Senior Scientist, Translational Modeling & Simulation

Pfizer, S.A. de C.V; Cambridge (MA); Hybrid; USD 90,000 - 152,000; Full time

Job summary

A leading company in pharmaceuticals is seeking a Senior Scientist in Translational Modeling & Simulation to drive innovative drug development through quantitative pharmacology. This role involves collaboration with multidisciplinary teams to create mechanistic models and contribute to the clinical development process. Candidates will leverage their expertise in pharmacometrics to impact patient outcomes globally.

Qualifications

• Ph.D. degree or equivalent in relevant fields.
• 0 – 2 years of relevant experience in the pharmaceutical industry.
• Strong quantitative and statistical modeling skills.

Responsibilities

• Develop and implement mathematical models for pharmacology.
• Collaborate with biology to enhance preclinical-to-clinical models.
• Provide expert support for quantitative pharmacology studies.

Skills

Communication

Teamwork

Attention to detail

Education

Ph.D. in systems biology, pharmacometrics, pharmaceutical sciences, engineering, physics, mathematics

Tools

NONMEM

MatLab

Phoenix

Job description

Senior Scientist, Translational Modeling & Simulation

• United States - Massachusetts - Cambridge

We’re in relentless pursuit of breakthroughs that change patients’ lives. We innovate every day to make the world a healthier place.

To fully realize Pfizer’s purpose – Breakthroughs that change patients’ lives – we have established a clear set of expectations regarding “what” we need to achieve for patients and “how” we will go about achieving those goals.

Pfizer Research & Development serves as the beating heart of Pfizer's trailblazing product pipeline, the essence of our mission to bring life-changing medicines to the world.

Pfizer offers competitive compensation and benefits programs designed to meet the diverse needs of our colleagues.

At Pfizer, we deliver breakthroughs that transform patients' lives. Your work will directly impact the development of innovative therapies and vaccines, ensuring that we continue to deliver top-tier medicines to patients globally. By leveraging advanced science and cutting-edge technologies, you will help expedite the delivery of impactful treatments, improving the lives of patients around the world.

What You Will Achieve

The successful candidate will join the Translational Modeling and Simulation (TMS) team within Pfizer’s Department of Pharmacokinetics, Dynamics and Metabolism (PDM). As a core member of multidisciplinary project teams, the candidate will leverage principles and practices of quantitative translational pharmacology (PK/PD, PBPK, QSP) to influence decision making from project ideation through early clinical development.Emphasis will be in the diverse areas of internal medicine and inflammatory/immunological disorders, and include both biologics and small molecule modalities.

This role primarily involves interaction with other members of multidisciplinary project teams includng Biology, Medicinal Chemistry, BioMedicine Design, PDM, Drug Safety, Pharmaceutical Sciences, Clinical Pharmacology, and Clinical. Interaction with internal and external modeling and simulation experts is also expected.

How You Will Achieve It

In this role, you will:

• Work closely in multidisciplinary project teams to develop and implement appropriate mathematical models (mechanistic, semimechanistic, empirical) of pharmacology to aid in target selection, target prioritization, therapeutic modality selection, chemical/biotherapeutic optimization, biomarker characterization and early clinical trial design.
• Collaborate with research biology to help in the development of in vitro assays and in vivo models to generate data that inform preclinical-to-clinical, translational PK/PD models.
• Provide expert support to project teams to design, execute and interpret quantitative pharmacology studies.
• Partner with colleagues in Clinical Pharmacology and Pharmacometrics to develop end-to-end alignment in model-informed drug development (MIDD) plans and to collectively advance the science and impact of mechanistic modeling and simulation.
• Network as appropriate with global experts in the department and other groups to share learnings and enhance consistency in best practices across sites, disease areas, and interventionalmodalities.
• Keep up to date with emerging literature in the area of mechanistic modeling and simulation sciences.
• Continue to build a personal track record of publication in the area of PK/PD modeling and simulation and contribute to PDM’s external publication/presentation goals consistent with our sustained investments in the area of modeling and simulation.

Here Is What You Need (Minimum Requirements)

• Ph.D. degree or equivalent degree in systems biology, pharmacometrics, pharmaceutical sciences, engineering, physics, mathematics, or similar disciplines where modeling and simulation is emphasized; experience with modeling of biological systems is strongly preferred.
• 0 – 2 years of relevant experience in the pharmaceutical industry.
• Strong communication skills, ability to work independently and in teams, and attention to detail.
• Good team player and communicator; including good listening skills and the ability to effectively interact with colleagues with a variety of backgrounds.
• Self-starter with demonstrated ability to work in a small team with minimal technical supervision.
• Excellent understanding of theory, principles, and statistical aspects of advanced mathematical modeling and simulation.
• Ability to translate/condense/summarize outcomes of modeling and simulation analyses into information that can be understood by non-experts.
• Hands-on knowledge of the state-of-the-art modeling and simulation software and applications in the area of PK/PD modeling and simulation (e.g. NONMEM, MatLab, Phoenix, Berkeley-Madonna, SAAM II, ADAPT, ACSL, S-plus, R or comparable applications).
• An understanding of the basic principles of pharmacokinetics (e.g. non-compartmental, compartmental, PBPK).
• Ability to learn new areas of biological sciences and build on solid foundation of quantitative skills to develop mechanistically-relevant PK/PD models.
• Ability to keep up-to-date with and propose the implementation of scientific and technological developments in the area of PK/PD modeling and simulation.
• Motivation to develop a career as a hands-on, technical modeling and simulation expert in a preclinical drug discovery environment.
• Keen to interact as a modeling and simulation experts with matrix project teams working closely with PDM, Biology, and Clinical scientists.
• Strong belief that modeling and simulation can have a significant positive impact on research projects.
• Commitment to the development of self and others.
• Motivation to share technical expertise with others.

