Senior Scientist/Principal Scientist- Biotransformation/Met ID

ZipRecruiter; Exton (Chester County); On-site; USD 90,000 - 120,000; Full time

Job summary

A leading company in Chester County is seeking a Senior Scientist specializing in Biotransformation and Metabolite Identification. The role involves characterizing drug metabolites and ensuring compliance with industry standards. Ideal candidates will have a Ph.D. and strong analytical skills, contributing to drug safety and efficacy.

Benefits

Competitive salary and benefits package

Opportunities for professional growth

Collaborative work environment

Qualifications

• Ph.D. required in relevant scientific fields.
• Expertise in drug metabolism and biotransformation.

Responsibilities

• Design and execute biotransformation studies.
• Prepare scientific reports and regulatory documents.
• Interact with clients to provide insights.

Skills

Drug Metabolism

Biotransformation

Mass Spectrometry

Analytical Techniques

Communication

Education

Ph.D. in Chemistry

Ph.D. in Biochemistry

Ph.D. in Pharmaceutical Sciences

Tools

LC-MS/MS

HRMS

Thermo Orbitrap

Waters Q-TOF

Job description

Job Description

Job Title: Senior Scientist / Principal Scientist – Biotransformation/Metabolite Identification

Location: Exton, Pennsylvania

Full-time

Job Description:
We are seeking a highly motivated and experienced Senior Scientist specializing in Biotransformation and Metabolite Identification to join our dynamic team. This individual will play a pivotal role in the characterization and identification of drug metabolites, contributing to our understanding of drug metabolism and its impact on drug safety and efficacy.

Key Responsibilities:

• Design, execute, and interpret biotransformation studies to characterize drug metabolites in vitro and in vivo.
• Develop and optimize sample preparation and analytical techniques for metabolite profiling and identification using state-of-the-art LC-MS/MS and high-resolution mass spectrometry (HRMS).
• Interact with clients to provide actionable insights on metabolism-related challenges.
• Prepare and review scientific reports, presentations, and regulatory documents to ensure accuracy and compliance with industry standards.
• Stay updated on advancements in biotransformation and metabolite identification technologies and methodologies.

Qualifications:

• Ph.D. in Chemistry, Biochemistry, Pharmaceutical Sciences, or a related field.
• Strong expertise in drug metabolism and biotransformation, with hands-on experience in metabolite identification using LC-MS/MS and HRMS.
• Knowledge of in vitro (e.g., hepatocytes, microsomes) and in vivo systems for studying drug metabolism.
• Familiarity with regulatory guidelines (e.g., FDA, EMA) for metabolite safety testing (MIST).
• Demonstrated ability to analyze and interpret complex mass spectrometry data and provide detailed reports.
• Excellent communication skills and ability to work collaboratively in a cross-functional team environment.

Skills:

• Experience with radiolabeled compounds and metabolite profiling.
• Track record of publications or presentations in the field of drug metabolism or biotransformation.
• Hands-on experience with Thermo Orbitrap or Waters Q-TOF mass spectrometers.

What We Offer:

• Competitive salary and benefits package.
• Opportunities for professional growth and development.
• A collaborative and innovative work environment.

Frontage Laboratories Inc. is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, or protected veteran status.