Senior Scientist, Systems Toxicology & Multi-Omics

Sanofi Group; Cambridge (MA); On-site; USD 179,000 - 258,000; Full time

Benefits offered by this job

High-quality healthcare

Prevention and wellness programs

14 weeks gender-neutral parental leave

Job summary

Sanofi in Cambridge, MA invites a Distinguished Scientist, Systems Toxicology to provide scientific leadership in applying multi-omics and systems biology to predict safety liabilities and mechanisms of toxicity, guiding experiments and informing development decisions.

You will lead cross-disciplinary analyses, mentor scientists, establish robust analytical workflows, and partner with project toxicologists and scientific advisors to translate biology into actionable insights across preclinical

Qualifications

• MS plus 8 years experience or PhD plus 5 years experience.
• Scientific expertise: Systems Biology, Computational Biology, Bioinformatics, or a related discipline, with extensive research experience and demonstrated independent leadership of complex investigations.
• Technical skills: Deep hands-on expertise in transcriptomics and demonstrated experience integrating multiple molecular or phenotypic data types.
• Computational and statistical capabilities: Strong proficiency in R and/or Python and relevant bioinformatics tools.
• Mechanistic and translational interpretation: Expertise in pathway and network analysis, molecular signatures, and hypothesis generation.
• Drug discovery and safety experience: Substantial experience applying systems approaches to toxicology, safety assessment, or closely related mechanistic research in pharmaceutical or biotechnology settings.
• Strategic mindset: Understanding of how preclinical safety data translates to human safety, ability to translate scientific vision into actionable roadmaps, connect digital toxicology to broader R&D strategy.
• Communication & influence: Ability to communicate complex analyses clearly to experimental scientists, computational specialists, project teams, and senior leaders.

Responsibilities

• Provide scientific direction for systems toxicology, defining approaches for applying omics and integrative biology to priority safety questions.
• Lead integrated analyses of complex biological datasets, connecting transcriptomics with complementary data such as proteomics, metabolomics, imaging, pathology, and functional assays.
• Generate and prioritize mechanistic hypotheses using pathway analysis, network biology, molecular signatures, and existing biological knowledge.
• Establish reproducible and scalable analytical workflows, spanning data processing, quality assessment, statistical analysis, visualization, and reporting.
• Drive cross-functional investigations across Preclinical Safety, connecting early screening, complex models, and investigative studies with molecular mechanisms.
• Provide scientific leadership across project teams and global functions, working with project toxicologists and scientific advisors to define decision-relevant questions and communicate integrated findings.
• Demonstrate scientific and portfolio impact, serving as a scientific authority and mentor across the global organization.

Skills

Systems Biology

Computational Biology

Bioinformatics

Transcriptomics

Pathway analysis

Network biology

R

Python

Data integration

Education

MS + 8 years experience or PhD + 5 years experience

Job description

Sanofi in Cambridge, MA invites a Distinguished Scientist, Systems Toxicology to provide scientific leadership in applying multi-omics and systems biology to predict safety liabilities and mechanisms of toxicity, guiding experiments and informing development decisions.

You will lead cross-disciplinary analyses, mentor scientists, establish robust analytical workflows, and partner with project toxicologists and scientific advisors to translate biology into actionable insights across preclinical