Senior Scientist, Mass Spectrometry

BeiGene Ltd.; San Carlos (CA); On-site; USD 150,000 - 188,000; Full time

Benefits offered by this job

Medical

Dental

Vision

401(k)

FSA/HSA

Life Insurance

Paid Time Off

Wellness

Job summary

BeOne Institute is seeking a Senior Scientist in San Carlos, CA to advance cutting-edge research using advanced mass spectrometry. You will uncover biological insights, enable new therapeutic modalities, and develop screening and characterization methods for drug discovery.

Collaboration across biology, chemistry, and technology will drive discovery and platform development. You will design MS-based studies, optimize workflows, and maintain robust data while contributing to multidisciplinary

Qualifications

• Ph.D. strongly preferred and 2+ years (Ph.D.), 4+ years (M.S.), or 5+ years (B.S.) of relevant experience.
• Hands-on experience operating, troubleshooting, and optimizing LC-MS instrumentation.
• Experience developing MS‑based analytical or proteomics workflows.
• Experience applying MS approaches to address biological questions in drug discovery.
• Experience with quantitative proteomics and MS-based methods.

Responsibilities

• Contribute creatively to Institute research by generating ideas and advancing innovative projects.
• Design and execute MS-based studies to address biological questions and support drug discovery.
• Develop, optimize, and apply MS-based screening, proteomics, and analytical workflows.
• Evaluate new MS technologies and apply them to enhance capabilities.
• Operate, maintain, troubleshoot MS platforms and ensure high-quality data.
• Analyze, interpret, and communicate MS data with biological insights for projects.
• Collaborate with biology, chemistry, and related disciplines on analytical approaches.
• Maintain high-quality experimental records and stay current with MS advances.

Skills

Mass spectrometry

LC-MS instrumentation

Data analysis

Proteomics

Education

Ph.D., M.S., or B.S. in Analytical Chemistry/Biochemistry/Biology/Chemistry

Tools

Orbitrap systems

Q-TOF

Mass spectrometry software

Job description

General Description

At BeOne Institute, we extend BeOne’s execution strength with a dedicated innovation engine, bringing agility and scientific depth to transform uncertainty into actionable and high-impact therapeutic opportunities.

We operate according to three core principles:

Bold Exploration: we pursue novel and high-potential ideas through rapid, iterative innovation cycles.

Strategic Alignment: we prioritize disease areas that align closely with BeOne’s R&D priorities and long‑term vision.

Pipeline Impact: we translate insights into tangible assets and advance emerging platforms into impactful programs.

Senior Scientist Role

As a Senior Scientist at BeOne Institute, you will play an important role in advancing cutting‑edge research at our San Carlos, CA site. You will apply advanced mass spectrometry technologies to uncover novel biological insights, enable emerging therapeutic modalities, and develop innovative screening and characterization approaches for drug discovery. Working at the interface of biology, chemistry, and technology development, you will collaborate with multidisciplinary teams to address challenging scientific questions, develop new analytical capabilities, and generate insights that can inform future therapeutic opportunities. This is a unique opportunity to pursue bold ideas and translate them into real medicines!

Essential Functions of the Job

• Contribute creatively to Institute research by generating ideas, challenging assumptions, and advancing innovative scientific projects.
• Design and execute mass spectrometry‑based studies to address biological questions, support emerging therapeutic modalities, and enable drug discovery research.
• Develop, optimize, and apply mass spectrometry‑based screening, proteomics, and analytical workflows to support compound discovery, target identification, target engagement, mechanism‑of‑action studies, and pathway biology.
• Evaluate and implement new mass spectrometry technologies, workflows, and applications to enhance scientific and technical capabilities.
• Operate, maintain, troubleshoot, and continuously improve mass spectrometry platforms to ensure robust analytical performance and high‑quality data generation.
• Analyze, interpret, and communicate mass spectrometry data, translating analytical results into meaningful biological and drug discovery insights.
• Collaborate closely with scientists across biology, chemistry, and related disciplines to develop fit‑for‑purpose analytical approaches and support multidisciplinary research efforts.
• Maintain high‑quality experimental records and documentation, and stay current with advances in mass spectrometry, analytical technologies, and related scientific fields.

