Senior Scientist, Upstream Processing

Glaxosmithkline; United States; Remote; USD 110,000 - 150,000; Full time

Benefits offered by this job

Healthcare

Pension plan

Shares and savings programme

Job summary

GlaxoSmithKline is seeking a Senior Scientist, Upstream Processing to lead manufacturing of clinical supply for investigational biopharmaceuticals. You will perform hands-on cGMP cell culture for early phase trials and drive independent projects with a focus on safety, compliance and quality.

You will collaborate across teams to ensure processes fit and scale, support tech transfer, and maintain rigorous documentation. This role is on-site in Upper Merion, PA with limited remote options.

Qualifications

• BS, MS, or PhD in Chemical Engineering, Biology, Chemistry, or related field.
• Minimum of 3 years of direct GMP manufacturing experience or upstream processing experience.
• Experience with cGMP large‑scale cell culture and clinical supply is a plus.

Responsibilities

• Leads the manufacture of clinical supply of investigational biopharmaceutical molecules. Specifically: hands‑on cGMP large scale cell culture for use in early phase clinical trials
• Leads or works on projects and assignments where independent action and a high degree of initiative and knowledge are required for execution or to provide recommendations
• Supports the technology transfer process through active participation in ensuring that new processes fit and execute consistently
• Troubleshoots problems in the execution of processing activities; proactively assesses options and impact and takes action to rectify or communicate to appropriate decision makers
• Identifies process improvement opportunities with impact on safety, compliance, and efficiency/cost
• Maintains and performs compliance checks for documentation in logs, media forms, batch records, and electronic systems in accordance with company policy and legal requirements
• Strives for Right First Time in the manufacture of investigational material through attention, focus, planning, and adherence to procedural and regulatory expectations

Skills

Data Integrity

Detail‑Oriented

Digital Fluency

Emergency Response

Financial Acumen

GxP Regulations

Lean Management

Manufacturing Processes

Problem Solving

Production Management

Project Coordination

Quality Compliance

Regulatory Compliance

Risk Awareness

Site Operations

Education

BS, MS, or PhD in Chemical Engineering, Biology, Chemistry, or related field

Tools

Job description

We create a place where people can grow, be their best, be safe, and feel welcome, valued and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programs, pension plan membership, and shares and savings programme. We embrace modern work practices; our Performance with Choice programme offers a remote or hybrid working model, empowering you to find the optimal balance between remote and in-office work.

Discover more about our company-wide benefits and life at GSK on our webpage Life at GSK | GSK

Find out more about GSK and R&D: Our approach to R&D

Senior Scientist, Upstream Processing

Join us as a Senior Scientist, Upstream Processing and play a key role in advancing scientific research that makes a real difference. You will work closely with diverse teams to design, carry out, and analyze experiments. Your insights will help shape innovative solutions that align with our mission to unite science, technology, and talent to get ahead of disease together. We value curiosity, teamwork, and a hands‑on approach to solving important challenges. This role offers meaningful growth and impact as you develop your career in a supportive environment.

We value curious, motivated scientists who take ownership, communicate clearly, and thrive in a collaborative environment. This role offers you a chance to grow your skills, make a meaningful impact, and contribute to GSK's mission of uniting science, technology, and talent to get ahead of disease together.

This role is located in Upper Merion, PA and requires working on-site. Hybrid or remote work options are not available for this position.

This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include some of the following

• Leads the manufacture of clinical supply of investigational biopharmaceutical molecules. Specifically: hands‑on cGMP large scale cell culture for use in early phase clinical trials
• Leads or works on projects and assignments where independent action and a high degree of initiative and knowledge are required for execution or to provide recommendations
• Supports the technology transfer process through active participation in ensuring that new processes fit and execute consistently
• Troubleshoots problems in the execution of processing activities; proactively assesses options and impact and takes action to rectify or communicate to appropriate decision makers
• Identifies process improvement opportunities with impact on safety, compliance, and efficiency/cost
• Maintains and performs compliance checks for documentation in logs, media forms, batch records, and electronic systems in accordance with company policy and legal requirements
• Strives for Right First Time in the manufacture of investigational material through attention, focus, planning, and adherence to procedural and regulatory expectations

Basic Qualifications

We are looking for professionals with these required skills to achieve our goals:

• BS, MS, or PhD in Chemical Engineering, Biology, Chemistry, or other engineering or scientific field.
• A minimum of 3 years of direct GMP manufacturing experience or upstream processing experience in a biotechnology manufacturing facility or Pilot Plant.

Preferred Qualifications

Please note the following skills are not necessary, just preferred, if you do not have them,

• Thorough knowledge of Good Manufacturing Practices (GMP) regulations.
• Demonstrates good interpersonal skills and communicates well both verbally and through written communications.
• Maintains a professional and productive relationship with area management and co-workers.
• Thorough knowledge of routine laboratory/plant equipment and demonstrates high level of technical expertise with working familiarity with several methods, techniques, laboratory procedures and processes.
• Possess in-depth knowledge of how to analyze and interpret experimental/process data.

Skills

• Data Integrity
• Detail‑Oriented
• Digital Fluency
• Emergency Response
• Financial Acumen
• GxP Regulations
• Lean Management
• Manufacturing Processes
• Problem Solving
• Production Management
• Project Coordination
• Quality Compliance
• Regulatory Compliance
• Risk Awareness
• Site Operations

Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases - to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we're committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

If you require an accommodation or other assistance to apply for a job at GSK, please contact the appropriate Recruitment Staff by emailing us at - [e-mail]

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit the Centers for Medicare and Medicaid Services (CMS) website at https://openpaymentsdata.cms.gov/