Bonus Points If You Have (Preferred Requirements)

• Familiarity with the phases of drug discovery and development, with particular emphasis in the area of translational research, is helpful but not required.
• Experience with quantiative mechanistic modeling of the pharmacokinetic and PKPD behavior of biologics preferred.

Experience in clinical pharmacology and/or pharmacometrics

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

Occasional travel, 1-2 times a year, may be needed.

Relocation support available

Work Location Assignment:Hybrid

Use Your Power for Purpose

At Pfizer, we deliver breakthroughs that transform patients' lives. Your work will directly impact the development of innovative therapies and vaccines, ensuring that we continue to deliver top-tier medicines to patients globally. By leveraging advanced science and cutting-edge technologies, you will help expedite the delivery of impactful treatments, improving the lives of patients around the world.

What You Will Achieve

The successful candidate will join the Translational Modeling and Simulation (TMS) team within Pfizer’s Department of Pharmacokinetics, Dynamics and Metabolism (PDM). As a core member of multidisciplinary project teams, the candidate will leverage principles and practices of quantitative translational pharmacology (PK/PD, PBPK, QSP) to influence decision making from project ideation through early clinical development.Emphasis will be in the diverse areas of internal medicine and inflammatory/immunological disorders, and include both biologics and small molecule modalities.

This role primarily involves interaction with other members of multidisciplinary project teams includng Biology, Medicinal Chemistry, BioMedicine Design, PDM, Drug Safety, Pharmaceutical Sciences, Clinical Pharmacology, and Clinical. Interaction with internal and external modeling and simulation experts is also expected.

How You Will Achieve It

In this role, you will:

• Work closely in multidisciplinary project teams to develop and implement appropriate mathematical models (mechanistic, semimechanistic, empirical) of pharmacology to aid in target selection, target prioritization, therapeutic modality selection, chemical/biotherapeutic optimization, biomarker characterization and early clinical trial design.
• Collaborate with research biology to help in the development of in vitro assays and in vivo models to generate data that inform preclinical-to-clinical, translational PK/PD models.
• Provide expert support to project teams to design, execute and interpret quantitative pharmacology studies.
• Partner with colleagues in Clinical Pharmacology and Pharmacometrics to develop end-to-end alignment in model-informed drug development (MIDD) plans and to collectively advance the science and impact of mechanistic modeling and simulation.
• Network as appropriate with global experts in the department and other groups to share learnings and enhance consistency in best practices across sites, disease areas, and interventionalmodalities.
• Keep up to date with emerging literature in the area of mechanistic modeling and simulation sciences.
• Continue to build a personal track record of publication in the area of PK/PD modeling and simulation and contribute to PDM’s external publication/presentation goals consistent with our sustained investments in the area of modeling and simulation.

Here Is What You Need (Minimum Requirements)

• Ph.D. degree or equivalent degree in systems biology, pharmacometrics, pharmaceutical sciences, engineering, physics, mathematics, or similar disciplines where modeling and simulation is emphasized; experience with modeling of biological systems is strongly preferred.
• 0 – 2 years of relevant experience in the pharmaceutical industry.
• Strong communication skills, ability to work independently and in teams, and attention to detail.
• Good team player and communicator; including good listening skills and the ability to effectively interact with colleagues with a variety of backgrounds.
• Self-starter with demonstrated ability to work in a small team with minimal technical supervision.
• Excellent understanding of theory, principles, and statistical aspects of advanced mathematical modeling and simulation.
• Ability to translate/condense/summarize outcomes of modeling and simulation analyses into information that can be understood by non-experts.
• Hands-on knowledge of the state-of-the-art modeling and simulation software and applications in the area of PK/PD modeling and simulation (e.g. NONMEM, MatLab, Phoenix, Berkeley-Madonna, SAAM II, ADAPT, ACSL, S-plus, R or comparable applications).
• An understanding of the basic principles of pharmacokinetics (e.g. non-compartmental, compartmental, PBPK).
• Ability to learn new areas of biological sciences and build on solid foundation of quantitative skills to develop mechanistically-relevant PK/PD models.
• Ability to keep up-to-date with and propose the implementation of scientific and technological developments in the area of PK/PD modeling and simulation.
• Motivation to develop a career as a hands-on, technical modeling and simulation expert in a preclinical drug discovery environment.
• Keen to interact as a modeling and simulation experts with matrix project teams working closely with PDM, Biology, and Clinical scientists.
• Strong belief that modeling and simulation can have a significant positive impact on research projects.
• Commitment to the development of self and others.
• Motivation to share technical expertise with others.

Bonus Points If You Have (Preferred Requirements)

• Familiarity with the phases of drug discovery and development, with particular emphasis in the area of translational research, is helpful but not required.
• Experience with quantiative mechanistic modeling of the pharmacokinetic and PKPD behavior of biologics preferred.

• Experience in clinical pharmacology and/or pharmacometrics

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

Occasional travel, 1-2 times a year, may be needed.

Relocation support available

Work Location Assignment:Hybrid

The annual base salary for this position ranges from $90,900.00 to $151,500.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

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