Supervisory Responsibilities

• May be a contact for external CRO partners when needed
• May provide matrix or line‑function leadership for project teams when needed
• undefined

Computer Skills

• Proficiency with mass spectrometry data acquisition, processing, and analysis software
• Strong computational and data analysis skills, including experience analyzing complex quantitative mass spectrometry datasets
• Experience with software and tools for MS‑based screening and assay development

Required Qualifications

• Ph.D., M.S., or B.S. degree in Analytical Chemistry, Biochemistry, Biology, Chemistry, Pharmaceutical Sciences, or a related scientific discipline, and 2+ years (Ph.D.), 4+ years (M.S.), or 5+ years (B.S.) of relevant industry, academic, or postdoctoral experience. Ph.D. strongly preferred.
• Strong foundation in mass spectrometry, with hands‑on experience operating, troubleshooting, and optimizing LC‑MS instrumentation.
• Experience developing and implementing mass spectrometry‑based analytical, screening, and/or proteomics workflows.
• Demonstrated ability to apply mass spectrometry approaches to address biological questions and support drug discovery research.
• Experience with quantitative proteomics and/or other MS‑based approaches for protein identification, characterization, interaction analysis, or pathway interrogation.Experience developing and optimizing sample preparation, chromatography, and mass spectrometry methods for biological applications.
• Strong data analysis and interpretation skills, with the ability to derive meaningful conclusions from complex mass spectrometry datasets.
• Ability to troubleshoot analytical challenges and contribute creative solutions to technical and scientific problems.
• Ability to collaborate effectively with scientists across biology, chemistry, and related disciplines to develop fit‑for‑purpose analytical approaches.
• Strong written, verbal, and presentation skills, with the ability to communicate scientific findings to multidisciplinary teams.
• Ability to work on‑site in San Carlos, CA.

Preferred Qualifications

• E xperience with Orbitrap systems (Astral a plus) and/or Agilent Q‑TOFs
• Knowledge of cancer pathways.
• Experience with ASMS and APMS workflows (in a drug discovery setting a plus)

Travel: None

Global Competencies

• Fosters Teamwork
• Provides and Solicits Honest and Actionable Feedback
• Self‑Awareness
• Acts Inclusively
• Demonstrates Initiative
• Entrepreneurial Mindset
• Continuous Learning
• Embraces Change
• Results‑Oriented
• Analytical Thinking/Data Analysis
• Financial Excellence
• Communicates with Clarity

Salary Range: $150,200.00 - $187,800.00 annually

BeOne is committed to fair and equitable compensation practices. Actual compensation packages are determined by several factors that are unique to each candidate, including but not limited to job‑related skills, depth of experience, certifications, relevant education or training, and specific work location. Packages may vary by location due to differences in the cost of labor. The recruiter can share more about the specific salary range for a preferred location during the hiring process. Please note that the listed range reflects the base salary or hourly range only. Non‑Commercial roles are eligible to participate in the annual bonus plan, and Commercial roles are eligible to participate in an incentive compensation plan. All Company employees have the opportunity to own shares of BeOne Medicines Ltd. stock because all employees are eligible for discretionary equity awards and to voluntarily participate in the Employee Stock Purchase Plan.

The Company has a comprehensive benefits package that includes

• Medical
• Dental
• Vision
• 401(k)
• FSA/HSA
• Life Insurance
• Paid Time Off
• Wellness

We are proud to be an equal opportunity employer. BeOne does not discriminate on the basis of race, religion, color, sex, gender identity, sexual orientation, age, disability, national origin, veteran status or any other basis covered by appropriate law. All employment is decided on the basis of qualifications, merit, and business need.

In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans’ Readjustment Assistance Act of 1974, Title I of the Americans with Disabilities Act of 1990, and any other applicable federal, state or local laws, applicants who require reasonable accommodation in the job application process may contact [e-mail] .