Senior Scientist, Multispecific Antibody Engineering

Johnson & Johnson; Gwynedd (PA); On-site; USD 90,000 - 150,000; Full time

Job summary

An established industry player is seeking a Senior Scientist in Multispecific Antibody Engineering to join their innovative team. This role offers the opportunity to engage in the discovery and molecular engineering of biotherapeutics, focusing on the design and development of multispecific antibodies. As a key member of the team, you will lead project initiatives and collaborate with world-class scientists, utilizing cutting-edge technology to drive therapeutic design. If you are passionate about advancing scientific knowledge and thrive in a collaborative environment, this position is perfect for you.

Qualifications

• Ph.D. in structural biology, biochemistry, or biophysics with 2+ years of experience required.
• In-depth knowledge of protein structure analysis and design methods is essential.

Responsibilities

• Lead project teams to advance discovery portfolio projects.
• Independently present scientific findings in multi-functional teams.

Skills

Protein Structure Analysis

Protein Design

Biophysical Methods

Biochemical Methods

Molecular Biology

Scientific Communication

Creative Problem Solving

Education

Ph.D. in Structural Biology

Post-Ph.D. Experience

Tools

Schrodinger

MOE

PyMol

Chimera

Python

Job description

Job Description - Senior Scientist, Multispecific Antibody Engineering (2406227658W)

Senior Scientist, Multispecific Antibody Engineering - 2406227658W

Description

Johnson & Johnson is recruiting for a Senior Scientist, Multispecific Antibody Engineering located in Spring House, PA.

The Protein Engineering and In Vitro Discovery Team within Biologics Discovery is responsible for the design of lead biologic candidates. In this position, the Senior Scientist will be an integral member of the Multispecific Antibody Engineering Group that works on the cutting edge of technology to deliver “therapeutic design fit-for-purpose” into the pipeline. The position offers an exciting opportunity to not only engage in the discovery and molecular engineering of biotherapeutics, but also develop new processes and technologies. This role is focused on the design and development of multispecific antibodies. This Senior Scientist will have the opportunity to lead project teams and interact seamlessly with world-class Therapeutic Area scientists.

Key Responsibilities:

• Lead/participate on project teams to advance discovery portfolio projects.
• Champion cross-functional technology development efforts aimed at fulfilling strategic long-term antibody design initiatives and validation.
• Independently present/defend scientific findings in multi-functional project teams/initiatives.
• Independently plan, analyze and interpret experimental results and draft patent applications, manuscripts, protocols, SOPs, technical reports, etc.

Qualifications

Education:

• Minimum of Ph. D. in structural biology, biochemistry, or biophysics with a minimum 2 years of experience post-Ph. D. is required.

Experience and Skills:

Required:

• In-depth knowledge and demonstrated experience in protein structure and analysis, including structure determination methods (e.g. x-ray crystallography, cryo-electron microscopy, NMR) and structure-based protein design is required.
• Sound understanding of biophysical and biochemical methods for protein analysis, including ELISA, SPR, and/or flow cytometry, thermal stability analysis, and protein expression/purification from mammalian and bacterial cells is required.
• Expertise in protein structure modeling and analysis (e.g. Schrodinger, MOE, pyMol, Chimera, etc.) is required.
• Detailed knowledge of molecular biology, including expression vector design, protein expression from mammalian host cells and purification (affinity chromatography, ion-exchange chromatography, etc) is required.
• Zeal for addressing complex scientific questions with creativity and a collaborative spirit. Demonstration of successful implementation of new ideas with calculated risk taking. Abilities to lead by influence and communicate across teams with diverse backgrounds is required.
• Demonstration of clear, concise, and timely communication skills, exemplified by peer-reviewed publications is required.

Preferred:

• A minimum of 1 year of industry experience is preferred.
• Expertise in scientific computing (e.g. Python) and knowledge of in silico protein structure analysis is highly preferred.
• Detailed understanding of antibody sequence analysis, including post-translational modification risks, germline analysis, and Fc-mediated effector functions is preferred.
• Experience with of the state-of-the-art molecular biology and protein engineering methods, including antibody and cytokine is preferred.
• Understanding of antibody and cytokine structure and function, including modulation of target binding and Fc-based effector function is preferred.
• Hands on experience in HTP-based binding assays (such as ELISA, SPR, MSD) and/or cell-based (Intellicyt/iQue) for screening antibody variants is preferred.