Senior Scientist II, Process Chemistry

Revolution Medicines, Inc.; San Francisco (CA); On-site; USD 170,000 - 212,000; Full time

Job summary

Revolution Medicines is seeking an advanced career scientist to lead hands‑on process chemistry work critical to our RAS‑ON program. You will design pivotal experiments, guide cross‑disciplinary teams, and drive scale‑up and technology transfer to CDMOs.

The role supports regulatory filings and requires strong technical judgment in complex development contexts. The position bases onsite at our Redwood City headquarters with a focus on delivering robust, scalable drug substance processes.

Qualifications

• PhD in organic chemistry with 8+ years in pharmaceutical process development.
• Solving complex small‑molecule process chemistry problems and delivering robust clinical manufacturing processes.
• Contributing to regulatory submissions and leading process development, scale‑up, and tech transfer.
• Leadership of cross‑disciplinary scientific teams with staff supervision.

Responsibilities

• Design and execute pivotal experiments to resolve chemistry problems and test hypotheses.
• Lead investigations of reaction behavior, process variability, and impurity formation with justified conclusions.
• Direct integrated process development across programs, setting priorities and evaluating strategies.
• Manage scientists and research associates, with coaching and performance feedback.
• Lead cross‑disciplinary discussions with analytics, quality, manufacturing, regulatory, and supply chain.
• Oversee lab scale‑up and technology transfer to CDMOs, assessing risks and resolving manufacturing issues.
• Author and review process chemistry docs to support regulatory filings with robust development evidence.
• Identify implications of findings for future development and maintain safety and knowledge capture.

Skills

PhD in Organic Chemistry

Advanced synthesis

Experimental design

Regulatory submissions experience

Leadership of scientific teams

Education

PhD in Organic Chemistry

Job description

Revolution Medicines is a global, commercial-state oncology company dedicated to discovering, developing and delivering innovative medicines for patients with RAS-addicted cancers. Leveraging its differentiated RAS(ON) tri-complex inhibitor platform, the company is advancing a broad, integrated portfolio of oral RAS(ON) inhibitors designed to directly target the active, cancer-driving state of RAS. Founded on rigorous scientific inquiry and a willingness to challenge long-held assumptions, Revolution Medicines is committed to changing the trajectory of disease for patients with RAS-addicted cancers worldwide.

Our people are united by a shared way of working: follow the science, challenge assumptions, act with urgency and hold ourselves to a high standard of rigor—all in service of patients.

The Opportunity:

We are seeking an advanced career scientist with a passion for process chemistry. You will be a hands‑on experimentalist leading scientific investigations, coordinating cross‑disciplinary decisions, and solving critical problems affecting process transfer and clinical supply. You will own complex drug substance development work. The role requires experience working in support of regulatory filings, and a record of solving problems, and exercising sound technical judgment in complex and ambiguous development situations.

• Personally design and execute pivotal experiments to resolve difficult chemistry problems, develop new methods, and test high‑impact scientific hypotheses.
• Lead investigations of complex reaction behavior, process variability, and impurity formation; establish scientifically justified recommendations for process control.
• Direct integrated process development across assigned programs or complex workstreams, establishing technical priorities and evaluating alternative development strategies.
• Manage a small group of scientists and research associates, developing technical capability through clear objectives, rigorous data review, coaching, and performance feedback.
• Lead cross‑disciplinary technical discussions and decisions with analytical development, quality, manufacturing, regulatory, and supply chain partners.
• Direct laboratory scale‑up and technology transfer to CDMOs, evaluate implementation risks, and lead resolution of significant manufacturing problems.
• Author and review process chemistry documentation and scientific justifications in support of regulatory filings, ensuring that development evidence supports the proposed manufacturing process.
• Identify broader implications of experimental findings for subsequent development, influence project strategy, and maintain strong standards of laboratory safety and knowledge capture.

Required Skills, Experience and Education:

• PhD in organic chemistry and at least 8 years of related experience, which may include postdoctoral research, with substantial pharmaceutical industry process development experience.
• A record of solving complex and ambiguous small‑molecule process chemistry problems and delivering robust processes for clinical manufacturing.
• Direct experience contributing to regulatory submissions and leading process development, scale‑up, and technology transfer activities.
• Advanced hands‑on synthesis, experimental design, mechanistic reasoning, impurity investigation, and interpretation of analytical evidence.
• Demonstrated leadership of cross‑disciplinary scientific work and experience supervising scientific staff and developing direct reports.
• Strong understanding of cGMP manufacturing, drug substance control strategies, process safety, and development needs from early through later stages.
• Ability to make and communicate consequential technical recommendations, balance competing project needs, and remain active in the laboratory.

Preferred Skills:

• Experience supporting multiple IND submissions or progressing drug substance processes through successive clinical development stages.
• Experience developing novel process solutions, leading significant manufacturing investigations, or contributing to scientific publications or intellectual property.

The base pay salary range for this full‑time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job‑related skills, experience, market dynamics, and relevant education or training.

Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact [e-mail].

Base Pay Salary Range

$170,000 - $212,000 USD