Senior Scientist in Protein Engineering and TCE Development

Shennon Biotechnologies; San Francisco (CA); On-site; USD 120,000 - 160,000; Full time

Benefits offered by this job

Medical, Dental, Vision; 100% Premium

Daily lunches

Commuter benefits

Equity

401k match

Disability Insurance

Life Insurance

Job summary

Shennon Biotechnologies is seeking a TCE development scientist to join our interdisciplinary team in San Francisco. You will design TCEs, optimize development campaigns, and work with antibody discovery, production, and biophysical characterization to advance therapeutic candidates.

The role requires a PhD in Biochemistry or related field with 2+ years of industry experience, strong collaboration, and excellent communication.

Qualifications

• PhD in Biochemistry, Protein engineering, Bioengineering, or related field.
• 2+ years of industry experience leading the design, production and developability optimization of TCEs or multispecific antibodies.
• Excellent communication and collaboration skills.

Responsibilities

• Design TCEs and execute development and optimization campaigns.
• Collaborate on antibody discovery, TCE production and characterization.
• Drive developability assessment and biophysical characterization.
• Manage external relationships and deliverables.
• Collaborate with computational scientists and immunologists to optimize candidates through engineering and in vitro/in vivo studies.

Skills

Biochemistry

Protein engineering

Molecular biology

Communication

Collaboration

Education

PhD in Biochemistry / related field

Tools

AKTA system

Phage display

Yeast display

Job description

We are a well-funded biotech company that is redefining biologics discovery and development through our fully integrated platform. We combine ultra-high-throughput microfluidics driven functional screening, computational engineering, and translational immunology into a unified engine. Rather than approaching biologics development as a series of disconnected steps, we seamlessly integrate the discovery of novel targets, functional screening of binders, computational optimization, and predictive safety assessment to develop more better and safer therapeutics. This end-to-end approach enables faster iteration, deeper biological insight, and the development of better TCEs with greater precision and confidence.

We are currently looking for a TCE development scientist to join our interdisciplinary team. The candidate is expected to adapt quickly and communicate well, especially in a fast-paced startup environment. They will collaborate with other team members and be part of an exciting journey. We pay competitive salaries with bonus and equity, plus full benefits that include medical, dental, vision, 401k match, commuter benefits and daily lunch.

Responsibilities

• Design TCEs and execute their development and optimization campaigns.
• Work with internal and external teams on antibody discovery, TCE production and characterization.
• Drive TCE developability assessment and biophysical characterization.
• Manage external relationships and deliverables.
• Collaborate cross-functionally with computational scientists and immunologists to optimize and validate candidate molecules through iterative engineering and in vitro/in vivo studies.

Skills and Qualifications

• PhD degree in Biochemistry, Protein engineering, Bioengineering, or a related field.
• Strong background in Biochemistry, Protein engineering, and Molecular biology.
• 2+ years of industry experience leading the design, production, and developability optimization of TCEs or multi-specific antibodies.
• Experience with library construction/screening using phage/yeast display is a plus.
• Experience with antibody purification using AKTA system is a plus.
• Experience working with CROs is plus.
• Ability to work in a fast-paced startup environment, take initiative, and drive projects forward independently.
• Excellent communication and collaboration skills.

Compensation and Benefits

Compensation

• $120,000 - $160,000 (depending on the depth of expertise) + 4% 401K match + 10% performance bonus + equity.
• We will also consider a Principal Scientist with proven technical expertise plus cross-functional project leadership. Compensation will be adjusted accordingly.

Benefits

• Daily lunches; Commuter Benefits; Unlimited snacks and drinks.
• Medical, Dental, Vision; 100% Premium Covered.
• Disability Insurance, Life Insurance; Workplace Insurance