• Partner with engineering teams across Proscia to ensure interoperability, platform consistency, and shared architectural direction
• Contribute to frontend architecture and user experience improvements for complex, data-intensive applications
• Adopt an AI-first mindset by integrating modern intelligent tools into your engineering workflows for system navigation, configuration validation, and complex troubleshooting. We expect our engineers to already be leveraging these technologies as a core part of their professional practice.
• Demonstrated experience developing with large language models, agentic pipelines, or AI agents, along with a proven track record of applying advanced AI-assisted development techniques to solve sophisticated technical challenges.
• Fluency in prompt engineering, tool-use patterns, and the evaluation of AI systems, including the ability to identify necessary guardrails and ensure the reliability of AI-generated technical outputs.
• Participate in architectural design discussions and help drive best practices for scalability, observability, maintainability, and performance
• Improve developer productivity through automation, testing, CI/CD, and platform tooling
• Continuously evaluate emerging technologies, frameworks, and engineering practices to improve the platform

Required Experience

• 5+ years of professional software engineering experience building production-grade applications
• Strong experience with TypeScript and Node.js/Deno in enterprise application environments
• Experience building and maintaining RESTful APIs and service-oriented applications
• Experience developing modern web applications using Vue.js or comparable frontend frameworks such as React or Angular
• Strong understanding of distributed systems, microservices, and API-driven architectures
• Experience working with PostgreSQL in production environments, including ORM usage and direct SQL optimization
• Strong automated testing experience using frameworks such as Vitest and Playwright
• Experience building and deploying cloud-native applications in AWS or Azure
• Prior experience with containerization and orchestration technologies such as Docker and Kubernetes
• Experience with CI/CD pipelines and modern software delivery practices
• Familiarity with Git-based workflows and Agile/Scrum development methodologies
• Excellent problem-solving, communication, and collaboration skills
• Passion for delivering high-quality, maintainable, and observable software systems

Desirable Experience

• Experience designing and scaling distributed systems in production environments
• Practical experience with microservices architecture and understanding associated trade-offs
• Experience building highly interactive or data-intensive frontend applications
• Familiarity with medical imaging, healthcare software, or regulated environments
• Experience working with large-file or high-throughput systems such as image processing or streaming platforms
• Understanding of event-driven architectures and messaging systems such as RabbitMQ, Kafka, or AWS SQS
• Experience with caching strategies, load balancing, API gateways, and performance optimization techniques
• Knowledge of database optimization strategies including indexing, partitioning, and connection pooling
• Experience with observability and monitoring tools for logs, metrics, and distributed tracing
• Familiarity with infrastructure as code tools such as Terraform or CloudFormation
• Experience participating in architectural reviews and translating technical designs into implementation plans
• Experience mentoring engineers and contributing to engineering culture and standards

Beyond Just Work

As a company in healthcare, we want our people to be happy and healthy, in and out of the office. In addition to competitive pay, we ensure everyone on our team is supported with savings, schedule, and insurance options that promote long‑term health and personal growth.

Our office environment is designed for creativity and agility: with walls as notepads and couches for collaboration. We’re located in the heart of Philadelphia, with views of the city so you can spend your time focusing on what matters most.

At Proscia, we don’t just accept differences — we celebrate them, we support them, and we thrive on them for the benefit of our employees, our products, and our community. Proscia is proud to be an equal opportunity workplace.

Why This Role Matters

At Proscia, we’re transforming pathology through software, AI, and modern medical imaging technology. You’ll work on meaningful technical challenges involving cloud-native systems, enterprise applications, high-performance image workflows, and modern web platforms — all while helping advance the future of precision medicine and diagnostics.