Senior Scientist- Proteogenomics Approaches for Novel Antigen Discovery

Regeneron; Village of Tarrytown (NY); On-site; USD 90,000 - 130,000; Full time

Job summary

A leading company in the biotechnology sector is seeking a Senior Scientist specializing in proteogenomics. The ideal candidate will leverage advanced mass spectrometry techniques to discover disease-specific antigens and contribute to innovative immunotherapeutics. This role requires a Ph.D. or equivalent experience and offers a dynamic research environment with comprehensive benefits.

Benefits

Health Programs

Fitness Centers

Bonuses

Paid Time Off

Qualifications

• Ph.D. with 0-3 years of experience or BS/MS with 8-10+ years.
• Experience operating HPLC and mass spectrometers.

Responsibilities

• Running mass spectrometry data analysis.
• Method development and optimization, including automation.
• Collaborating across scientific disciplines.

Skills

Organizational Skills

Problem-Solving

Data Analysis

Education

Ph.D. in biology, biochemistry, biotechnology, or related field

BS/MS

Tools

HPLC

LC-MS

Xcalibur

PEAKS

Spectronaut

FragPipe

Skyline

Job description

Join to apply for the Senior Scientist - Proteogenomics Approaches for Novel Antigen Discovery role at Regeneron.

We are seeking a highly motivated Senior Scientist who will utilize our advanced facilities and technology to perform qualitative and quantitative mass spectrometry experiments targeting autoimmune, infectious disease, and oncology for novel immunotherapeutics such as bispecific antibodies, cell therapies, and vaccines. The role involves applying cutting-edge mass spectrometry techniques for discovering and validating disease-specific antigens from human tissues and cell lines, as well as developing innovative methods to enhance target discovery.

Responsibilities include:

• Running mass spectrometry data analysis (total proteomics, cell surface proteomics, immunopeptidomics)
• Method development and optimization, including automation
• Preparing MS samples from various normal, diseased, and tumor tissues, including pre-fractionation and digestion
• Affinity purification of proteins/peptides from diverse samples
• Collaborating across scientific disciplines to design and perform analyses
• Presenting data and findings internally and externally, and preparing conference and publication materials

Ideal candidates will have:

• Strong organizational skills and attention to detail
• Ability to work effectively in a fast-paced environment
• Self-motivation and independence, with team collaboration skills
• Strategic thinking and problem-solving abilities
• Excellent prioritization and multitasking skills

Minimum qualifications:

• Ph.D. in biology, biochemistry, biotechnology, or related field with 0-3 years of experience, or BS/MS with 8-10+ years
• Experience operating HPLC and mass spectrometers (LC-MS)
• Preferred experience with Thermo Orbitrap or Bruker Ultra series mass spectrometers
• Knowledge of autoimmunity and immunology is desirable
• Experience with immunoprecipitation sample prep for MS analysis
• Data analysis skills using tools like Xcalibur, PEAKS, Spectronaut, FragPipe, Skyline, and database search engines
• Immunopeptidomics experience and large-scale NGS data analysis are pluses

Apply now to join Regeneron and contribute to innovative research in a diverse and inclusive environment. We offer comprehensive benefits, including health programs, fitness centers, bonuses, and paid time off.