Senior Scientist, Small Molecule Synthesis & SAR

Scorpion Therapeutics; Town of Mount Pleasant (NY); On-site; USD 120,000 - 180,000; Full time

Job summary

Scorpion Therapeutics in New York, NY, is seeking a senior medicinal chemist to lead small-molecule synthesis programs. You will execute multistep syntheses, isolate and characterize compounds, and interpret spectroscopic data to confirm structures.

You’ll troubleshoot data, propose new synthetic routes, and shape SAR directions while collaborating with cross-functional teams to advance the company’s drug discovery pipeline.

Qualifications

• MSc. in synthetic organic chemistry (or related).
• Familiarity with drug discovery processes and modern methods in synthetic organic and medicinal chemistry.
• 5–7+ years of industry drug discovery experience with small molecules (required).
• Retrosynthetic analysis and synthetic route design experience.
• Hands-on execution of multistep synthetic protocols.
• Strong understanding of modern organic synthesis strategies and techniques; ability to work independently with a fit-for-purpose approach.
• Ability to interpret spectroscopic data for small-molecule structure assignment/confirmation (required).

Responsibilities

• Perform day-to-day laboratory activities for small-molecule syntheses, including isolation and characterization.
• Troubleshoot, analyze data, interpret results, and propose synthetic approaches.
• Discuss biological data and targets to support SAR directions.
• Identify new strategies/technologies for synthetic execution of targets.
• Work with cross-functional and supervisor priorities to ensure progression of technology and pipeline projects.
• Attend departmental/cross-functional meetings to contribute expertise.
• Interact collaboratively with other company groups.

Skills

MSc in synthesis

Drug discovery experience

Retrosynthesis planning

Spectroscopic analysis

Independent work

SAR discussion

Antibody conjugates

Education

MSc in synthetic organic chemistry

Job description

Scorpion Therapeutics in New York, NY, is seeking a senior medicinal chemist to lead small-molecule synthesis programs. You will execute multistep syntheses, isolate and characterize compounds, and interpret spectroscopic data to confirm structures.

You’ll troubleshoot data, propose new synthetic routes, and shape SAR directions while collaborating with cross-functional teams to advance the company’s drug discovery pipeline.