Senior Scientist, Mass Spectrometry

BeiGene, Ltd.; San Carlos (CA); On-site; USD 150,000 - 188,000; Full time

Benefits offered by this job

Medical

Dental

Vision

401(k)

FSA/HSA

Life Insurance

Paid Time Off

Wellness

Job summary

BeOne Medicines Ltd. in San Carlos, CA, is seeking a Senior Scientist to advance cutting-edge mass spectrometry-driven research for drug discovery at the BeOne Institute. You will collaborate across biology, chemistry, and tech teams, applying advanced MS to uncover insights and enable novel therapeutic modalities.

The role emphasizes developing screening and analytical workflows, evaluating new MS technologies, and producing high-quality data while working on-site in San Carlos, CA.

Qualifications

• Ph.D., M.S., or B.S. degree in Analytical Chemistry, Biochemistry, Biology, Chemistry, Pharmaceutical Sciences, or a related scientific discipline, with 2+ years (Ph.D.), 4+ years (M.S.), or 5+ years (B.S.) of relevant industry, academic, or postdoctoral experience.
• Strong foundation in mass spectrometry with hands-on LC-MS operation, troubleshooting, and optimization.
• Experience developing MS-based analytical, screening, and/or proteomics workflows.
• Proven ability to apply MS approaches to address biological questions and support drug discovery.

Responsibilities

• Contribute creatively to Institute research by generating ideas and advancing innovative scientific projects.
• Design and execute mass spectrometry-based studies to address biological questions and enable drug discovery.
• Develop, optimize, and apply MS-based screening and proteomics workflows for discovery pipelines.
• Evaluate and implement new MS technologies and workflows to enhance capabilities.
• Operate, maintain, troubleshoot, and improve MS platforms for robust data generation.
• Communicate MS data and insights to multidisciplinary teams.

Skills

Mass spectrometry

LC-MS

Proteomics

Data analysis

Analytical methods

Scientific collaboration

Scientific communication

Education

Ph.D./M.S./B.S. in Analytical Chemistry, Biochemistry, Biology, Chemistry, Pharmaceutical Sciences, or related field

Tools

Orbitrap systems

Q-TOF instruments

MS software and data processing tools

Job description

BeOne continues to grow at a rapid pace with challenging and exciting opportunities for experienced professionals. When considering candidates, we look for scientific and business professionals who are highly motivated, collaborative, and most importantly, share our passionate interest in fighting cancer.

General Description

At BeOne Institute, we extend BeOne's execution strength with a dedicated innovation engine, bringing agility and scientific depth to transform uncertainty into actionable and high-impact therapeutic opportunities. We operate according to three core principles: Bold Exploration: we pursue novel and high-potential ideas through rapid, iterative innovation cycles. Strategic Alignment: we prioritize disease areas that align closely with BeOne's R&D priorities and long-term vision. Pipeline Impact: we translate insights into tangible assets and advance emerging platforms into impactful programs.

As a Senior Scientist at BeOne Institute, you will play an important role in advancing cutting-edge research at our San Carlos, CA site. You will apply advanced mass spectrometry technologies to uncover novel biological insights, enable emerging therapeutic modalities, and develop innovative screening and characterization approaches for drug discovery. Working at the interface of biology, chemistry, and technology development, you will collaborate with multidisciplinary teams to address challenging scientific questions, develop new analytical capabilities, and generate insights that can inform future therapeutic opportunities. This is a unique opportunity to pursue bold ideas and translate them into real medicines!

Essential Functions of the Job

• Contribute creatively to Institute research by generating ideas, challenging assumptions, and advancing innovative scientific projects.
• Design and execute mass spectrometry-based studies to address biological questions, support emerging therapeutic modalities, and enable drug discovery research.
• Develop, optimize, and apply mass spectrometry-based screening, proteomics, and analytical workflows to support compound discovery, target identification, target engagement, mechanism-of-action studies, and pathway biology.
• Evaluate and implement new mass spectrometry technologies, workflows, and applications to enhance scientific and technical capabilities.
• Operate, maintain, troubleshoot, and continuously improve mass spectrometry platforms to ensure robust analytical performance and high-quality data generation.
• Analyze, interpret, and communicate mass spectrometry data, translating analytical results into meaningful biological and drug discovery insights.
• Collaborate closely with scientists across biology, chemistry, and related disciplines to develop fit-for-purpose analytical approaches and support multidisciplinary research efforts.
• Maintain high-quality experimental records and documentation, and stay current with advances in mass spectrometry, analytical technologies, and related scientific fields.

