Senior Scientist, Synthetic Purification (On-site)

Merck; New Jersey; On-site; USD 117,000 - 184,000; Full time

Job summary

Merck in Rahway, NJ, is seeking a Senior Scientist to lead chromatographic isolation from analytical to prep scale across small molecules and biologics within the Separations Sciences team. You will partner with process chemists and analytical scientists to deploy efficient purification workflows and to deliver high-purity materials.

The role emphasizes collaborative problem solving, rigorous analytical work, and effective scientific communication as part of advancing our development pipeline in

Qualifications

• Ph.D. in Synthetic, Natural product, Analytical Chemistry or related field.
• MS with 5+ years in biopharma.

Responsibilities

• Lead chromatographic isolation from analytical to prep scale.
• Collaborate with process chemists and analytical scientists on purification workflows.
• Deliver high-purity materials across small molecules and biologics.

Skills

Analytical Chemistry

Method Development

Assay Development

Chromatography

Mass Spectrometry

UPLC

Biopharmaceuticals

Purification Methods

Education

Ph.D. in Chemistry or related field

M.S. with 5+ years biopharma experience

Tools

MS Instruments

Analytical Detectors

Job description

Job Description

Our Research Scientists are our Inventors. We identify and target steps in disease mechanisms or pathways that could be inhibited or enhanced. Our goal is to use innovative thinking, state-of-the-art facilities, and robust scientific methodology, we collaborate to discover the next medical breakthrough.

As a Senior Scientist in the multiscale separations team within the Separations Sciences team of Analytical Enabling Capabilities, you will work within a highly collaborative team to enable the advancement of the development pipeline. You will be primarily responsible for chromatographic isolation of pharmaceutical API and impurities from analytical scale to semi-prep scale and prep scale, covering the space of small molecules, peptides, conjugate-based modalities as well as emerging modalities in our portfolio. To accelerate the development of new medicines and vaccines, you will partner with process chemists and analytical scientists to deploy efficient and fit-for-purpose chemical isolation methods, to establish innovative purification workflows, and to deliver high purity materials. As a member of our team, you will be joining a diverse group of scientific problem solvers, who are dedicated to creating the life-changing products of tomorrow.

Education Minimum Requirements

Ph.D. in Synthetic Chemistry, Natural product chemistry, Analytical Chemistry or a related field. M.S. with a minimum of 5 years of experience in the Biopharmaceutical industry.

Required Experience and Skills

• Experience in analytical, semi-prep/prep scale chromatography (RPLC, NPLC, SFC), technologies, instrumentation, and workflows, with demonstrated experience in its applications in chiral, achiral isolation of challenging pharmaceutical mixtures to support a variety of pharmaceutical modalities including small molecules, peptides, antibody-drug conjugates and vaccines adjuvants etc.
• Experience in mass spectrometry and its application in MS-directed chromatographic purification.
• Working knowledge of orthogonal detection technologies, including PDA, Multi-angle light scattering, charged aerosol detection etc.
• Creative problem solving in scientific research and development, with proven track-record of translating R&D problem solving into impactful pipeline deliveries.
• External scientific engagement that may include a combination of publications, industry white paper contributions, presentations at scientific meetings.
• Excellent scientific writing and verbal communication skills.

Preferred Experience and Skills

• Experience working in the bio-pharmaceutical industry as Postdoc or intern is preferred.

Required Skills

Analytical Chemistry, Analytical Method Development, Assay Development, Biopharmaceuticals, Chemical Synthesis, Chemistry, Chromatography, Mass Spectrometry (MS), Method Development, Purification Methods, Small Molecules, Synthetic Chemistry, Synthetic Organic Chemistry, Technical Writing, Ultra Performance Liquid Chromatography (UPLC)

US and Puerto Rico Residents Only

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As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.

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The primary location for this posting is

USA - New Jersey - Rahway

Where required by law, the compensation range for this role is provided below.

The salary range for the primary location of this role is

$117,000.00 - $184,200.00

This range reflects the Company's reasonable expectation of the base salary applicable to this role at the time of posting. An employee's position within the salary range will be based on several factors including, but not limited to re