Senior Scientist, Translational Development

Bristol-Myers Squibb; United States; Hybrid; USD 142,000 - 172,000; Full time

Job summary

Bristol Myers Squibb in Cambridge, MA is seeking a scientist to manage the preclinical laboratory components of immune-oncology programs (phase 2 and beyond). Reporting to the Director of Translational Development, you will lead mechanism-of-action studies and differentiation from standard care molecules.

This full-time, hybrid role requires a PhD with relevant experience, strong publication record, and ability to collaborate across teams.

Qualifications

• PhD with at least 2 years of relevant work experience in immune-oncology, hematology and/or immunology.
• Excellent publication record in high tier scientific journals and strong research track record in academic or industry setting, leading innovative efforts within the laboratory to achieve defined goals and support clinical development.

Responsibilities

• Performs preclinical/laboratory studies involving late-stage BMS assets to support annual goals and objectives for the Translational Medicine research group
• Responsible for delivering data in support of translational strategies including biomarkers, patient selection hypotheses, dose and schedule, combination strategies, resistance mechanisms and differentiation
• Interfaces with other research scientists within and outside of Translational Medicine to ensure seamless flow of information
• May contribute to external preclinical collaborations across the clinical asset pipeline
• Accurately maintain written reports and present results in an organized and timely manner
• Communicate effectively, foster teamwork and contribute to project strategy discussions

Skills

Flow cytometry

Cell sorting

Immune-oncology

Data analysis

Scientific writing

Project management

Education

PhD in a relevant field

Tools

Akoya

Visium

Job description

At Bristol Myers Squibb, our employees often ask, \"Who are you working for?\"-a question that fuels collaboration, accountability, and urgency in our work. Our purpose-driven culture inspires us to discover, develop, and deliver innovative medicines to prevail over serious diseases. We offer uniquely interesting and meaningful work, opportunities for growth, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits. This is work that transforms the lives of patients, and the careers of those who do it.

Translational Development at BMS

Translational Development is part of the Global Research organization in BMS and leads late-stage clinical, pharmacological and translational research and development activities for the pipeline and supports late-stage portfolio for regulatory, translational development and life cycle management. Translational Development drives strategy across core therapeutic areas at BMS including hematology, oncology, immunology, cardiovascular and neuroscience. This group integrates laboratory science, clinical trial/biomarkers and asset development as well as disease research to maximize the potential of BMS current and future therapeutics.

Position Summary

Reporting to Director/Translational Development, the new role will be part of the translational group based in Cambridge, MA and will manage the scientific and preclinical laboratory component of multiple immune-oncology interfacing late-stage programs (phase 2 and beyond). Key responsibilities of this role are to lead from the bench supporting programs through mechanism of action-based studies, differentiation from standard of care molecules, combination rationale and resistance mechanisms.

Key Responsibilities

• Performs preclinical/laboratory studies involving late-stage BMS assets to support annual goals and objectives for the Translational Medicine research group
• Responsible for delivering data in support of translational strategies including biomarkers, patient selection hypotheses, dose and schedule, combination strategies, resistance mechanisms and differentiation
• Interfaces with other research scientists within and outside of Translational Medicine to ensure seamless flow of information
• May contribute to external preclinical collaborations across the clinical asset pipeline
• Accurately maintain written reports and present results in an organized and timely manner
• Communicate effectively, foster teamwork and contribute to project strategy discussions

Qualifications & Experience

• PhD with at least 2 years of relevant work experience in an academic or industry setting focusing on immune-oncology, hematology and/or immunology
• Excellent publication record in high tier scientific journals and strong research track record in academic or industry setting, leading innovative efforts within the laboratory to achieve defined goals and support clinical development

Technical Skills

• In vitro : Multi-parameter flow cytometry and cell sorting in the context of primary immune cell characterization, cellular based immune effector assays (ADCC, ADCP, T-cell killing), cytokine analysis (ELISA/MSD), bulk/sc-RNA-seq.
• In vivo : end-to-end syngeneic and CDX-based efficacy studies (i.v./p.o.), tumor immunophenotyping and transcriptomic profiling
• Experience with spatial technology platforms (e.g. Akoya, Visium, COSMX or similar) a plus.
• Ability to work with disease teams/experts to develop preclinical strategies to support clinical development and life cycle management
• Strong verbal and written communication skills with experience in developing written documents such as primary manuscripts/publications are essential
• Strong commitment to quality, integrity, accountability and demonstrated adaptability
• Excellent communication, managerial and scientific qualities are expected
• High competency in scientific analysis, innovative solutions and the ability to strategically prioritize goals.

#LI-Hybrid

#LI-Hybrid

Compensation Overview

Cambridge Crossing: $142,220 - $172,340

The starting pay range(s) listed above is for full-time employees (FTE). You may also be eligible for additional discretionary incentive cash and stock opportunities. We determine starting pay thoughtfully - carefully considering the nature of the role, required skills, work location, schedule and the knowledge and experience you bring. Final compensation is guided by pay equity principles and applicable employment laws. Compensation programs are reviewed on an ongoing basis and may be adjusted over time to reflect evolving market factors, and individual, team or Company performance.

Benefits

Subject to the terms and conditions of the applicable plans then in effect, you may be eligible to participate in our comprehensive benefit plans - including wellbeing support, retirem