Supervisory Responsibilities: May be a contact for external CRO partners when needed May provide matrix or line-function leadership for project teams when needed undefined

Computer Skills: Proficiency with mass spectrometry data acquisition, processing, and analysis software Strong computational and data analysis skills, including experience analyzing complex quantitative mass spectrometry datasets Experience with software and tools for MS-based screening and assay development

Required Qualifications

• Ph.D., M.S., or B.S. degree in Analytical Chemistry, Biochemistry, Biology, Chemistry, Pharmaceutical Sciences, or a related scientific discipline, and 2+ years (Ph.D.), 4+ years (M.S.), or 5+ years (B.S.) of relevant industry, academic, or postdoctoral experience. Ph.D. strongly preferred.
• Strong foundation in mass spectrometry, with hands‑on experience operating, troubleshooting, and optimizing LC-MS instrumentation.
• Experience developing and implementing mass spectrometry-based analytical, screening, and/or proteomics workflows.
• Demonstrated ability to apply mass spectrometry approaches to address biological questions and support drug discovery research.
• Experience with quantitative proteomics and/or other MS-based approaches for protein identification, characterization, interaction analysis, or pathway interrogation.
• Experience developing and optimizing sample preparation, chromatography, and mass spectrometry methods for biological applications.
• Strong data analysis and interpretation skills, with the ability to derive meaningful conclusions from complex mass spectrometry datasets.
• Ability to troubleshoot analytical challenges and contribute creative solutions to technical and scientific problems.
• Ability to collaborate effectively with scientists across biology, chemistry, and related disciplines to develop fit-for-purpose analytical approaches.
• Strong written, verbal, and presentation skills, with the ability to communicate scientific findings to multidisciplinary teams.
• Ability to work on-site in San Carlos, CA.

Preferred Qualifications

• Experience with Orbitrap systems (Astral a plus) and/or Agilent Q-TOFs Knowledge of cancer pathways.
• Experience with ASMS and APMS workflows (in a drug discovery setting a plus)

Travel

None

Global Competencies

When we exhibit our values of Patients First, Driving Excellence, Bold Ingenuity and Collaborative Spirit, through our twelve global competencies below, we help get more affordable medicines to more patients around the world.

• Fosters Teamwork
• Provides and Solicits Honest and Actionable Feedback
• Self‑Awareness
• Acts Inclusively
• Demonstrates Initiative
• Entrepreneurial Mindset
• Continuous Learning
• Embraces Change
• Results‑Oriented Analytical Thinking/Data Analysis
• Financial Excellence
• Communicates with Clarity

Salary Range

$150,200.00 - $187,800.00 annually

Benefits

• Medical
• Dental
• Vision
• 401(k)
• FSA/HSA
• Life Insurance
• Paid Time Off
• Wellness

Non-Commercial roles are eligible to participate in the annual bonus plan, and Commercial roles are eligible to participate in an incentive compensation plan.

All Company employees have the opportunity to own shares of BeOne Medicines Ltd. stock because all employees are eligible for discretionary equity awards and to voluntarily participate in the Employee Stock Purchase Plan.

We are proud to be an equal opportunity employer. BeOne does not discriminate on the basis of race, religion, color, sex, gender identity, sexual orientation, age, disability, national origin, veteran status or any other basis covered by appropriate law. All employment is decided on the basis of qualifications, merit, and business need.

In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Assistance Act of 1974, Title I of the Americans with Disabilities Act of 1990, and any other applicable federal, state or local laws, applicants who require reasonable accommodation in the job application process may contact [e-mail].

BeOne is a global oncology company that is discovering and developing innovative treatments that are more affordable and accessible to cancer patients worldwide. With a broad portfolio, we are expediting development of our diverse pipeline of novel therapeutics through our internal capabilities and collaborations. We are committed to radically improving access to medicines for far more patients who need them.

Our growing global team of more than 11,000 colleagues spans six continents.

To learn more about BeOne, please visit www.beonemedicines.com and follow us on LinkedIn, X (formerly known as Twitter), Facebook and Instagram.

For more information, please visit the link to explore job opportunities in China Mainland.

China Mainland Job Posting At BeOne, how we work is just as important as the work we do. Below are our Values that determine the decisions we make and how we do things. Patients First Driving Excellence Bold Ingenuity Collaborative Spirit